Last Updated: November 18 2022

Ziziphus Jujuba (Chinese/Korean Date, Jujube) is a plant which bears fruits and seeds that are used for medicinal purposes in Traditional Chinese Medicine. It may possess anxiety-reducing and sedative properties.

Jujube is most often used for


Ziziphus Jujuba is a fruit used in Traditional Chinese Medicine for purposes related to gastrointestinal health and digestion, as well as being a combination sedative/anxiolytic/pain-killer. It has apparently potent benefits according to Traditional Chinese Medicine, but there is limited human evidence and evidence in general on the benefits of Ziziphus Jujuba.

It appears to be pro-motility in regards to the intestines, speeding up transit time and encouraging defecation. This is associated with an increase in intestinal short chain fatty acids (SCFAs) and an increase in fecal moisture content, so it may be 'healthier' than other laxatives (to stretch the usage of the term 'healthy').

In rats fed high doses of Jujube, the sedative and anxiety-reducing effects appear to actually be quite potent with at least one study noting that there is similar potency to Diazepam, and the sedative properties may be synergistic with 5-HTP. There are currently no human studies on the sedative or anxiety-reducing effects of Jujube.

Traditional usage suggests Jujube may be anti-fertility for females, and a single rat study appears to find similar effects (although did not measure actual conception rates, just uterus size and estrus); it would be prudent to avoid usage of Jujube if trying to conceive a child.

What else is Jujube known as?
Note that Jujube is also known as:
  • Ziziphus Jujuba
  • Chinese Date
  • Da Zao
  • Jujube
Jujube should not be confused with:
Dosage information

Traditional usage of Jujube is taking 50g of the fruits (20 individual 2-2.5cm diameter fruits) and doing a hot water extract, either a soup of a beverage.

There currently is not enough evidence in humans to establish an effective oral dose of Zizyphus Jujube supplements but estimating from animal studies finding benefits with 500mg/kg for anxiety reduction, an estimated human dose would be:

  • 5,500 mg for a 150lb person
  • 7,300 mg for a 200lb person
  • 9,000 mg for a 250lb person

...for an ethanolic extract with a 23.34% extract yield.

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2.^Kubota H, Morii R, Kojima-Yuasa A, Huang X, Yano Y, Matsui-Yuasa IEffect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytesAm J Chin Med.(2009)
3.^Ahmad B, Khan I, Bashir S, Azam S, Ali NThe antifungal, cytotoxic, antitermite and insecticidal activities of Zizyphus jujubePak J Pharm Sci.(2011 Oct)
4.^Tetali P, Waghchaure C, Daswani PG, Antia NH, Birdi TJEthnobotanical survey of antidiarrhoeal plants of Parinche valley, Pune district, Maharashtra, IndiaJ Ethnopharmacol.(2009 Jun 22)
6.^Seo EJ, Lee SY, Kang SS, Jung YSZizyphus jujuba and its Active Component Jujuboside B Inhibit Platelet AggregationPhytother Res.(2012 Aug 15)
7.^Liu QX, Wang B, Liang H, Zhao YY, Liu MJStructure identification of jujuboside DYao Xue Xue Bao.(2004 Aug)
8.^Bai YJ, Cheng G, Tao J, Wang B, Zhao YY, Liu Y, Ma LB, Tu GZStructure identification of jujuboside EYao Xue Xue Bao.(2003 Dec)
9.^Pandey MB, Singh AK, Singh JP, Singh VP, Pandey VBThree new cyclopeptide alkaloids from Zizyphus speciesJ Asian Nat Prod Res.(2008 Jul-Aug)
11.^Niu JW, Zhang QW, Gong MX, Yan LH, Zhu JJ, Wang ZM, Li QFDetermination of zizybeoside II of Ziziphus jujuba by HPLCZhongguo Zhong Yao Za Zhi.(2008 Dec)
12.^Guo S, Duan JA, Tang YP, Yang NY, Qian DW, Su SL, Shang EXCharacterization of triterpenic acids in fruits of ziziphus species by HPLC-ELSD-MSJ Agric Food Chem.(2010 May 26)
14.^Lee SM, Park JG, Lee YH, Lee CG, Min BS, Kim JH, Lee HKAnti-complementary activity of triterpenoides from fruits of Zizyphus jujubaBiol Pharm Bull.(2004 Nov)
15.^Fujiwara Y, Hayashida A, Tsurushima K, Nagai R, Yoshitomi M, Daiguji N, Sakashita N, Takeya M, Tsukamoto S, Ikeda TTriterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophagesJ Agric Food Chem.(2011 May 11)
19.^Yano T, Ohmori K, Takahashi H, Kusumi T, Suzuki KUnified approach to catechin hetero-oligomers: first total synthesis of trimer EZ-EG-CA isolated from Ziziphus jujubaOrg Biomol Chem.(2012 Sep 12)
20.^Akhmedov UA, Khalmatov KhKhIsolation of rutin from the leaves of Zizyphus jujuba MillFarmatsiia.(1967 May-Jun)
22.^Li M, Yang GL, Mi S, Gao XY, Wang Y, Li MRExtract process of cyclic adenosinemonophosphate (cAMP) in Ziziphus jujubaZhong Yao Cai.(2007 Sep)
23.^Guo S, Duan JA, Tang YP, Zhu ZH, Qian YF, Yang NY, Shang EX, Qian DWCharacterization of nucleosides and nucleobases in fruits of Ziziphus jujuba by UPLC-DAD-MSJ Agric Food Chem.(2010 Oct 13)
30.^Peng WH, Hsieh MT, Lee YS, Lin YC, Liao JAnxiolytic effect of seed of Ziziphus jujuba in mouse models of anxietyJ Ethnopharmacol.(2000 Oct)
31.^Costall B, Jones BJ, Kelly ME, Naylor RJ, Tomkins DMExploration of mice in a black and white test box: validation as a model of anxietyPharmacol Biochem Behav.(1989 Mar)
32.^Yeung WF, Chung KF, Man-Ki Poon M, Yan-Yee Ho F, Zhang SP, Zhang ZJ, Tat-Chi Ziea E, Wong VTChinese herbal medicine for insomnia: A systematic review of randomized controlled trialsSleep Med Rev.(2012 Dec)
34.^Cao JX, Zhang QY, Cui SY, Cui XY, Zhang J, Zhang YH, Bai YJ, Zhao YYHypnotic effect of jujubosides from Semen Ziziphi SpinosaeJ Ethnopharmacol.(2010 Jul 6)
37.^Hwang IK, Yoo KY, Yoo DY, Choi JH, Lee CH, Kang IJ, Kwon DY, Kim YS, Kim DW, Won MHZizyphus enhances cell proliferation and neuroblast differentiation in the subgranular zone of the dentate gyrus in middle-aged miceJ Med Food.(2011 Mar)
38.^Yoo KY, Li H, Hwang IK, Choi JH, Lee CH, Kwon DY, Ryu SY, Kim YS, Kang IJ, Shin HC, Won MHZizyphus attenuates ischemic damage in the gerbil hippocampus via its antioxidant effectJ Med Food.(2010 Jun)
39.^Zhang M, Ning G, Shou C, Lu Y, Hong D, Zheng XInhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampusPlanta Med.(2003 Aug)
42.^Shou C, Feng Z, Wang J, Zheng XThe inhibitory effects of jujuboside A on rat hippocampus in vivo and in vitroPlanta Med.(2002 Sep)
45.^Naftali T, Feingelernt H, Lesin Y, Rauchwarger A, Konikoff FMZiziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trialDigestion.(2008)
47.^Al-Reza SM, Yoon JI, Kim HJ, Kim JS, Kang SCAnti-inflammatory activity of seed essential oil from Zizyphus jujubaFood Chem Toxicol.(2010 Feb)
48.^Li J, Shan L, Liu Y, Fan L, Ai LScreening of a functional polysaccharide from Zizyphus Jujuba cv. Jinsixiaozao and its propertyInt J Biol Macromol.(2011 Oct 1)
49.^Kim IG, Kang SC, Kim KC, Choung ES, Zee OPScreening of estrogenic and antiestrogenic activities from medicinal plantsEnviron Toxicol Pharmacol.(2008 Jan)
50.^Yoon JI, Al-Reza SM, Kang SCHair growth promoting effect of Zizyphus jujuba essential oilFood Chem Toxicol.(2010 May)
51.^Huang X, Kojima-Yuasa A, Xu S, Norikura T, Kennedy DO, Hasuma T, Matsui-Yuasa IGreen tea extract enhances the selective cytotoxic activity of Zizyphus jujuba extracts in HepG2 cellsAm J Chin Med.(2008)
53.^Liu SH, Cheng YCOld formula, new Rx: the journey of PHY906 as cancer adjuvant therapyJ Ethnopharmacol.(2012 Apr 10)
55.^Chan AS, Yip EC, Yung LY, Pang H, Luk SC, Pang SF, Wong YHCKBM stimulates MAPKs but inhibits LPS-induced IFN-gamma in lymphocytesPhytother Res.(2006 Sep)
56.^Gupta M, Mazumder UK, Vamsi ML, Sivakumar T, Kandar CCAnti-steroidogenic activity of the two Indian medicinal plants in miceJ Ethnopharmacol.(2004 Jan)