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Inflammation

Inflammation is the response of immune cells to tissue damage, pathogens, and other intrusions, with the purpose of healing and restoring cells. It's a vital process, but when it’s excessive or prolonged, it causes pain, damage tissues, and disrupt physiological functions, thereby leading to many health issues.

Our evidence-based analysis on inflammation features 3 unique references to scientific papers.

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Summary of Inflammation

Inflammation is the response of immune cells to tissue damage, pathogens, and other intrusions, with the purpose of healing and restoring cells. Acute inflammation entails a number of adaptations that take place to protect and repair the body. Immune cells are recruited to the site to combat any pathogens they encounter, while some cells secrete proteins that help to clear dead cells and damaged extracellular matrix, and facilitate healing. Pain, heat, and increased blood flow are also common features.

That’s the healthy, adaptive part of inflammation.Then there’s chronic inflammation, which is a persistent elevation of inflammation that affects many parts of the body continuously. It may be caused by a persist injury or an inability to clear an infection, but it’s also oftentimes caused by excess adipose tissue, metabolic stress and dysregulation, a compromised microbiome and gut barrier, persistent exposure to toxicants, and autoimmunity, where the immune system attacks the body directly. A lack of the nutrients, cells, and friendly microbiota that are involved in immune regulation will make it all the worse, and lead to greater inflammatory activity for longer.

The inflammatory response, much like a war, is costly and leads to collateral damage. Inflammatory signaling molecules, the chemical weapons of immune cells, and the cellular breakdown, can damage and dysregulate our own cells and contribute to a wide variety of common diseases and disorders.

This page is for inflammation in general, and will include study outcomes of a variety of markers of inflammation, but will largely be made up of c-reactive protein, and various cytokines, as these are the most common inflammatory markers that are tested for. For information on a specific inflammatory marker, it’s best to search for it by name, and not to rely on this page.

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix looks at human studies to tell you what supplements affect Inflammation.

Full details on all Inflammation supplements are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Minor Moderate See all 17 studies
Highly mixed and unreliable influences on circulating inflammatory cytokines (although, due to immunosuppression on cellular adhesion factors, the overall effect may still be antiinflammatory)
grade-b Notable Very High See all 6 studies
There appears to be a decrease in disease states or conditions characterized by inflammation associated with curcumin ingestion, does not appear to be too discriminatory in which inflammatory states it benefits
grade-b Minor Very High See all 4 studies
Inflammatory parameters seem to be reduced following ginger consumption

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Frequently Asked Questions and Articles on Inflammation

Should I take Fish Oil if I am sick?
Click here to see all 3 references.