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All Essential Benefits/Effects/Facts & Information
Rhamnus Nakaharai is a taiwanese medicine historically used for gastrointestinal ailments. It belongs to the Rhamnus species of plants of which variations are grown globally. Rhamnus Nakaharai is a source of various phytonutrients (plant based nutrients) particularly, it is a fairly good source of Quercetin.
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How to Take
Recommended dosage, active amounts, other details
Not enough information is known about Rhamnus Nakaharai to come to a conclusion on proper dosages.
Editors' Thoughts on Rhamnus nakaharai
Rhamnus Nakaharai just appears to be a vessel for 3-O-Methylquercetin. It seems to be marketed as a test booster form a company, but I cannot find any information on it affecting testosterone levels.
Table of Contents:
Sources and composition
Sources and History
Interactions with Oxidation
Inflammation and Immunology
1.1. Sources and History
Rhamnus Nakaharia (from the family Rhamnaceae) is a folk medicine originating in Taiwan that has been used to treat constipation, inﬂammation, malignant tumors, and asthma.
Rhamnus Nakaharai (RN) is a Taiwanese herbal medicine that contains:
The napthalenic compound 6-methoxysorigenin and various glycosides and acylates of the parent compound, such as alpha-sorinin although 6-methoxyorigenin appears to be isolated from the wood component of the herb
Isotorachyrsone and derivatives.
Quercetin glycosides, specifically 3-O-Methylquercetin.
2Interactions with Oxidation
The compound 6-methoxyorigenin appears to have anti-oxidative effects in vitro, as well as the related compound Isotorachrysone, which share structural similarities. 6-methoxygenin outperformed Trolox (a research standard) on Metal-chelating and protecting from lipid peroxidation, and was slightly outperformed on a DPPH test. The IC50 of the metal chelating ability of 6-methoxyorigenin (615.90+/-5.79) was lesser than that of EDTA (127.92+/-6.27).
3Inflammation and Immunology
3-O-Methylquercetin has been found to suppress the inflammatory (Nitric Oxide mediated) response from LPS (research pro-inflammatory agent) in macrophages in vitro. 3-O-Methylquercetin was found to inhibit Nitric Oxide release, protein expression of iNOS (induced by inflammation) and mRNA translation of iNOS with IC50 values of 4.23uM, 4.36uM, and 6.53uM respectively.
3-O-Methylquercetin appears to be a selective PDE3 inhibitor with an IC50 of 1.6mM via competitive inhibition.
Scientific Support & Reference Citations
Ng LT, Lin CC, Lu CM Antioxidative effects of 6-methoxysorigenin and its derivatives from Rhamnus nakaharai
. Chem Pharm Bull (Tokyo). (2007)
Lin CN, et al Novel antiplatelet naphthalene from Rhamnus nakaharai
. J Nat Prod. (1995)
Hsiao G, et al Antioxidant properties of isotorachrysone isolated from Rhamnus nakaharai
. Biochim Biophys Acta. (1996)
Jiang JS, et al Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells
. J Ethnopharmacol. (2006)
Ko WC, et al 3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3
. Planta Med. (2003)
(Common misspellings for Rhamnus nakaharai include ramnus, rhamus, rhamnis, rhamis, ramnis, nakahara, nakahari)