St. John's Wort (Hypericum perforatum) is a herb which, through the active component hypericin, works as a dopamine-related anti-depressant and is effective at doing so. This is also the prototypical 'adverse drug-interaction' herb; it interacts with several compounds by affecting the several phase I enzymes as well as other drug elimination pathways.
Summary of Hypericum perforatum
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Things to Note
Also Known As
St. John's Wort
St. John's Wort interferes with the elimination of several drugs and supplements. It is a significant CYP3A4 inducer, and should not be used with pharmaceuticals or supplements that are metabolized by this enzyme (like berberine). Consult a medical professional before supplementation of St. John's Wort if you are taking any drugs or supplements.
St. John's Wort induces (increases the amount of) CYP3A4, and should not be used by pharmaceuticals that are metabolized by this enzyme
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