Summary of Rhamnus nakaharai
Primary Information, Benefits, Effects, and Important Facts
Rhamnus Nakaharai is a taiwanese medicine historically used for gastrointestinal ailments. It belongs to the Rhamnus species of plants of which variations are grown globally. Rhamnus Nakaharai is a source of various phytonutrients (plant based nutrients) particularly, it is a fairly good source of Quercetin.
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How to Take
Recommended dosage, active amounts, other details
Not enough information is known about Rhamnus Nakaharai to come to a conclusion on proper dosages.
Table of Contents:
Sources and composition
Sources and History
Interactions with Oxidation
Inflammation and Immunology
1.1. Sources and History
Rhamnus Nakaharia (from the family Rhamnaceae) is a folk medicine originating in Taiwan that has been used to treat constipation, inﬂammation, malignant tumors, and asthma.
Rhamnus Nakaharai (RN) is a Taiwanese herbal medicine that contains:
The napthalenic compound 6-methoxysorigenin and various glycosides and acylates of the parent compound, such as alpha-sorinin although 6-methoxyorigenin appears to be isolated from the wood component of the herb
Isotorachyrsone and derivatives.
Quercetin glycosides, specifically 3-O-Methylquercetin.
2Interactions with Oxidation
The compound 6-methoxyorigenin appears to have anti-oxidative effects in vitro, as well as the related compound Isotorachrysone, which share structural similarities. 6-methoxygenin outperformed Trolox (a research standard) on Metal-chelating and protecting from lipid peroxidation, and was slightly outperformed on a DPPH test. The IC50 of the metal chelating ability of 6-methoxyorigenin (615.90+/-5.79) was lesser than that of EDTA (127.92+/-6.27).
3Inflammation and Immunology
3-O-Methylquercetin has been found to suppress the inflammatory (Nitric Oxide mediated) response from LPS (research pro-inflammatory agent) in macrophages in vitro. 3-O-Methylquercetin was found to inhibit Nitric Oxide release, protein expression of iNOS (induced by inflammation) and mRNA translation of iNOS with IC50 values of 4.23uM, 4.36uM, and 6.53uM respectively.
3-O-Methylquercetin appears to be a selective PDE3 inhibitor with an IC50 of 1.6mM via competitive inhibition.
Scientific Support & Reference Citations
Ng LT, Lin CC, Lu CM.
Antioxidative effects of 6-methoxysorigenin and its derivatives from Rhamnus nakaharai.
Chem Pharm Bull (Tokyo). (2007)
Lin CN, et al.
Novel antiplatelet naphthalene from Rhamnus nakaharai.
J Nat Prod. (1995)
Hsiao G, et al.
Antioxidant properties of isotorachrysone isolated from Rhamnus nakaharai.
Biochim Biophys Acta. (1996)
Jiang JS, et al.
Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells.
J Ethnopharmacol. (2006)
Ko WC, et al.
3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3.
Planta Med. (2003)
(Common misspellings for Rhamnus nakaharai include ramnus, rhamus, rhamnis, rhamis, ramnis, nakahara, nakahari)
Cite this page
"Rhamnus nakaharai," Examine.com, published on 30 September 2013, last updated on
14 June 2018,