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Octopamine

A metabolite of synephrine, Octopamine is a stimulant compound that is also thought to have minor fat burning effects. Banned by WADA due to its stimulatory properties, the direct fat burning claims may not be relevant and are effectively untested in humans.

Our evidence-based analysis on octopamine features 66 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects octopamine has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor Very High See all 3 studies
There appears to be mild benefit in stress incident female incontinence with thrice daily dosing of octopamine between 15-30mg, with up to a quarter of subjects reporting full continence from supplementation.

Studies Excluded from Consideration

  • Confounded with other fat loss supplements[1]

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Things to Note

Other Functions:

Also Known As

Norsynephrine, p-hydroxyphenylethanolamine, β-hydroxytyramine, Norphen, Norsympatol, norfenefrine

Caution Notice

Banned by WADA

  • Octopamine is on the 2014 WADA banned substance list

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Click here to see all 66 references.