Summary of Centrophenoxine
Primary Information, Benefits, Effects, and Important Facts
Centrophenoxine is a cholinergic compound with a DMAE (Dimethylaminoethanol) component, and acts as a better absorbed transporter of DMAE into the brain. It is sold under the brand name Lucidril but can easily be bought over the counter or online.
It is effective in reversing some of the signs of aging (particularly waste product buildup in the brain) when taken for an acute period (high doses for a month) and can act as a general neural enhancer and protector when taken continuously at a lower dose.
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Things To Know & Note
Centrophenoxine, via increasing acetylcholine levels, is stimulatory.
How to Take Centrophenoxine
Recommended dosage, active amounts, other details
For therapeutic usage in reducing lipofuscin (for the aged) 3-6 doses of 250mg centrophenoxine is generally touted.
For younger individuals seeking neurological enhancement and neuronal protection, 1-3 doses of 250mg suffices.
Research Breakdown on Centrophenoxine
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Centrophenoxine is able to reverse lipofuscin/beta-amyloid pigmentation build-up as well as act as an anti-oxidant against lipid peroxidation. Centrophenoxine can also increase RNA synthesis, protein synthesis, and glucose uptake in neurons and glial (support) cells. These latter effects are, however, dependent on the reductions of lipofuscin build-up and don't appear to affect youth with no lipofuscin build-up.
Centrophenoxine has been shown to be efficacious in treating dementia by increasing intracellular water content (of which dehydration is consistent with aging) and by increasing skills on cognition testing after 8 weeks of a 2g dose.
- Sharma D, Maurya AK, Singh R. Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine. Neurobiol Aging. (1993)
- Ludwig-Festl M, Gräter B, Bayreuther K. Increase in cell metabolism in normal, diploid human glial cells in stationary cell cultures induced by meclofenoxate. Arzneimittelforschung. (1983)
- Watanabe S, et al. Effects of various cerebral metabolic activators on glucose metabolism of brain. Folia Psychiatr Neurol Jpn. (1975)
- Fülöp T Jr, et al. Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial. Arch Gerontol Geriatr. (1990)