Last Updated: September 28 2022

Pelargonidin is one of the six anthocyanin compounds, and is both the simplest in structure and is red. It is commonly associated with strawberries, although it is present in all berries. Seems to have its bioactivity saved by Quercetin.

Pelargonidin is most often used for

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Sources and Structure

Pelargonidin is the simplest of the Anthocyanins as it does not have any additions to the two possible side-chains (see Anthocyanins page for explanation). It is found in various foods in the anthocyanin spectrum, but is found in relatively high levels in strawberries.[1][2]



Digestion, Metabolism, and Pharmacokinetics


Digestion and Bioavailability

While Pelargonidin aglycones appear to be rapidly degraded or conjugated (via glucuronides), the common food bound form Pelargonidin-3-Glucoside appears to be stable in a model of human digestion.[3]

Oral bioavailability of Pelargonidin appears to be 18% when measured after two hours.[4] It is essentially cleared from the body 18 hours after ingestion, although p-hydroxybenzoic acid (a metabolite) persists.[4] This particular study used 50mg/kg bodyweight Pelargonidin in a 50% aqueous ethanol solution. Food sources of Pelargonidin may not be as bioavailable as the former (isolated form) as one study in humans found that urinary levels after 24 hours accounted for 0.9% the oral dose.[5]

Despite the above, some authors[6] suggest that Pelargonidin has the highest absorption rates of all anthocyanins.[7][8]

Consuming Pelargonidin (from food sources) alongside a fat source does not appear to increase overall amounts of Pelargonidin absorbed, although it delays the time it takes to absorb by slowing gastric digestion.[9]


Organ tracing; where it ends up

One study in rats[4] found that, after pelargonidin gavage (directly into gut through mouth) that pelargonidin was detectable in brain and lung tissue as itself at around 0.16nmol/g, and was detectable in serum, lungs, and kidneys as pelargonidin glucuronide.


Metabolites of Pelargonidin

Pelargonidin is subject to P450 enzymes in the liver, and primarily exists in plasma as Pelargonidin Glucuronide.[8][4] This has also been found in humans after consuming Pelargonidin containing foods.[10][8] Some sulfate conjugates (Pelargonidin Sulfate) have been noted with urinary excretion[11] although they are insignificant enough to sometimes not be recorded.[7]

Colonic production of p-hydroxybenzoic acid, a ring fission product of pelargonidin, has been noted in plasma 2 hours after oral ingestion and accounting for 44% of the oral dose.[4] Direct conversion has been noted, but also indirect breaking to p-hydroxy propinoic acid with subsequent B-oxidation to p-hydroxybenzoic acid.[4] 18 hours post ingestion, this is the only metabolite of Pelargonidin present.[4]


Effects on Glucose Metabolism and Diabetes


In vitro


In vivo

Pelargonidin, when fed to rats (10mg/kg bodyweight) after a diabetic toxin, was able to mostly alleviate the progression of hyperalgesia over time; multiple doses were able to reduce markers of oxidation, indicating anti-oxidant capabilities.[12] Anti-oxidation was also seen in an I.V study (3mg/kg bodyweight) as levels of superoxide dismutase and catalase (endogenous antioxidant enzymes) were restored in diabetic rats.[13] Anti-oxidative effects at 10-20mg/kg bodyweight have also been implicated in neuroprotection.[14]

Injections have been shown to reduce blood glucose levels and increase serum insulin, and subsequently reduce the amount of hemoglobin glycation that occurs.[13]

Contrary to the above, one animal study[6] noted that freeze-dried berry extracts seemed to promote weight-gain when given through an obesogenic diet, whereas a purified anthocyanin mixture had the expected triglyceride lowering results.[6]

In adult humans, the addition of Pelargonidin (as Strawberries) to a meal was able to decrease the post-prandial (after meal) inflammation and insulin spike.[1] From strawberries, there appears to be a linear response for absorption.[15][8] This may be due to, in part, Pelargonidin's ability to prevent glucose uptake into the intestinal wall.[16]


Skin Interactions

One study put forth using Strawberry Extract, mostly consisting of Pelargonidin and its glycosides, was able to protect human skin cells in vitro from UV(A) rays and less DNA damage at concentrations from 0.05mg/mL to 0.5mg/mL .[17]


Synergism and Antagonism

One study, when investigating phenolics in strawberries and how they interacted with each other[2] found that Pelargonidin reduces the anti-oxidant potential of the (normally) synergistic mixture of p-coumaric acid and catechin, explained by the large amount of Pelargonidin present sequestering electrons being donated from catechin to p-coumaric acid.[2] This study used concentrations found in strawberries, and not 1:1 ratios. Pelargonidin was also noted to act antagonistically with Cyanidin aglycones and with p-coumaric acid alone. However, when paired with Quercetin these latter two antagonisms were reversed into a synergistic relationship, due to Quercetin's lower reduction potential relative to Pelargonidin.[2][18][19]

1.^Edirisinghe I, Banaszewski K, Cappozzo J, Sandhya K, Ellis CL, Tadapaneni R, Kappagoda CT, Burton-Freeman BMStrawberry anthocyanin and its association with postprandial inflammation and insulinBr J Nutr.(2011 Sep)
4.^El Mohsen MA, Marks J, Kuhnle G, Moore K, Debnam E, Kaila Srai S, Rice-Evans C, Spencer JPAbsorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to ratsBr J Nutr.(2006 Jan)
5.^Azzini E, Vitaglione P, Intorre F, Napolitano A, Durazzo A, Foddai MS, Fumagalli A, Catasta G, Rossi L, Venneria E, Raguzzini A, Palomba L, Fogliano V, Maiani GBioavailability of strawberry antioxidants in human subjectsBr J Nutr.(2010 Oct)
6.^Prior RL, Wu X, Gu L, Hager T, Hager A, Wilkes S, Howard LPurified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat dietMol Nutr Food Res.(2009 Nov)
11.^Felgines C, Talavéra S, Gonthier MP, Texier O, Scalbert A, Lamaison JL, Rémésy CStrawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humansJ Nutr.(2003 May)
12.^Mirshekar M, Roghani M, Khalili M, Baluchnejadmojarad T, Arab Moazzen SChronic oral pelargonidin alleviates streptozotocin-induced diabetic neuropathic hyperalgesia in rat: involvement of oxidative stressIran Biomed J.(2010 Jan-Apr)
14.^Roghani M, Niknam A, Jalali-Nadoushan MR, Kiasalari Z, Khalili M, Baluchnejadmojarad TOral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonismBrain Res Bull.(2010 Jul 30)
15.^Hollands W, Brett GM, Dainty JR, Teucher B, Kroon PAUrinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruitMol Nutr Food Res.(2008 Oct)
19.^Foley S, Navaratnam S, McGarvey DJ, Land EJ, Truscott TG, Rice-Evans CASinglet oxygen quenching and the redox properties of hydroxycinnamic acidsFree Radic Biol Med.(1999 May)