Summary of Inflammation
Primary Information, Benefits, Effects, and Important Facts
Inflammation is the process of recruiting immune cells to tissues in the body for the purpose of destroying pathogens, toxic compounds, and facilitating healing after damage. Inflammed tissue is generally red and hot due to swelling with blood and increased heat production that facilitates the immune response. This is a beneficial and vital biological process, but when it's excessive or prolonged, it plays a role in a wide variety of of diseases of aging and disorders through damaging tissue or disrupting important biological functions.
Excessive inflammation plays a part in cardiovascular diseases, type 2 diabetes, neurodegenerative diseases, cancers, depression, and more. Oftentimes the influx of cytokines (signaling molecules that tell immune cells what to do) have broad roles, and interfere with the normal functioning of cells, originally for the purpose of combating the threat, but when inflammation is too common and too potent, cellular function is impaired too frequently, leading to broader issues (such as the suppression of glucose uptake by inflammatory cytokines, which plays a part in insulin resistance). Additionally, the collateral damage done by immune cells' chemical weapons, or through purposeful degradation of extracellular matrixes or aptopsis.
Foods and supplements that regulate or prevent excessive inflammation may do so through being regulators of immune cells, influencing the production of immune regulators, or preventing inflammatory stimuli in the first place,
This outcome contains a broad assessment of inflammation, oftentimes referring to multiple inflammatory markers. For specific information on particular inflammatory markers, refer to the entries for those, as they may be more accurate.
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect inflammation.
|Grade||Level of Evidence [show legend]|
|Robust research conducted with repeated double-blind clinical trials|
|Multiple studies where at least two are double-blind and placebo controlled|
|Single double-blind study or multiple cohort studies|
|Uncontrolled or observational studies only|
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|Minor||Moderate See all 17 studies|
|Notable||Very High See all 6 studies|
|Minor||Very High See all 4 studies|
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Frequently Asked Questions and Articles on Inflammation
Click here to see all 3 references.