Supplementation in rats tend to use 200-400mg/kg of the gum or oleoresin, which leads to an estimated human dosage of:
2,200-4,400mg for a 150lb person
2,900-5,800mg for a 200lb person
3,600-7,300mg for a 250lb person
These are estimated human dosages based on the animal research, and it is not known if they are the optimal human doses or not.