Summary of Harpagophytum procumbens
Primary Information, Benefits, Effects, and Important Facts
Harpagophytum Procumbens (commonly called Devil's Claw) is a tuber vegetable that is used for combatting lower back pain as well as arthritis (both osteoarthritis and rheumatoid arthritis). It appears to have efficacy at this, and may take a few months to reach maximal efficacy (so it would be unlikely something like Aspirin, which acts fairly fast).
Human trials have been conducted on Devil's Claw and arthritis, and although there appear to be a large amount of trials conducted on it many are not sourced online or in Medline (instead mentioned vicariously through systemic reviews and meta-analysis' on the subject) and the power of these trials are limited, due to sample sizes and lack of control for the most part. That being said, at least two well controlled trials note that the efficacy of Devil's Claw is greater than placebo with one saying it is of similar potency to Vioxx (Rofecoxib, a COX2 inhibitor and antiinflammatory).
Not too much research into other effects of Devil's Claw, although one study suggests it has remarkable anticholesterase inhibitory potential with the potency on butrylcholinesterase (a cholinesterase enzyme found in the blood and liver) being greater than Galantamine.
There appears to be much discussion on safety of Devil's Claw, which may have stemmed from traditional users of Devil's Claw warning about excessive usage. In short term trials it appears to be well tolerated, with a lack of long term evidence. It is definitely possible that it may induce uterine contractions when taken orally, and due to this it should not be used by pregnant women.
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How to TakeMedical Disclaimer
Recommended dosage, active amounts, other details
Studies conducted on humans using Devil's Claw tend to use a brand called Doloteffin, where 6,000mg of Devil's Claw root is taken daily which totals 50mg Harpagoside (tends to be used as an indicator of efficacy). It was taken in three divided doses, with 2,000mg taken at each of the three major meals.
Benefits of Devil's Claw extract, as it pertains to arthritis and inflammation, may take upwards of 1-4 months to achieve maximal efficacy.
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects harpagophytum procumbens has on your body, and how strong these effects are.
|Grade||Level of Evidence [show legend]|
|Robust research conducted with repeated double-blind clinical trials|
|Multiple studies where at least two are double-blind and placebo controlled|
|Single double-blind study or multiple cohort studies|
|Uncontrolled or observational studies only|
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|Minor||- See study|
|Minor||Very High See all 3 studies|
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