Dong Quai
•Last Updated: September 28 2022
Angelica gigas is an herb used in traditional Korean medicine, usually by women. It is being studied for its potential anti-cancer and immune-boosting properties.
Dong Quai is most often used for
Last Updated: September 28 2022
Angelica gigas, also called Dang Gui, is an herb traditionally used in Korean medicine. The plants of the angelica family are used to improve gynecological health.
Though Angelica gigas is often seen as a female supplement, it is also used to improve cardiovascular and immune system health for both men and women.
Preliminary evidence suggests Angelica gigas supplementation may be able to affect hormone levels in a potent way. The herb is also being investigated for its anti-cancer effects, since it may be able to suppress the proliferation and migration of cancer cells. Further research is needed to confirm these effects.
Angelica gigas supplementation increases the level at which B cells reproduce. B cells produce antibodies, so this effect strengthens the immune system.
Angelica gigas is still being researched. It has promise for being used alongside chemotherapy, but more evidence is needed before it can be specifically recommended.
Note that Dong Quai is also known as:
- Dang Gui
- Korean Dang Gui
- Cham-Dang-Gui
- Angelica Gigas
Dong Quai should not be confused with:
- Angelica sinensis (Chinese Dang Gui)
- Angelica acutiloba (Japanese Dang Gui)
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3.^Joo SS, Park D, Shin S, Jeon JH, Kim TK, Choi YJ, Lee SH, Kim JS, Park SK, Hwang BY, Lee do I, Kim YBAnti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation modelsEnviron Toxicol Pharmacol.(2010 Sep)
4.^Zhao RJ, Koo BS, Kim GW, Jang EY, Lee JR, Kim MR, Kim SC, Kwon YK, Kim KJ, Huh TL, Kim DH, Shim I, Yang CHThe essential oil from Angelica gigas NAKAI suppresses nicotine sensitizationBiol Pharm Bull.(2005 Dec)
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7.^Ahn KS, Sim WS, Kim IHDecursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigasPlanta Med.(1996 Feb)
8.^Shin S, Joo SS, Park D, Jeon JH, Kim TK, Kim JS, Park SK, Hwang BY, Kim YBEthanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathwayJ Vet Sci.(2010 Mar)
9.^Kim EJ, Kwon J, Park SH, Park C, Seo YB, Shin HK, Kim HK, Lee KS, Choi SY, Ryu do H, Hwang GSMetabolite profiling of Angelica gigas from different geographical origins using 1H NMR and UPLC-MS analysesJ Agric Food Chem.(2011 Aug 24)
10.^Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway.()
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18.^HPLC Analysis and Extraction Methods of Decursin and Decursinol Angelate in Angelica gigas Roots.()
19.^Jiang C, Lee HJ, Li GX, Guo J, Malewicz B, Zhao Y, Lee EO, Lee HJ, Lee JH, Kim MS, Kim SH, Lu JPotent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancerCancer Res.(2006 Jan 1)
20.^Chang A, Kwak BY, Yi K, Kim JSThe effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled studyPhytother Res.(2012 Apr)
21.^Jo SK, Lee HJ, Kim SR, Kim JC, Bae CS, Jung U, Park HR, Jang JS, Kim SHAntiinflammatory activity of an herbal preparation (HemoHIM) in ratsPhytother Res.(2007 Jul)
22.^Kim JJ, Cho HW, Park HR, Jung U, Jo SK, Yee STPreventative Effect of an Herbal Preparation (HemoHIM) on Development of Airway Inflammation in Mice via Modulation of Th1/2 Cells DifferentiationPLoS One.(2013 Jul 2)
23.^Kim SH, Lee HJ, Kim JS, Moon C, Kim JC, Park HR, Jung U, Jang JS, Jo SKProtective effect of an herbal preparation (HemoHIM) on radiation-induced intestinal injury in miceJ Med Food.(2009 Dec)
24.^Song JS, Chae JW, Lee KR, Lee BH, Choi EJ, Ahn SH, Kwon KI, Bae MAPharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in ratsXenobiotica.(2011 Oct)
25.^Kim KM, Kim MJ, Kang JSAbsorption, distribution, metabolism, and excretion of decursin and decursinol angelate from Angelica gigas NakaiJ Microbiol Biotechnol.(2009 Dec)
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27.^Li L, Zhang J, Shaik AA, Zhang Y, Wang L, Xing C, Kim SH, Lü JQuantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLCPlanta Med.(2012 Feb)
28.^Park HS, Kim B, Oh JH, Kim YC, Lee YJFirst-pass metabolism of decursin, a bioactive compound of Angelica gigas, in ratsPlanta Med.(2012 Jun)
29.^Abd El-Aty AM, Shah SS, Kim BM, Choi JH, Cho HJ, Hee-Yi, Chang BJ, Shin HC, Lee KB, Shimoda M, Shim JHIn vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2D15, and 3A12 isoforms in canine hepatic microsomesArch Pharm Res.(2008 Nov)
31.^Chae JW, An JH, Kang W, Ma Jy, Kwon KIEffect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in ratsFood Chem Toxicol.(2012 Oct)
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33.^Li L, Du JK, Zou LY, Wu T, Lee YW, Kim YHDecursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPKEvid Based Complement Alternat Med.(2013)
34.^Li L, Li W, Jung SW, Lee YW, Kim YHProtective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymesBiosci Biotechnol Biochem.(2011)
35.^Choi SS, Han KJ, Lee JK, Lee HK, Han EJ, Kim DH, Suh HWAntinociceptive mechanisms of orally administered decursinol in the mouseLife Sci.(2003 Jun 13)
36.^Seo YJ, Kwon MS, Park SH, Sim YB, Choi SM, Huh GH, Lee JK, Suh HWThe analgesic effect of decursinolArch Pharm Res.(2009 Jun)
37.^Liu J, Beller DAberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-kappa B expression and binding to the IL-12 p40 promoterJ Immunol.(2002 Jul 1)
38.^Hwang JT, Kim SH, Hur HJ, Kim HJ, Park JH, Sung MJ, Yang HJ, Ryu SY, Kim YS, Cha MR, Kim MS, Kwon DYDecursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat dietPhytother Res.(2012 May)
39.^Choi KO, Lee I, Paik SY, Kim DE, Lim JD, Kang WS, Ko SUltrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effectJ Med Food.(2012 Oct)
40.^Han SB, Kim YH, Lee CW, Park SM, Lee HY, Ahn KS, Kim IH, Kim HMCharacteristic immunostimulation by angelan isolated from Angelica gigas NakaiImmunopharmacology.(1998 Jul)
41.^Jeon YJ, Han SB, Ahn KS, Kim HMDifferential activation of murine macrophages by angelan and LPSImmunopharmacology.(2000 Sep)
42.^Jeon YJ, Han SB, Ahn KS, Kim HMActivation of NF-kappaB/Rel in angelan-stimulated macrophagesImmunopharmacology.(1999 Jun)
43.^Jeon YJ, Kim HMExperimental evidences and signal transduction pathways involved in the activation of NF-kappa B/Rel by angelan in murine macrophagesInt Immunopharmacol.(2001 Jul)
44.^Jeon YJ, Han SB, Lee SH, Kim HC, Ahn KS, Kim HMActivation of mitogen-activated protein kinase pathways by angelan in murine macrophagesInt Immunopharmacol.(2001 Feb)
45.^Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SKEvaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cellsJ Ethnopharmacol.(2002 Nov)
46.^Kim JH, Jeong JH, Jeon ST, Kim H, Ock J, Suk K, Kim SI, Song KS, Lee WHDecursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophagesMol Pharmacol.(2006 Jun)
47.^Gorbachev AV, Fairchild RLCD4+ T cells regulate CD8+ T cell-mediated cutaneous immune responses by restricting effector T cell development through a Fas ligand-dependent mechanismJ Immunol.(2004 Feb 15)
48.^Kitagaki H, Ono N, Hayakawa K, Kitazawa T, Watanabe K, Shiohara TRepeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profileJ Immunol.(1997 Sep 1)
49.^Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC/Nga mice in specific-pathogen-free condition.()
50.^Regulation of macrophage inflammatory protein-2 gene expression in response to 2,4-dinitrofluorobenzene in RAW 264.7 cells.()
51.^Zhang Y, Shaik AA, Xing C, Chai Y, Li L, Zhang J, Zhang W, Kim SH, Lü J, Jiang CA synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivoInvest New Drugs.(2012 Oct)
52.^Han SB, Lee CW, Kang MR, Yoon YD, Kang JS, Lee KH, Yoon WK, Lee K, Park SK, Kim HMPectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functionsCancer Lett.(2006 Nov 18)
53.^Jang J, Jeong SJ, Kwon HY, Jung JH, Sohn EJ, Lee HJ, Kim JH, Kim SH, Kim JH, Kim SHDecursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma CellsEvid Based Complement Alternat Med.(2013)
54.^Yim D, Singh RP, Agarwal C, Lee S, Chi H, Agarwal RA novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cellsCancer Res.(2005 Feb 1)
55.^Ikezoe T, Yang Y, Taguchi H, Koeffler HPJNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA)Br J Cancer.(2004 May 17)
56.^Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCα.()
57.^Woo SM, Choi YK, Cho SG, Park S, Ko SGA New Herbal Formula, KSG-002, Suppresses Breast Cancer Growth and Metastasis by Targeting NF- κ B-Dependent TNF α Production in MacrophagesEvid Based Complement Alternat Med.(2013)
58.^Kim EY, Rhyu MRSynergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii and Angelica gigasJ Ethnopharmacol.(2010 May 31)
59.^Kim EY, Rhyu MRSynergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii and Angelica gigasJ Ethnopharmacol.(2010 Aug 9)
60.^Mahat B, Chae JW, Baek IH, Song GY, Song JS, Cho SK, Kwon KIPhysicochemical characterization and toxicity of decursin and their derivatives from Angelica gigasBiol Pharm Bull.(2012)
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