Quick Summary
In this meta-analysis of randomized controlled trials, supplementation with probiotics had no effect on clinical or biochemical outcomes in adults with dental implant diseases.
What was studied?
The effect of supplementation with probiotics on clinical and biochemical outcomes in the context of peri-implant mucositis (early inflammation around dental implants that primarily affects the gums) and peri-implantitis (advanced-stage inflammation that also affects the bone around dental implants).
The following outcomes were studied:
- Clinical outcomes: bleeding on probing, plaque severity, and probing depth
- Inflammatory biomarkers: interleukin 1-beta, interleukin 6, interleukin 8, and tumor necrosis factor-alpha
Who was studied?
A total of 340 adults with peri-implant mucositis and/or peri-implantitis.
How was it studied?
A meta-analysis of 10 randomized controlled trials was conducted. Probiotics were taken orally in 6 trials and applied topically in 4 trials. Single or multiple probiotic strains from the Lactobacillus genus were used in 9 trials, and 1 trial used probiotic strains from the Lactobacillus and Bifidobacterium genera. The comparator was a placebo in 9 trials and no intervention in 1 trial. The follow-up duration ranged from 4 to 26 weeks.
The researchers conducted 2 main meta-analyses, combining all outcomes for peri-implant mucositis and peri-implantitis, as well as subgroup analyses for each individual outcome.
What were the results?
Supplementation with probiotics had no effect on any of the individual or combined outcomes.
The risk of bias was low in 3 trials and unclear in 7 trials.
This Study Summary was published on June 18, 2024.