Cat's whiskers

Last Updated: September 28 2022

Orthosiphon stamineus (Java or Cat's Whiskers) is a plant whose leaves make a health tea, used mostly for its antiinflammatory and urinary health properties. It appears to be a large source of both rosmarinic acid and methylated flavonoids.

Cat's whiskers is most often used for

Summary

Orthosiphon stamineus (Java tea) is a leaf that is commonly brewed as a tea for a variety of purposes, but said purposes (beyond just liking the taste of the tea) tend to revolve around treating inflammatory disorders or treating ailments of the urogenital tract. It originates from the oceanic region and was introduced to mainland Asian countries and the West sometime near the beginning of the 20th century.

It is currently in preliminary stages of research and a lot of research is a bit complicated since it all originates from one research group located in Malaysia and needs to be replicated independently of the country from which it originated from (potentially a problem for scientific validity, since some studies investigating local herbs tend to be over promising in their effects and this excessive promise is attenuated a bit when other research groups look at it).

Nevertheless, there appears to be promise for this herb as a fat burner since the 70% ethanolic extract has been noted in two studies to stimulate leptin production in fat cells and increase in leptin have been noted in serum following oral ingestion of the leaf; reductions in food intake have been noted at only higher levels of intake, but are still thought to be associated with leptin.

While there is potential for this leaf as an antiinflammatory agent and diuretic, it has no practical research for the former that shows promise and while the evidence for the latter is a bit promising in rodents (does not exceed reference drugs in potency) the lone human study on the topic failed. There is one very promising study on colon cancer which definitely needs to be replicated by another research group, since reasonable oral intakes of the leaves potently suppressed colon tumor growth in mice.

All in all, pending future research this can be a potential new non-stimulatory fat burner for lean persons especially; we need quite a bit more evidence to confirm this though.

What else is Cat's whiskers known as?
Note that Cat's whiskers is also known as:
  • Java
  • Misai Kucing
  • Kumis Kucing
  • Cats Whiskers
  • Rau Meo
  • Cay Bac
  • Remujung
  • Moustaches De Chat
  • Yaa Nuat Maeo
  • Orthosiphon Stamineus
Cat's whiskers should not be confused with:
  • Java (Coffee nor the location it came from)
Dosage information

There is not enough information to get an ideal dose, but at this moment it seems that a 70% ethanolic extract would be the most prudent supplemental dosage for the production of leptin in the body. Since this has been noted in a highly variable range (as low as 20mg/kg in mice, as high as 450mg/kg in rats) it is uncertain what the best oral dose to take would be. Nonetheless, human equivalents for the above range are:

  • 110-4,900 mg for a 150lb person
  • 150-6,500 mg for a 200lb person
  • 180-8,100 mg for a 250lb person

The diuretic effect has been noted with tea, and thus brewing a tea from the leaves may be sufficient.

Examine Database
References
1.^Ameer OZ, Salman IM, Asmawi MZ, Ibraheem ZO, Yam MFOrthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicologyJ Med Food.(2012 Aug)
2.^Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CEIn vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19)J Ethnopharmacol.(2011 Jan 27)
4.^Mohamed EA, Siddiqui MJ, Ang LF, Sadikun A, Chan SH, Tan SC, Asmawi MZ, Yam MFPotent α-glucosidase and α-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from Orthosiphon stamineus Benth as anti-diabetic mechanismBMC Complement Altern Med.(2012 Oct 8)
5.^Tezuka Y, Stampoulis P, Banskota AH, Awale S, Tran KQ, Saiki I, Kadota SConstituents of the Vietnamese medicinal plant Orthosiphon stamineusChem Pharm Bull (Tokyo).(2000 Nov)
9.^Olah NK, Radu L, Mogoşan C, Hanganu D, Gocan SPhytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extractsJ Pharm Biomed Anal.(2003 Sep 15)
11.^Awale S, Tezuka Y, Banskota AH, Kouda K, Tun KM, Kadota SFive novel highly oxygenated diterpenes of Orthosiphon stamineus from MyanmarJ Nat Prod.(2001 May)
12.^Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota SHighly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activityChem Pharm Bull (Tokyo).(2003 Mar)
13.^Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota SNitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of IndonesiaJ Nat Prod.(2003 Feb)
15.^Kato-Noguchi H, Hamada N, Morita M, Suenaga KA novel allelopathic substance, 13-epi-orthosiphol N, in Orthosiphon stamineusJ Plant Physiol.(2013 Jan 1)
16.^Awale S, Tezuka Y, Banskota AH, Kadota SSiphonols A-E: novel nitric oxide inhibitors from Orthosiphon stamineus of IndonesiaBioorg Med Chem Lett.(2003 Jan 6)
18.^Sumaryono W, Proksch P, Wray V, Witte L, Hartmann TQualitative and Quantitative Analysis of the Phenolic Constituents from Orthosiphon aristatusPlanta Med.(1991 Apr)
22.^Abdelwahab SI, Mohan S, Mohamed Elhassan M, Al-Mekhlafi N, Mariod AA, Abdul AB, Abdulla MA, Alkharfy KMAntiapoptotic and Antioxidant Properties of Orthosiphon stamineus Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic PathwayEvid Based Complement Alternat Med.(2011)
23.^Alshawsh MA, Abdulla MA, Ismail S, Amin ZA, Qader SW, Hadi HA, Harmal NSFree radical scavenging, antimicrobial and immunomodulatory activities of Orthosiphon stamineusMolecules.(2012 May 8)
24.^Yam MF, Mohamed EA, Ang LF, Pei L, Darwis Y, Mahmud R, Asmawi MZ, Basir R, Ahmad MA simple isocratic HPLC method for the simultaneous determination of sinensetin, eupatorin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in Orthosiphon stamineus extractsJ Acupunct Meridian Stud.(2012 Aug)
25.^Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CEIn vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymesChem Biol Interact.(2011 Mar 15)
28.^Muhammad H, Gomes-Carneiro MR, Poça KS, De-Oliveira AC, Afzan A, Sulaiman SA, Ismail Z, Paumgartten FJEvaluation of the genotoxicity of Orthosiphon stamineus aqueous extractJ Ethnopharmacol.(2011 Jan 27)
30.^Yuliana ND, Khatib A, Link-Struensee AM, Ijzerman AP, Rungkat-Zakaria F, Choi YH, Verpoorte RAdenosine A1 receptor binding activity of methoxy flavonoids from Orthosiphon stamineusPlanta Med.(2009 Feb)
31.^Wilcox CS, Welch WJ, Schreiner GF, Belardinelli LNatriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonistJ Am Soc Nephrol.(1999 Apr)
33.^Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DGCentral nervous system control of food intakeNature.(2000 Apr 6)
35.^Yam MF, Ang LF, Basir R, Salman IM, Ameer OZ, Asmawi MZEvaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extractInflammopharmacology.(2009 Feb)
36.^Kurokawa M, Kumeda CA, Yamamura J, Kamiyama T, Shiraki KAntipyretic activity of cinnamyl derivatives and related compounds in influenza virus-infected miceEur J Pharmacol.(1998 May 1)
37.^Matsubara T, Bohgaki T, Watarai M, Suzuki H, Ohashi K, Shibuya HAntihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plantBiol Pharm Bull.(1999 Oct)
42.^Mohamed EA, Mohamed AJ, Asmawi MZ, Sadikun A, Ebrika OS, Yam MFAntihyperglycemic effect of orthosiphon stamineus benth leaves extract and its bioassay-guided fractionsMolecules.(2011 May 4)
47.^White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CDHF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanismsAm J Physiol Endocrinol Metab.(2009 Feb)
48.^Laavola M, Nieminen R, Yam MF, Sadikun A, Asmawi MZ, Basir R, Welling J, Vapaatalo H, Korhonen R, Moilanen EFlavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activationPlanta Med.(2012 May)
49.^Yam MF, Ang LF, Salman IM, Ameer OZ, Lim V, Ong LM, Ahmad M, Asmawil MZ, Basir ROrthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in ratsJ Med Food.(2009 Oct)
51.^Alshawsh MA, Abdulla MA, Ismail S, Amin ZAHepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in RatsEvid Based Complement Alternat Med.(2011)
52.^Arafat OM, Tham SY, Sadikun A, Zhari I, Haughton PJ, Asmawi MZStudies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in ratsJ Ethnopharmacol.(2008 Aug 13)
53.^Adam Y, Somchit MN, Sulaiman MR, Nasaruddin AA, Zuraini A, Bustamam AA, Zakaria ZADiuretic properties of Orthosiphon stamineus BenthJ Ethnopharmacol.(2009 Jul 6)
54.^Doan DD, Nguyen NH, Doan HK, Nguyen TL, Phan TS, van Dau N, Grabe M, Johansson R, Lindgren G, Stjernström NEStudies on the individual and combined diuretic effects of four Vietnamese traditional herbal remedies (Zea mays, Imperata cylindrica, Plantago major and Orthosiphon stamineus)J Ethnopharmacol.(1992 Jun)
55.^Dolečková I, Rárová L, Grúz J, Vondrusová M, Strnad M, Kryštof VAntiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leavesFitoterapia.(2012 Sep)
57.^Vogelgesang B, Abdul-Malak N, Reymermier C, Altobelli C, Saget JOn the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfectionsInt J Cosmet Sci.(2011 Feb)
60.^Mohamed EA, Lim CP, Ebrika OS, Asmawi MZ, Sadikun A, Yam MFToxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineusJ Ethnopharmacol.(2011 Jan 27)