Squalene

Last Updated: November 18 2022

Squalene is a compound found in Olive Oil and in high amounts in shark oil. It was touted as the reason sharks don't get cancer, until it was found that sharks can get cancer. Squalene however, remains an anti-cancer compound, is fairly healthy, and benefits cholesterol levels.

dosageDosage

Squalene is most often used for

Summary

Squalane is a nutritional compound found mostly in olive oil and shark oil, and to a lesser extent in wheat germ and rice bran. It can be consumed at high levels through the diet alone if consideration is paid, although supplementation can also help.

It helps protect the body against cancer and the effects of aging, and is generally well tolerated and safe.

Dosage information

A typical preventative dose to alleviate cancer risk would be in the range of 300mg a day, to mimic the dosages found in the mediterranean diet.

Dosages above this are well-tolerated.

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References
1.^Connolly JD, Hill RATriterpenoidsNat Prod Rep.(2010 Jan)
2.^Reddy LH, Couvreur PSqualene: A natural triterpene for use in disease management and therapyAdv Drug Deliv Rev.(2009 Dec 17)
3.^Nikkari T, Schreibman PH, Ahrens EH JrIn vivo studies of sterol and squalene secretion by human skinJ Lipid Res.(1974 Nov)
6.^Murkovic M, Lechner S, Pietzka A, Bratacos M, Katzogiannos EAnalysis of minor components in olive oilJ Biochem Biophys Methods.(2004 Oct 29)
7.^Allouche Y, Jiménez A, Gaforio JJ, Uceda M, Beltrán GHow heating affects extra virgin olive oil quality indexes and chemical compositionJ Agric Food Chem.(2007 Nov 14)
8.^Mathews JSharks still intrigue cancer researchersJ Natl Cancer Inst.(1992 Jul 1)
9.^Kelly GSSqualene and its potential clinical usesAltern Med Rev.(1999 Feb)
10.^Abe I, Tomesch JC, Wattanasin S, Prestwich GDInhibitors of squalene biosynthesis and metabolismNat Prod Rep.(1994 Jun)
12.^Tilvis RS, Miettinen TAAbsorption and metabolic fate of dietary 3H-squalene in the ratLipids.(1983 Mar)
15.^Gylling H, Miettinen TAPostabsorptive metabolism of dietary squaleneAtherosclerosis.(1994 Apr)
16.^Owen RW, Haubner R, Würtele G, Hull E, Spiegelhalder B, Bartsch HOlives and olive oil in cancer preventionEur J Cancer Prev.(2004 Aug)
17.^Waterman E, Lockwood BActive components and clinical applications of olive oilAltern Med Rev.(2007 Dec)
18.^Smith TJSqualene: potential chemopreventive agentExpert Opin Investig Drugs.(2000 Aug)
19.^Nakagawa M, Yamaguchi T, Fukawa H, Ogata J, Komiyama S, Akiyama S, Kuwano MPotentiation by squalene of the cytotoxicity of anticancer agents against cultured mammalian cells and murine tumorJpn J Cancer Res.(1985 Apr)
21.^Van Duuren BL, Goldschmidt BMCocarcinogenic and tumor-promoting agents in tobacco carcinogenesisJ Natl Cancer Inst.(1976 Jun)
23.^Senthilkumar S, Devaki T, Manohar BM, Babu MSEffect of squalene on cyclophosphamide-induced toxicityClin Chim Acta.(2006 Feb)
24.^Hashim YZ, Eng M, Gill CI, McGlynn H, Rowland IRComponents of olive oil and chemoprevention of colorectal cancerNutr Rev.(2005 Nov)
25.^Roman Nowicki, Wioletta Barańska-RybakShark liver oil as a supporting therapy in atopic dermatitisPol Merkur Lekarski.(2007 Apr)
26.^Buddhan S, Sivakumar R, Dhandapani N, Ganesan B, Anandan RProtective effect of dietary squalene supplementation on mitochondrial function in liver of aged ratsProstaglandins Leukot Essent Fatty Acids.(2007 Jun)
27.^Sabeena Farvin KH, Anandan R, Kumar SH, Shiny KS, Sankar TV, Thankappan TKEffect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in ratsPharmacol Res.(2004 Sep)
28.^Mesa C, Fernández LEChallenges facing adjuvants for cancer immunotherapyImmunol Cell Biol.(2004 Dec)
31.^Edelman RVaccine adjuvantsRev Infect Dis.(1980 May-Jun)
32.^Sotiroudis TG, Kyrtopoulos SAAnticarcinogenic compounds of olive oil and related biomarkersEur J Nutr.(2008 May)