Phellodendron amurense

Last Updated: September 28 2022

Phellodendron Amurense (PA), also known as CorkTree, is a chinese herb used to historically treat different forms of inflammation and bone pain. There is not too much Western research on this herb.

Phellodendron amurense is most often used for


Phellodendron Amurense (PA), also known as CorkTree, is a chinese herb used to historically treat different forms of inflammation and bone pain.

As a plant, it contains a few potent chemicals which exert pharmacological-like properties and is of interest as a treatment for various disease states.

What else is Phellodendron amurense known as?
Note that Phellodendron amurense is also known as:
  • Rutaceae
  • Amur Cork Tree
  • Kihada
  • Nexrutine
  • Corktree
  • Huangbai
Dosage information

Although there is not enough evidence to suggest an optimal dosage, a dose of 250-500mg taken twice a day with meals is usually advocated.

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      1.^Chen ML, Xian YF, Ip SP, Tsai SH, Yang JY, Che CTChemical and biological differentiation of Cortex Phellodendri Chinensis and Cortex Phellodendri AmurensisPlanta Med.(2010 Oct)
      6.^Miyake M, Inaba N, Ayano S, Ozaki Y, Maeda H, Ifuku Y, Hasegawa SLimonoids in Phellodendron amurense (Kihada)Yakugaku Zasshi.(1992 May)
      7.^Steinmann D, Baumgartner RR, Heiss EH, Bartenstein S, Atanasov AG, Dirsch VM, Ganzera M, Stuppner HBioguided isolation of (9Z)-octadec-9-enoic acid from Phellodendron amurense Rupr. and identification of fatty acids as PTP1B inhibitorsPlanta Med.(2012 Feb)
      8.^Wang H, Li SY, Zhao CK, Zeng XA system for screening agonists targeting beta2-adrenoceptor from Chinese medicinal herbsJ Zhejiang Univ Sci B.(2009 Apr)
      9.^Oben J, Enonchong E, Kothari S, Chambliss W, Garrison R, Dolnick DPhellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled studyNutr J.(2009 Aug 14)
      10.^Kim JH, Huh JE, Baek YH, Lee JD, Choi DY, Park DSEffect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytesJ Ethnopharmacol.(2011 Mar 24)
      11.^Lee HW, Suh JH, Kim HN, Kim AY, Park SY, Shin CS, Choi JY, Kim JBBerberine promotes osteoblast differentiation by Runx2 activation with p38 MAPKJ Bone Miner Res.(2008 Aug)
      14.^Kim IG, Kang SC, Kim KC, Choung ES, Zee OPScreening of estrogenic and antiestrogenic activities from medicinal plantsEnviron Toxicol Pharmacol.(2008 Jan)
      16.^Sufka KJ, Roach JT, Chambliss WG Jr, Broom SL, Feltenstein MW, Wyandt CM, Zeng LAnxiolytic properties of botanical extracts in the chick social separation-stress procedurePsychopharmacology (Berl).(2001 Jan 1)