Evodia rutaecarpa

Last Updated: September 28 2022

Used in Traditional Chinese Medicine to increase warmth in the body. It might burn fat, but has not really been looked into it; might also decrease the perception of cold like capsaicin does, which indirectly warms you. A good berry for your oats in the winter.

Evodia rutaecarpa is most often used for

Summary

Evodia rutaecarpa is the plant which bears the berries evodia fructae (Fruits of Evodia), which are eaten in Traditional Chinese Medicine as a warming technique. The plant is also touted to reduce pain and gastrointestinal distress, and be anti-cancer.

It has been investigated as a fat burner, but no significantly promising evidence has been shown at this moment in time. It does appear to make animals feel hotter and quite reliably so, but this is a combination of increased heat expenditure (which is a fat burning effect) and minimizing the perception of cold via TRPV1 agonism, similar to the red pepper extract capsaicin. This combination may make one feel warmer despite not increasing caloric expenditure much.

Two studies have been conducted on animals showing anti-obesity effects, but these appear to not be related to the warmth effect of Evodia fruit and they do not necessarily mean it can be used to burn fat.

Beyond that, it shows promise as an anti-cancer agent through some relatively unique mechanisms and shows limited use as a supplement; taking the active ingredients (evodiamine, rutaecarpine) out of the fruit and into a supplemental capsule drastically reduces oral bioavailability. Isolated supplements may be quite worthless outside of the colon and stomach, with fruit or an ethanolic fruit extract being needed to reach the blood in appreciable amounts

What else is Evodia rutaecarpa known as?
Note that Evodia rutaecarpa is also known as:
  • Wuzhuyu
  • Wu Zhu Yu
  • Wu Zhu Yu Tang
  • Evodiae Fructus
  • Evodia Fruit
  • Evodia Fructae
Evodia rutaecarpa should not be confused with:
  • Evodiamine (bioactive)
  • Rutaecarpine (bioactive)
Dosage information

There are currently no human studies on evodia rutaecarpa berries.

Traditional usage of the berries involves making a decoction using 3-9g of the berries and then dividing said decoction into either two servings daily (morning and evening) or thrice daily (morning, noon, and evening)

References
2.^Ueng YF, Don MJ, Peng HC, Wang SY, Wang JJ, Chen CFEffects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymesJpn J Pharmacol.(2002 Jul)
3.^Ueng YF, Don MJ, Jan WC, Wang SY, Ho LK, Chen CFOxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450Drug Metab Dispos.(2006 May)
4.^Cai F, Wu J, Tian HY, Yuan XF, Jiang RWEvodiamideActa Crystallogr Sect E Struct Rep Online.(2012 Feb 1)
7.^Hu CQ, Li KK, Yang XWNew glycosidic alkaloid from the nearly ripe fruits of Euodia rutaecarpaJ Asian Nat Prod Res.(2012 May 15)
8.^Chuang WC, Cheng CM, Chang HC, Chen YP, Sheu SJContents of constituents in mature and immature fruits of evodia speciesPlanta Med.(1999 Aug)
9.^Lin LC, Li SH, Wu YT, Kuo KL, Tsai THPharmacokinetics and urine metabolite identification of dehydroevodiamine in the ratJ Agric Food Chem.(2012 Feb 22)
10.^Huang X, Li W, Yang XWNew cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpaFitoterapia.(2012 Jun)
11.^Zhao MY, Yang XWTwo new acylgluconic acids from the nearly ripe fruits of Evodia rutaecarpaJ Asian Nat Prod Res.(2008 Jul-Aug)
15.^Zhang YT, Zhao JH, Zhang SJ, Zhong YZ, Wang Z, Liu Y, Shi F, Feng NPEnhanced transdermal delivery of evodiamine and rutaecarpine using microemulsionInt J Nanomedicine.(2011)
18.^Ding JS, Gao R, Li D, Peng J, Ran LL, Li YJSolid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive ratsBiopharm Drug Dispos.(2008 Dec)
20.^Yan R, Wang Y, Shen W, Zhao X, Zhang XRelative Determination of Dehydroevodiamine in Rat Plasma by LC-MS and Study on its PharmacokineticsJ Chromatogr Sci.(2012 Aug)
22.^Ahn SH, Jeon SH, Tsuruo T, Shim CK, Chung SJPharmacokinetic characterization of dehydroevodiamine in the rat brainJ Pharm Sci.(2004 Feb)
25.^Jan WC, Lin LC, Don MJ, Chen CF, Tsai THElimination of rutaecarpine and its metabolites in rat feces and urine measured by liquid chromatographyBiomed Chromatogr.(2006 Nov)
26.^Ueng YF, Jan WC, Lin LC, Chen TL, Guengerich FP, Chen CFThe alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomesDrug Metab Dispos.(2002 Mar)
31.^Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya TCapsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonistPlanta Med.(2001 Oct)
32.^Callsen MG, Moller AT, Sorensen K, Jensen TS, Finnerup NBCold hyposensitivity after topical application of capsaicin in humansExp Brain Res.(2008 Dec)
34.^Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PMEvodiamine functions as an agonist for the vanilloid receptor TRPV1Org Biomol Chem.(2004 Aug 21)
35.^Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, Zhong J, Yan ZC, Wang LJ, Zhao ZG, Zhu SJ, Schrader M, Thilo F, Zhu ZM, Tepel MActivation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesityCirc Res.(2007 Apr 13)
39.^Choi YH, Shin EM, Kim YS, Cai XF, Lee JJ, Kim HPAnti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanismsArch Pharm Res.(2006 Apr)
40.^Liu YN, Pan SL, Liao CH, Huang DY, Guh JH, Peng CY, Chang YL, Teng CMEvodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7Shock.(2009 Sep)
42.^Moon TC, Murakami M, Kudo I, Son KH, Kim HP, Kang SS, Chang HWA new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpaInflamm Res.(1999 Dec)
44.^Chan AL, Chang WS, Chen LM, Lee CM, Chen CE, Lin CM, Hwang JLEvodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activityMolecules.(2009 Mar 27)
45.^Xu ML, Li G, Moon DC, Lee CS, Woo MH, Lee ES, Jahng Y, Chang HW, Lee SH, Son JKCytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalisArch Pharm Res.(2006 Jul)
49.^Zhu LH, Bi W, Liu XD, Li JF, Wu YY, Du BY, Tan YHInduction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippageOncol Rep.(2011 Dec)
51.^Zhang Y, Zhang QH, Wu LJ, Tashiro S, Onodera S, Ikejima TAtypical apoptosis in L929 cells induced by evodiamine isolated from Evodia rutaecarpaJ Asian Nat Prod Res.(2004 Mar)
53.^Chao DC, Lin LJ, Kao ST, Huang HC, Chang CS, Liang JA, Wu SL, Hsiang CY, Ho TYInhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cellsFitoterapia.(2011 Jun)
54.^Lee TJ, Kim EJ, Kim S, Jung EM, Park JW, Jeong SH, Park SE, Yoo YH, Kwon TKCaspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cellsMol Cancer Ther.(2006 Sep)
55.^Ogasawara M, Matsunaga T, Takahashi S, Saiki I, Suzuki HAnti-invasive and metastatic activities of evodiamineBiol Pharm Bull.(2002 Nov)
58.^Chen MC, Yu CH, Wang SW, Pu HF, Kan SF, Lin LC, Chi CW, Ho LL, Lee CH, Wang PSAnti-proliferative effects of evodiamine on human thyroid cancer cell line AROJ Cell Biochem.(2010 Aug 15)
59.^Wang C, Wang MW, Tashiro S, Onodera S, Ikejima TEffect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamineYao Xue Xue Bao.(2005 Nov)
61.^Zhang Y, Wu LJ, Tashiro S, Onodera S, Ikejima TEvodiamine induces tumor cell death through different pathways: apoptosis and necrosisActa Pharmacol Sin.(2004 Jan)
62.^Fei XF, Wang BX, Li TJ, Tashiro S, Minami M, Xing DJ, Ikejima TEvodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cellsCancer Sci.(2003 Jan)
64.^Wang XN, Zhou Q, Han X, Xu LN, Peng JYAnti-cancer activity of Zuojinwan in vivo and influence to tumor markers in mice transplanted with sarcoma 180Zhongguo Zhong Yao Za Zhi.(2008 Oct)
65.^Noh K, Seo YM, Lee SK, Bista SR, Kang MJ, Jahng Y, Kim E, Kang W, Jeong TCEffects of rutaecarpine on the metabolism and urinary excretion of caffeine in ratsArch Pharm Res.(2011 Jan)
68.^Lee SK, Kim NH, Lee J, Kim DH, Lee ES, Choi HG, Chang HW, Jahng Y, Jeong TCInduction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450sPlanta Med.(2004 Aug)
69.^Yang HB, Zhao YL, Li BC, Wang JB, Li RS, Jia L, Cheng DH, Xiao XHCOLD or HOT natural attribute of Zuojinwan and Fanzuojinwan based on temperature tropism of miceYao Xue Xue Bao.(2010 Jun)
70.^Ren YS, Wang JB, Zhao YL, Zhang P, Zhao HP, Zhang XR, Zhou CP, Xiao XH, Jin CCOLD and HOT nature of Coptis & Evodia and their prescriptions investigated with diet restriction/cold-water swimming mice modelsYao Xue Xue Bao.(2009 Nov)
74.^Ma BL, Yao MK, Han XH, Ma YM, Wu JS, Wang CHInfluences of Fructus evodiae pretreatment on the pharmacokinetics of Rhizoma coptidis alkaloidsJ Ethnopharmacol.(2011 Oct 11)
75.^Yang ZY, Pei J, Liu RM, Cheng J, Wan D, Hu RStudy on enhancing bioavailability of paeoniflorin by combined use with Chinese herbs for inner-warmingZhongguo Zhong Xi Yi Jie He Za Zhi.(2005 Sep)