Spilanthes acmella
Our evidence-based analysis on spilanthes acmella features 20 unique references to scientific papers.
Summary of Spilanthes acmella
Primary Information, Benefits, Effects, and Important Facts
Spilanthes Acmella (Toothache Plant, Paracress) is a food product that has some history of medicinal usage related to its pain relieving properties. As the bioactives are absorbed topically and the leaves are used in salads, consumption of salads have been touted to help toothaches and other oral diseases where pain is a side-effect thereof.
It is currently in preliminary stages of research right now, with no human evidence. In rats, these pain relieving effects do appear to exist when applied to the skin (no evidence on oral consumption) and are fairly potent, but underperformed when compared to the reference drug.
Other properties of Spilanthese Acmella are as an aphrodisiac (which appears to be quite potent in rats, building up in efficacy over time rather than acute effects) and the diuretic effect, which only has one study on it currently but exhibited more potent effects than furosemide. The mechanism of diuresis appears to be similar to a loop diuretic.
Additionally, Spilanthes has been found to increase testosterone, FSH, and LH; similar effects were also noted with another herb containing the same molecular class of N-Akylamides (Anacyclus Pyrethrum) but currently this is one study.
Get unbiased information on what works
At Examine.com, we pride ourselves on basing all our recommendations on evidence. It’s why we don’t sell any advertising or supplements — so that you know that our analysis is unbiased.
If you’re tired of wasting time and money on supplements that don’t work, our 17 Supplement Guides will help you figure out precisely what to take — and what to skip — based on your health goals and the latest scientific evidence.
Join over 50,000 people who rely on Examine.com's unbiased and science-based analysis.
I want unbiased recommendations »
Based on the evidence in rats using 150mg/kg of an ethanolic extract, an estimated human dose is:
1,600mg for a 150lb person
2,200mg for a 200lb person
2,700mg for a 250lb person
Things to Note
Is a Form Of
Primary Function:
Also Known As
Jambu Oleoresin, Acmella oleracea, Spilanthes oleracea, toothache plant, paracress
Most bioactives in Spilanthes Acmella appear to be highly polar and may need food to be absorbed
Take care when consuming Spilanthes Acmella with alcohol: may increase ethanol sensivity via inhibition of the enzyme CYP2E1
Tired of misinformation? Get unbiased info on supplements.
At Examine.com, our incentives line up with yours — getting unbiased information. It’s why we don’t sell any advertising or supplements.
Join over 250,000 people who’ve learned about effective versus overrated supplements, supplement buying tips, and how to combine supplements for safety and efficacy.
Click here to see all 20 references.
