Bladderwrack
•Last Updated: September 28 2022
Bladderwrack is a species of seaweed known as Fucus vesiculosus that serves as a foodstuff and a source of Fucoxanthin, it is though to increase the metabolism via the thyroid but that is due to fixing iodine deficiencies historically.
Bladderwrack is most often used for
Last Updated: September 28 2022
Bladderwrack (formal name Fucus Vesiculosis) is a brown seaweed which is a good source of iodine (the mineral needed for proper thyroid function) and of various L-fucose compounds.
Said L-fucose compounds can be seen as generally being anti-obesity, anti-inflammatory, anti-oxidant, and anti-carcinogenic. There are also some implications of them being anti-viral and anti-diabetic.
Benefits can be seen from ingesting brown seaweeds as foodstuffs, or by consuming the L-fucose compounds or the seaweed itself in supplemental form; although the latter should be taken alongside food.
Note that Bladderwrack is also known as:
- Fucus Vesiculosis
Although there is not a large amount of evidence currently, the evidence in humans has noted that 500mg of bladderwrack (basic extract of the seaweed, not concentrated) appears to be bioactive. This is a lower dose than the 4,000mg used in studies on Ascophyllum nodosum, and due to their similar composition the ideal range may be somewhere in between these two doses (or above 4,000mg).
What works and what doesn't?
Unlock the full potential of Examine
2.^Saha M, Rempt M, Grosser K, Pohnert G, Weinberger FSurface-associated fucoxanthin mediates settlement of bacterial epiphytes on the rockweed Fucus vesiculosusBiofouling.(2011 Apr)
3.^Kwak KW, Cho KS, Hahn OJ, Lee KH, Lee BY, Ko JJ, Chung KHBiological effects of fucoidan isolated from Fucus vesiculosus on thrombosis and vascular cellsKorean J Hematol.(2010 Mar)
4.^Parys S, Kehraus S, Krick A, Glombitza KW, Carmeli S, Klimo K, Gerhäuser C, König GMIn vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymesPhytochemistry.(2010 Feb)
5.^Wang T, Jónsdóttir R, Liu H, Gu L, Kristinsson HG, Raghavan S, Olafsdóttir GAntioxidant Capacities of Phlorotannins Extracted from the Brown Algae Fucus vesiculosusJ Agric Food Chem.(2012 Jun 5)
6.^Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer ASFucose-containing sulfated polysaccharides from brown seaweeds inhibit proliferation of melanoma cells and induce apoptosis by activation of caspase-3 in vitroMar Drugs.(2011 Dec)
7.^Holan ZR, Volesky BBiosorption of lead and nickel by biomass of marine algaeBiotechnol Bioeng.(1994 May)
8.^Ryan S, McLoughlin P, O'Donovan OA comprehensive study of metal distribution in three main classes of seaweedEnviron Pollut.(2012 Aug)
9.^Steevensz AJ, Mackinnon SL, Hankinson R, Craft C, Connan S, Stengel DB, Melanson JEProfiling phlorotannins in brown macroalgae by liquid chromatography-high resolution mass spectrometryPhytochem Anal.(2012 Sep)
11.^Duarte ME, Cardoso MA, Noseda MD, Cerezo ASStructural studies on fucoidans from the brown seaweed Sargassum stenophyllumCarbohydr Res.(2001 Jul 19)
12.^Chemical Characterization of Acetyl Fucoidan and Alginate from Commercially Cultured Cladosiphon okamuranus.()
14.^Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer ASFucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivoInt J Biol Macromol.(2011 Oct 1)
15.^Irhimeh MR, Fitton JH, Lowenthal RM, Kongtawelert PA quantitative method to detect fucoidan in human plasma using a novel antibodyMethods Find Exp Clin Pharmacol.(2005 Dec)
16.^Tokita Y, Nakajima K, Mochida H, Iha M, Nagamine TDevelopment of a fucoidan-specific antibody and measurement of fucoidan in serum and urine by sandwich ELISABiosci Biotechnol Biochem.(2010)
17.^Kim KJ, Lee OH, Lee BYFucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytesLife Sci.(2010 May 22)
18.^Kim MJ, Chang UJ, Lee JSInhibitory effects of Fucoidan in 3T3-L1 adipocyte differentiationMar Biotechnol (NY).(2009 Sep-Oct)
19.^Park MK, Jung U, Roh CFucoidan from marine brown algae inhibits lipid accumulationMar Drugs.(2011)
20.^Skibola CFThe effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case reportBMC Complement Altern Med.(2004 Aug 4)
21.^Shimizu H, Ross RK, Bernstein L, Pike MC, Henderson BESerum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in JapanBr J Cancer.(1990 Sep)
22.^Key TJ, Chen J, Wang DY, Pike MC, Boreham JSex hormones in women in rural China and in BritainBr J Cancer.(1990 Oct)
23.^Cassidy A, Bingham S, Setchell KDBiological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal womenAm J Clin Nutr.(1994 Sep)
24.^Lu LJ, Anderson KE, Grady JJ, Kohen F, Nagamani MDecreased ovarian hormones during a soya diet: implications for breast cancer preventionCancer Res.(2000 Aug 1)
26.^Cumashi A, Ushakova NA, Preobrazhenskaya ME, D'Incecco A, Piccoli A, Totani L, Tinari N, Morozevich GE, Berman AE, Bilan MI, Usov AI, Ustyuzhanina NE, Grachev AA, Sanderson CJ, Kelly M, Rabinovich GA, Iacobelli S, Nifantiev NE; Consorzio Interuniversitario Nazionale per la Bio-Oncologia, ItalyA comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweedsGlycobiology.(2007 May)
27.^Mourão PAUse of sulfated fucans as anticoagulant and antithrombotic agents: future perspectivesCurr Pharm Des.(2004)
28.^Dürig J, Bruhn T, Zurborn KH, Gutensohn K, Bruhn HD, Béress LAnticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitroThromb Res.(1997 Mar 15)
29.^Church FC, Meade JB, Treanor RE, Whinna HCAntithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombinJ Biol Chem.(1989 Feb 25)
30.^Nishino T, Nagumo TAnticoagulant and antithrombin activities of oversulfated fucansCarbohydr Res.(1992 May 22)
31.^Sato M, Oba T, Yamaguchi T, Nakano T, Kahara T, Funayama K, Kobayashi A, Nakano TAntihypertensive effects of hydrolysates of wakame (Undaria pinnatifida) and their angiotensin-I-converting enzyme inhibitory activityAnn Nutr Metab.(2002)
32.^Ara J, Sultana V, Qasim R, Ahmad VUHypolipidaemic activity of seaweed from Karachi coastPhytother Res.(2002 Aug)
33.^Neglia CI, Cohen HJ, Garber AR, Ellis PD, Thorpe SR, Baynes JW13C NMR investigation of nonenzymatic glucosylation of protein. Model studies using RNase AJ Biol Chem.(1983 Dec 10)
34.^Petersen DR, Doorn JAReactions of 4-hydroxynonenal with proteins and cellular targetsFree Radic Biol Med.(2004 Oct 1)
35.^Negre-Salvayre A, Coatrieux C, Ingueneau C, Salvayre RAdvanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitorsBr J Pharmacol.(2008 Jan)
36.^Ahmed NAdvanced glycation endproducts--role in pathology of diabetic complicationsDiabetes Res Clin Pract.(2005 Jan)
37.^Münch G, Thome J, Foley P, Schinzel R, Riederer PAdvanced glycation endproducts in ageing and Alzheimer's diseaseBrain Res Brain Res Rev.(1997 Feb)
38.^Liu H, Gu LPhlorotannins from brown algae (Fucus vesiculosus) inhibited the formation of advanced glycation endproducts by scavenging reactive carbonylsJ Agric Food Chem.(2012 Feb 8)
39.^Paradis ME, Couture P, Lamarche BA randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and womenAppl Physiol Nutr Metab.(2011 Dec)
40.^Cederholm J, Wibell LInsulin release and peripheral sensitivity at the oral glucose tolerance testDiabetes Res Clin Pract.(1990 Oct)
41.^Lamela M, Anca J, Villar R, Otero J, Calleja JMHypoglycemic activity of several seaweed extractsJ Ethnopharmacol.(1989 Nov)
42.^Maruyama H, Tamauchi H, Iizuka M, Nakano TThe role of NK cells in antitumor activity of dietary fucoidan from Undaria pinnatifida sporophylls (Mekabu)Planta Med.(2006 Dec)
43.^Wang J, Zhang Q, Zhang Z, Song H, Li PPotential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonicaInt J Biol Macromol.(2010 Jan 1)
44.^Ravi Kumar S, Narayan B, Vallikannan BFucoxanthin restrains oxidative stress induced by retinol deficiency through modulation of Na(+)K(+)-ATPase {corrected} and antioxidant enzyme activities in ratsEur J Nutr.(2008 Dec)
45.^Li C, Gao Y, Xing Y, Zhu H, Shen J, Tian JFucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia-reperfusion injury in rats via regulating the inflammation responseFood Chem Toxicol.(2011 Sep)
46.^Heo SJ, Yoon WJ, Kim KN, Ahn GN, Kang SM, Kang DH, Affan A, Oh C, Jung WK, Jeon YJEvaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophagesFood Chem Toxicol.(2010 Aug-Sep)
47.^Kim KN, Heo SJ, Yoon WJ, Kang SM, Ahn G, Yi TH, Jeon YJFucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophagesEur J Pharmacol.(2010 Dec 15)
48.^Morita K, Nakano TSeaweed accelerates the excretion of dioxin stored in ratsJ Agric Food Chem.(2002 Feb 13)
49.^Al-Bader T, Byrne A, Gillbro J, Mitarotonda A, Metois A, Vial F, Rawlings AV, Laloeuf AEffect of cosmetic ingredients as anticellulite agents: synergistic action of actives with in vitro and in vivo efficacyJ Cosmet Dermatol.(2012 Mar)
50.^Fujimura T, Tsukahara K, Moriwaki S, Kitahara T, Sano T, Takema YTreatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical propertiesJ Cosmet Sci.(2002 Jan-Feb)
51.^Fujimura T, Shibuya Y, Moriwaki S, Tsukahara K, Kitahara T, Sano T, Nishizawa Y, Takema YFucoidan is the active component of fucus vesiculosus that promotes contraction of fibroblast-populated collagen gelsBiol Pharm Bull.(2000 Oct)
52.^Chung HJ, Jeun J, Houng SJ, Jun HJ, Kweon DK, Lee SJToxicological evaluation of fucoidan from Undaria pinnatifidain vitro and in vivoPhytother Res.(2010 Jul)
53.^Kim KJ, Lee OH, Lee HH, Lee BYA 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley ratsToxicology.(2010 Jan 12)
54.^Zhuang C, Itoh H, Mizuno T, Ito HAntitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii)Biosci Biotechnol Biochem.(1995 Apr)
55.^Li N, Zhang Q, Song JToxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar ratsFood Chem Toxicol.(2005 Mar)
56.^Gideon TP, Rengasamy RToxicological evaluation of fucoidan from Cladosiphon okamuranusJ Med Food.(2008 Dec)