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Scientific Research on Fennel Essential Oil
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Fennel (Foeniculum vulgare of the family Apiaceae) is an aromatic seed used as spice and flavorant. This species is divided into two common market sources of Fennel, 'sweet fennel' (Foeniculum vulgare Mill. subsp. vulgare var. vulgare) and 'bitter fennel' (Foeniculum vulgare Mill. subsp. vulgare var. dulce). They are also sometimes used merely between meals to freshen the breath, and may also be used with meals for supposed carminative (flatulence reducing) purposes.
Most usage of Fennel is for culinary purposes and as aromatic
Medicinally, Fennel has been used in Europe and some Mediterranean areas for the purposes of antispasmodic, diuretic, anti-inflammatory, analgesic, secretomotor, secretolytic, galactagogue and emmenagogue, eye lotion, and antioxidant remedy and integrator. In Iranian medicine Fennel goes by the names Razianeh, Razianaj, Badiyan, and Marsoun and is said to have a 'hot and dry' nature (according to Iranian medicine).
The aromatic essential oil of Fennel tends to contain:
Estragole (aka. Methyl chavicol at 2.2-2.5%)
α-pinene (3.8%) and β-pinene (0.7%)
Usually, essential oil for marketing purposes is standardized for at least 80% Anethole with less than 10% Estragole and no more than 7.5% Fenchone.
The essential oil is very high in Anethole and Fenchone, which are likely the two main bioactives when using Fennel for Aromatherapy (due to their quantities)
The seeds of Fennel (more inclusive than just the essential oil) tend to contain:
Estragole can be metabolized via O-demethylation (to produce Chavicol) or 1-hydroxylation (to form 1'-hydroxyestragole) with increasing oral doses favoring 1-hydroxylation over O-demethylation.
1'-hydroxyestagole can be converted to 1′-sulfooxyestragole via sulfotransferases, which is an unstable intermediate thought to be involved with forming DNA adducts and possible carcinogenesis. Another pathway, the metabolism of 1'-hydroxyestragole via glucuronidation (to form 1'-hydroxyestragole glucuronide) is dose-dependent and accounts for as much as 24% and 33% of the estragole urinary metabolites in rats and mice, respectively, and has been detected in human liver cells (although fairly variable).
Estragole appears to be metabolized into either Chavicol or 1'-hydroxyestragole, with the latter following more routes of metabolism via P450 enzymes
Chewing of 1g of Fennel seeds for a minute, in a small (n=5) unblinded study, has been shown to increase salivary nitric oxide concentrations by just over two-fold (data derived from graph). 
Estragole, via its metabolite 1'-hydroxyestragole (and the metabolite 1-sulfooxyestragole) appears to have carcinogenic potential at oral intake of 0.23% and 0.46% (by weight) of the rat diet for one year (inducing hepatoma at 56% and 71% of the rats, respectively) although this study has been critiqued that even control appeared to bear hepatomas after a year.
Injections of 400mg/kg Estragole has been noted to cause 1 DNA adduct per 10.000–15.000 DNA nucleotides (CD-1 female mice)
An allergic reaction to Fennel is possible, and appears to be associated with Birch and Mugwort allergies (other plants in the Apiaceae family). Allergy to Fennel appears to also be related to Peach allergies (this study noting that out of 148 persons with peach allergies, the seemignly rare Fennel allergy was present in 39% of persons), which appears to be related to a 9kDa lipid-transfer protein present in Fennel having high cross-reactivity with known peach allergins.
An allergy to Fennel is possible. It is possible that, if you are allergic to peach or other plants in the same family as Fennel (Birch an Mugwort), that these may be used as indicators of possible Fennel allergy
- Gori L, et al. Can estragole in fennel seed decoctions really be considered a danger for human health? A fennel safety update. Evid Based Complement Alternat Med. (2012)
- Swaminathan A, et al. Nitrites derived from Foneiculum vulgare (fennel) seeds promotes vascular functions. J Food Sci. (2012)
- Rahimi R, Ardekani MR. Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy. Chin J Integr Med. (2013)
- Trellakis S, et al. Subconscious olfactory influences of stimulant and relaxant odors on immune function. Eur Arch Otorhinolaryngol. (2012)
- Tschiggerl C, Bucar F. Volatile fraction of lavender and bitter fennel infusion extracts. Nat Prod Commun. (2010)
- Zangouras A, et al. Dose dependent conversion of estragole in the rat and mouse to the carcinogenic metabolite, 1'-hydroxyestragole. Biochem Pharmacol. (1981)
- Alhusainy W, et al. Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect. Toxicol Appl Pharmacol. (2010)
- Iyer LV, et al. Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. Toxicol Sci. (2003)
- Miller EC, et al. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res. (1983)
- Randerath K, et al. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice. Carcinogenesis. (1984)
- Opinion of the Scientific Committee on Food on Estragole (1-Allyl-4-methoxybenzene).
- Smith RL, et al. Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem Toxicol. (2002)
- Perry R, Hunt K, Ernst E. Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics. (2011)
- Asero R. Fennel, cucumber, and melon allergy successfully treated with pollen-specific injection immunotherapy. Ann Allergy Asthma Immunol. (2000)
- Asero R. Relevance of pollen-specific IgE levels to the development of Apiaceae hypersensitivity in patients with birch pollen allergy. Allergy. (1997)
- Pastorello EA, et al. Fennel Allergy Is a Lipid-Transfer Protein (LTP)-Related Food Hypersensitivity Associated with Peach Allergy. J Agric Food Chem. (2013)