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Ursolic Acid

Ursolic Acid is a molecule found in apple peels, and in the Ayurveda herb known as Holy Basil. No human interventions exist right now, but ursolic acid appears to be a promising body recomposition agent; able to increase muscle mass and decrease fat mass. May be anti-fertility, however.

Our evidence-based analysis on ursolic acid features 64 unique references to scientific papers.

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Summary of Ursolic Acid

Primary Information, Benefits, Effects, and Important Facts

Ursolic acid is a phytochemical found in a wide variety of plants but most well known for being in apple peels.

Although the science is preliminary, it seems to be able to reduce fat accumulation and increase muscle mass gain when in a fed state, and to induce fat burning and preserve muscle mass when in a fasted state.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Animal studies have found benefits with ursolic acid in the diet at 0.05-0.2% of the diet, which is around 10-40mg/kg (based on their weight and food intake) and the estimated human dose equivalent to this is 1.6-6.4mg/kg bodyweight; for a 150lb adult it would be the range of 110-440mg.

The lone human study used the higher end of this range, 150mg three times a day with meals totalling 450mg each day, and found some biological acitivty. Until further research arises, thrice daily dosing of 150mg with meals is recommended.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects ursolic acid has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor - See study
An increase in IGF-1 concentrations has been noted with supplementation of ursolic acid three times daily (150mg) in exercising subjects.
grade-c Minor - See study
An increase in serum Irisin has been noted with 150mg ursolic acid three times a day in exercising individuals.
grade-c Minor - See study
As measured by peak torque (isokinetically), ursolic acid supplementation may increase power output in trained individuals.
grade-c - - See study
Ursolic acid with meals in athletic subjects has failed to alter fasting glucose concentrations relative to placebo.
grade-c - - See study
No significant reductions in fat mass were noted when ursolic acid (150mg thrice daily over 16 weeks) was used, when compared to placebo.
grade-c - - See study
No alterations in insulin concentrations are noted with chronic ursolic acid supplementation.
grade-c - - See study
The increase in power output and IGF-1 seen with ursolic acid over 16 weeks was not accompanied by an increase in lean mass relative to control (resistance training was included).

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Things to Note

Other Functions:

Primary Function:

Also Known As

Apple peel extract

Do Not Confuse With

Usnic Acid

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Click here to see all 64 references.