Vitamin B5
•Last Updated: September 28 2022
Pantothenic acid is one of the B-vitamins which is critical in the formation of Co-enzyme A, a molecule which helps a large amount of enzymes function in the body, and for energy production in general. While it is important, it is rare to be deficient and further supplementation shows little promise.
Vitamin B5 is most often used for
Last Updated: September 28 2022
Note that Vitamin B5 is also known as:
- Pantothenic acid
- Panthenol
- Pantothenate
- Dexpanthenol
- Pantothenylalcohol
Research feed
Recent evidence has linked B vitamins (specifically B6 and B12) to an increased risk of lung cancer in men, especially in smokers. Here, we analyze the study and interview the lead author, Dr. Theodore Brasky.
B vitamins are common ingredients of multivitamins, of course, but also of energy boosters, such as energy drinks. But while they are best known for their role in energy metabolism,[57] they may play a role in cancer biology through partaking in one-carbon metabolism[58] and thus in methylation reactions and DNA synthesis.
This hypothesis was substantiated in 2015 when a paper published by the New England Journal of Medicine caused a stir by reporting that nicotinamide (a form of vitamin B3 also known as niacinamide) could reduce the rate of new non-melanoma skin cancers...
1.^Institute of MedicineDietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline.(1998)
2.^Ren XN et al.Application of UPLC-MS/MS Method for Analyzing B-vitamins in Human MilkBiomed Environ Sci.(2015)
3.^Song WO et al.Effect of pantothenic acid status on the content of the vitamin in human milkAm J Clin Nutr.(1984)
4.^Schroeder HALosses of vitamins and trace minerals resulting from processing and preservation of foodsAm J Clin Nutr.(1971)
6.^Leonardi R et al.Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domainChem Biol.(2010)
8.^Yao J, Dotson GDKinetic characterization of human phosphopantothenoylcysteine synthetaseBiochim Biophys Acta.(2009)
9.^Strauss E et al.Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agentBiochemistry.(2004)
10.^de Jonge BL et al.Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapyAntimicrob Agents Chemother.(2013)
11.^Gudkova D et al.EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthaseFEBS Lett.(2012)
12.^Wittwer CT et al.Mild pantothenate deficiency in rats elevates serum triglyceride and free fatty acid levelsJ Nutr.(1990)
13.^Shibata K et al.Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumptionNutrition.(2013)
14.^Hurley LS, Mackenzie JBAdrenal function in the pantothenic acid-deficient rat; liver glycogen, blood glucose, adrenal cholesterol and adrenal ascorbic acid levelsJ Nutr.(1954)
15.^Yamamoto T et al.Effects of pantothenic acid on testicular function in male ratsJ Vet Med Sci.(2009)
16.^Barboriak JJ et al.Effect of partial pantothenic acid deficiency on reproductive performance of the ratJ Nutr.(1957)
17.^Reibel DK, Wyse BW, Berkich DA, Neely JRCoenzyme A metabolism in pantothenic acid-deficient ratsJ Nutr.(1982)
18.^Srinivasan V, Belavady BAlterations in gluconeogenesis in experimental pantothenic acid deficiencyIndian J Biochem Biophys.(1976)
19.^Olson RE, Kaplan NOThe effect of pantothenic acid deficiency upon the coenzyme A content and pyruvate utilization of rat and duck tissuesJ Biol Chem.(1948)
20.^Vaxman F et al.Can the wound healing process be improved by vitamin supplementation? Experimental study on humansEur Surg Res.(1996)
21.^Gehring W, Gloor MEffect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo studyArzneimittelforschung.(2000)
22.^Abiko Y, Tomikawa M, Shimizu MEnzymatic conversion of pantothenylalcohol to pantothenic acidJ Vitaminol (Kyoto).(1969)
23.^Ebner F, Heller A, Rippke F, Tausch ITopical use of dexpanthenol in skin disordersAm J Clin Dermatol.(2002)
24.^Shibata K, Gross CJ, Henderson LMHydrolysis and absorption of pantothenate and its coenzymes in the rat small intestineJ Nutr.(1983)
25.^Said HM et al.Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acidAm J Physiol.(1998)
26.^Said HMRecent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreasAm J Physiol Gastrointest Liver Physiol.(2013)
27.^Ghosal A et al.Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorptionAm J Physiol Gastrointest Liver Physiol.(2013)
28.^Balamurugan K, Ortiz A, Said HMBiotin uptake by human intestinal and liver epithelial cells: role of the SMVT systemAm J Physiol Gastrointest Liver Physiol.(2003)
31.^Takahashi K, Fukuwatari T, Shibata KExercise and a High Fat Diet Synergistically Increase the Pantothenic Acid Requirement in RatsJ Nutr Sci Vitaminol (Tokyo).(2015)
32.^Lewis CM, King JCEffect of oral contraceptives agents on thiamin, riboflavin, and pantothenic acid status in young womenAm J Clin Nutr.(1980)
33.^Uchida Y et al.Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cellsJ Neurochem.(2015)
34.^Spector RPantothenic acid transport and metabolism in the central nervous systemAm J Physiol.(1986)
35.^Spector RDevelopment and Characterization of Pantothenic Acid Transport in BrainJ Neurochem.(1986)
36.^Spector R, Johanson CEVitamin transport and homeostasis in mammalian brain: focus on Vitamins B and E2007.(2007)
38.^Bremer J, Wojtczak ABFactors controlling the rate of fatty acid -oxidation in rat liver mitochondriaBiochim Biophys Acta.(1972)
39.^Wall BT et al.Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humansJ Appl Physiol (1985).(2012)
40.^Sahlin K, Sallstedt EK, Bishop D, Tonkonogi MTurning down lipid oxidation during heavy exercise--what is the mechanism?J Physiol Pharmacol.(2008)
42.^Stephens FB et al.New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscleJ Physiol.(2007)
43.^Slyshenkov VS, Rakowska M, Moiseenok AG, Wojtczak LPantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidationFree Radic Biol Med.(1995)
44.^Machado MV et al.Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse ModelDig Dis Sci.(2016)
46.^Jillian L. CapodiceFeasibility, Tolerability, Safety and Efficacy of a Pantothenic Acid Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne BlemishesJ Cosmetics, Dermatology Science and Applications.(2012)
47.^Yang M et al.A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acneDermatol Ther (Hejdelb).(2014)
48.^Vaxman F et al.Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. A double-blind, prospective and randomized trialEur Surg Res.(1995)
49.^Proksch E, Nissen HPDexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritationJ Dermatolog Treat.(2002)
50.^Romiti R, Romiti NDexpanthenol cream significantly improves mucocutaneous side effects associated with isotretinoin therapyPediatr Dermatol.(2002)
53.^Schmidt VThe excretion of pantothenic acid in patients with achromotrichia and alopeciaJ Gerontol.(1951)
54.^Miyazaki A, Sano M, Fukuwatari T, Shibata KEffects of ethanol consumption on the B-group vitamin contents of liver, blood and urine in ratsBr J Nutr.(2012)
55.^Sorrell MF, Baker H, Barak AJ, Frank ORelease by ethanol of vitamins into rat liver perfusatesAm J Clin Nutr.(1974)
56.^Israel BC, Smith CMEffects of acute and chronic ethanol ingestion on pantothenate and CoA status of ratsJ Nutr.(1987)
Primary Use
Cardiovascular Health