Butea monosperma

Last Updated: September 28 2022

Butea monosperma is a herb that contains a variety of methoxylated isoflavones, and some of these isoflavones (cajanin) and other bioactives such as medicarpin can preserve bone mass with a potency similar or greater than estrogen itself, although some are nonestrogenic.

Butea monosperma is most often used for

Summary

Butea monosperma is a traditional Indian medicinal tree that also serves as an ornamental tree due to its vibrant red flowers that it bears, resulting in the common name of 'Flame of the Forest'. It appears to mostly be recommended as a general health tonic and for the treatment of liver disorders.

The potential uses for this plant seem wholly different from its traditional uses, as it has shown some potential antidiabetic effects in rats (which need to be further investigated since we have no clue how they exert their benefits at this moment in time) but is most promising for the treatment of osteoporosis. A few flavonoids in this plant (Cajanin and Cladrin in particular) and one other molecule (Medicarpin) are structureally similar to isoflavones, and appear to be very potent at promoting bone health. Studies using these molecules in vitro have noted their effective doses compare with that of estrogen itself and they are just as potent (if not nonsignificantly more potent) at promoting bone growth; despite the potency, medicarpin is only slightly estrogenic and both Cajanin and Cladrin appear to be nonestrogenic.

Cajanin, Cladrin, Medicarpin, and one other flavonoid known as Isoformononetin all appear to be highly active in rats following an oral dose of 10mg/kg (human equivalent of 1.6mg/kg), and have been noted to fully prevent bone losses assocaited with menopause with daily ingestion. Despite the potency observed, however, human studies have not yet been conducted.

What else is Butea monosperma known as?
Note that Butea monosperma is also known as:
  • Butea frondosa
  • Erythrina monosperma
  • Plaso monosperma
  • The Treasurer of the Gods and of Sacrifice
  • kimsuk
  • muriku
  • moduga
  • Bastard Teak
  • Dhak
  • Palash
  • Flame of the Forest
  • Palăśa
Butea monosperma should not be confused with:
Dosage information

There is currently not enough evidence to suggest a recommended dose of this plant.

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References
2.^Prasad PV, Subhaktha PK, Narayana A, Rao MMPalăśa (Butea monosperma (Lamk.) Taub.) and its medico-historical studyBull Indian Inst Hist Med Hyderabad.(2006 Jul-Dec)
3.^Mathan G, Fatima G, Saxena AK, Chandan BK, Jaggi BS, Gupta BD, Qazi GN, Balasundaram C, Anand Rajan KD, Kumar VL, Kumar VChemoprevention with aqueous extract of Butea monosperma flowers results in normalization of nuclear morphometry and inhibition of a proliferation marker in liver tumorsPhytother Res.(2011 Mar)
5.^Shahavi VM, Desai SKAnti-inflammatory activity of Butea monosperma flowersFitoterapia.(2008 Feb)
6.^Kasture VS, Kasture SB, Chopde CTAnticonvulsive activity of Butea monosperma flowers in laboratory animalsPharmacol Biochem Behav.(2002 Jul)
7.^Prashanth D, Asha MK, Amit A, Padmaja RAnthelmintic activity of Butea monospermaFitoterapia.(2001 May)
8.^Iqbal Z, Lateef M, Jabbar A, Ghayur MN, Gilani AHIn vivo anthelmintic activity of Butea monosperma against Trichostrongylid nematodes in sheepFitoterapia.(2006 Feb)
9.^Thiagarajan VR, Shanmugam P, Krishnan UM, Muthuraman A, Singh NAmeliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in ratsAn Acad Bras Cienc.(2012 Dec)
10.^Sumitra M, Manikandan P, Suguna LEfficacy of Butea monosperma on dermal wound healing in ratsInt J Biochem Cell Biol.(2005 Mar)
13.^Unny R, Chauhan AK, Joshi YC, Dobhal MP, Gupta RSA review on potentiality of medicinal plants as the source of new contraceptive principlesPhytomedicine.(2003 Mar)
15.^Maurya R, Yadav DK, Singh G, Bhargavan B, Narayana Murthy PS, Sahai M, Singh MMOsteogenic activity of constituents from Butea monospermaBioorg Med Chem Lett.(2009 Feb 1)
16.^Pandey R, Gautam AK, Bhargavan B, Trivedi R, Swarnkar G, Nagar GK, Yadav DK, Kumar M, Rawat P, Manickavasagam L, Kumar A, Maurya R, Goel A, Jain GK, Chattopadhyay N, Singh DTotal extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fractionMenopause.(2010 May-Jun)
17.^Bandara BM, Kumar NS, Samaranayake KMAn antifungal constituent from the stem bark of Butea monospermaJ Ethnopharmacol.(1989 Feb)
21.^Wagner H, Geyer B, Fiebig M, Kiso Y, Hikino HIsobutrin and butrin, the antihepatotoxic principles of Butea monosperma flowersPlanta Med.(1986 Apr)
22.^Chokchaisiri R, Suaisom C, Sriphota S, Chindaduang A, Chuprajob T, Suksamrarn ABioactive flavonoids of the flowers of Butea monospermaChem Pharm Bull (Tokyo).(2009 Apr)
23.^Yadava RN, Tiwari LNew antifungal flavone glycoside from Butea monosperma O. KuntzeJ Enzyme Inhib Med Chem.(2007 Aug)
24.^Mishra M, Shukla YN, Kumar SEuphane triterpenoid and lipid constituents from Butea monospermaPhytochemistry.(2000 Aug)
25.^Srivastava M, Banerji R, Rawat AK, Mehrotra SFatty acid composition of some medicinally useful seedsJ Herb Pharmacother.(2006)
29.^Agarwal AK, Tripathi DM, Sahai R, Gupta N, Saxena RP, Puri A, Singh M, Misra RN, Dubey CB, Saxena KCManagement of giardiasis by a herbal drug 'Pippali Rasayana': a clinical studyJ Ethnopharmacol.(1997 May)
30.^Gautam AK, Bhargavan B, Tyagi AM, Srivastava K, Yadav DK, Kumar M, Singh A, Mishra JS, Singh AB, Sanyal S, Maurya R, Manickavasagam L, Singh SP, Wahajuddin W, Jain GK, Chattopadhyay N, Singh DDifferential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in ratsJ Nutr Biochem.(2011 Apr)
31.^Dixit P, Prakash T, Karki R, Kotresha DAnti-obese activity of Butea monosperma (Lam) bark extract in experimentally induced obese ratsIndian J Exp Biol.(2012 Jul)
33.^Thiagarajan VR, Shanmugam P, Krishnan UM, Muthuraman A, Singh NAntinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in ratsToxicol Ind Health.(2013 Feb)
34.^Somani R, Kasture S, Singhai AKAntidiabetic potential of Butea monosperma in ratsFitoterapia.(2006 Feb)
40.^Khan K, Sharan K, Swarnkar G, Chakravarti B, Mittal M, Barbhuyan TK, China SP, Khan MP, Nagar GK, Yadav D, Dixit P, Maurya R, Chattopadhyay NPositive skeletal effects of cladrin, a naturally occurring dimethoxydaidzein, in osteopenic rats that were maintained after treatment discontinuationOsteoporos Int.(2013 Apr)
41.^Bhargavan B, Gautam AK, Singh D, Kumar A, Chaurasia S, Tyagi AM, Yadav DK, Mishra JS, Singh AB, Sanyal S, Goel A, Maurya R, Chattopadhyay NMethoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signalingJ Cell Biochem.(2009 Oct 1)
42.^Tyagi AM, Gautam AK, Kumar A, Srivastava K, Bhargavan B, Trivedi R, Saravanan S, Yadav DK, Singh N, Pollet C, Brazier M, Mentaverri R, Maurya R, Chattopadhyay N, Goel A, Singh DMedicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized miceMol Cell Endocrinol.(2010 Aug 30)
44.^Lavhale MS, Mishra SHEvaluation of free radical scavenging activity of Butea monosperma LamIndian J Exp Biol.(2007 Apr)
46.^Gupta A, Sheth NR, Pandey S, Yadav JS, Shah DR, Vyas B, Joshi SEvaluation of protective effect of Butea monosperma (lam.) Taub in experimental hepatotoxicity in ratsJ Pharmacol Pharmacother.(2012 Apr)
53.^Donga S, Shukla VJ, Ravishankar B, Ashok BK, Mishtry IUChronic toxicity study of Butea monosperma (Linn.) Kuntze seeds in albino ratsAyu.(2011 Jan)
56.^Abhilash J, Geethanandan K, Bharath SR, Sadasivan C, Haridas MCrystallization and preliminary X-ray diffraction analysis of a galactose-specific lectin from the seeds of Butea monospermaActa Crystallogr Sect F Struct Biol Cryst Commun.(2011 Apr 1)