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Bone Fracture Risk

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Summary of Bone Fracture Risk

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Bone Fracture Risk

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect bone fracture risk.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Minor - See study
A decrease in bone fracture risk (nonvetebral and hip) appears to exist when supplemental doses of Vitamin D3 are taken above 800 IU, with this protective effect being highly correlated with the improvement in functionality and fall reduction risk
grade-c Notable Very High See 2 studies
The decrease in fracture risk seen with vitamin K supplementation in susceptible cohorts appears to be greater than seen with other supplements