GABA
Summary of GABA
Primary Information, Benefits, Effects, and Important Facts
GABA is the most potent depressive neuroamine in human brains. It regulates many of the depressive and sedative actions in brain tissue and is critical for relaxation.
GABA is a highly regulated compound in vivo (in living), and is able to balance itself out in body tissues due to a myriad of factors.
Due to these regulation factors, GABA as a supplement does not exert many depressive effects on its own. The human body is too adept at regulation, and orally ingested GABA cannot alter human physiology to much of a degree.
GABA, however, is a target for many other compounds that can act vicariously (in a multitude of ways) to increase GABA levels, which ultimately causes depressive effects.
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Things To Know & Note
Is a Form Of
Other Functions:
Primary Function:
Also Known As
Gamma-Aminobutyric Acid
Goes Well With
Nitric Oxide increasing agents
Caution Notice
Examine.com Medical DisclaimerGABA is a depressive neurotransmitter, but supplementation with GABA does not seem to exert depressive effects unless overdosed to an inadvisable level.
How to Take GABA
Recommended dosage, active amounts, other details
Supplemental GABA has been used in humans (for the purpose of enhancing growth hormone metabolism) in the dosage range of 3,000-5,000mg GABA. It is unsure if this is the optimal dosage.
Research Breakdown on GABA
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References
- ^ Petroff OA. GABA and glutamate in the human brain. Neuroscientist. (2002)
- ^ GABA in plasma and cerebrospinal fluid of different species. Effects of γ-acetylenic GABA, γ-vinyl GABA and sodium valproate.
- ^ Transport of GABA at the Blood-CSF Interface.
- ^ a b c d Al-Sarraf H. Transport of 14C-gamma-aminobutyric acid into brain, cerebrospinal fluid and choroid plexus in neonatal and adult rats. Brain Res Dev Brain Res. (2002)
- ^ Efflux of a suppressive neurotransmitter, GABA, across the blood–brain barrier.
- ^ Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals.
- ^ Shyamaladevi N, et al. Evidence that nitric oxide production increases gamma-amino butyric acid permeability of blood-brain barrier. Brain Res Bull. (2002)
- ^ Cavagnini F, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh). (1980)
- ^ Cavagnini F, et al. Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone. J Clin Endocrinol Metab. (1980)
- ^ a b Powers ME, et al. Growth hormone isoform responses to GABA ingestion at rest and after exercise. Med Sci Sports Exerc. (2008)
- ^ Nindl BC, et al. Growth hormone molecular heterogeneity and exercise. Exerc Sport Sci Rev. (2003)
- ^ De Palo EF, et al. Growth hormone isoforms, segments/fragments: does a link exist with multifunctionality. Clin Chim Acta. (2006)
