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Heartburn

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Summary of Heartburn

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Heartburn

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect heartburn
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Notable - See study
A notable decrease in heartburn symptoms occurs after melatonin supplementation, thought to be related to a strengthening of the lower esophageal sphincter