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Diindolylmethane

Diindoylmethane (DIM) is a molecule which is named after its structure, two indole groups attached to a methane group. It is commonly found in broccoli, and holds promise as being a molecule for anti-cancer effects and as an aromatase inhibitor.

Our evidence-based analysis on diindolylmethane features 45 unique references to scientific papers.

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Summary of Diindolylmethane

Primary Information, Benefits, Effects, and Important Facts

Diindoylymethane (DIM) is a component of Indole-3-carbinol (I3C) found in members of the Brassica family. Most notably broccoli, kale, and cauliflower.

It has potent effects on estrogen metabolism and is able to keep the body relatively balanced (by preventing either drastic increases or decreases in estrogen). In small amounts, it can both inhibit the aromatase enzyme (and prevent conversion of testosterone into estrogen) and it can act on more potent forms of estrogen and convert them into less potent forms; this conversion reduces the overall effects of estrogen in the body. However, taking too much DIM at once can actually induce the aromatase enzyme and act in the opposite manner and increase estrogen synthesis.

DIM also exerts numerous anti-carcinogenic (anti-cancer) effects in the body and is one of the reasons this vegetable family is seen as healthy.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

A supplemental dose of approximately 100mg DIM has been noted to alter urinary estrogens in a manner thought to reflect less estrogenicity.

Things to Note

Also Known As

DIM, 3, 3'-diindolylmethane

Do Not Confuse With

Indole-3-Carbinol (it's precursor), Sulforaphane (another Broccoli Bioactive)

Goes Well With

  • Phenyl Isothiocyanate

Diindolylmethane is non-stimulatory

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Click here to see all 45 references.