Higenamine
Higenamine (Norcoclaurine) is part of the Nandina plant that has traditionally been used as an anti-asthmatic and is currently used as a fat burner due to sharing similar mechanisms to ephedrine; limited evidence on these claims.
Higenamine is most often used for
Last Updated:September 28, 2022
Higenamine is a molecule derived from a variety of fruits and plants that appears to have anti-asthmatic properties via dilating the bronchial tubes (a mechanism known as Beta(2)adrenergic agonism). This mechanism is also the same one underlying the fat burning potential of ephedrine, and as such Higenamine is currently being used as a fat burner.
Currently, there is no human evidence using Higenamine and it appears to be similarly potent to some established beta(2)adrenergic agonists in preliminary studies (in regards to anti-asthmatic effects).
Beyond that mechanism, it may also exert anti-inflammatory effects and injections may be useful in a clinical setting against sepsis.
Higenamine is on the FDA's Dietary Supplement Ingredient Advisory List as of April, 2019. These are ingredients that do not appear to be lawful ingredients in dietary supplements. The list is subject to change (check the provided link for current status).
- Norcoclaurine
- 1-(4-hydroxyphenyl)methyl-1
- 2
- 3
- 4-tetrahydroisoquinoline-6
- 7-diol
Higenamine tends to be dosed in similar levels as synephrine or ephedrine, meaning a dose of 20-30mg taken 2-3 times daily. There is currently no evidence to support this as an optimal dose.