Danshen

•Last Updated: November 17 2022

Salvia militorrhiza (Danshen) is a Traditional Chinese Medicine used for circulatory and heart health; it appears to be somewhat effective at this claim and is one of the best selling Chinese Medicines for heart health.

dosage

Danshen is most often used for

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Kamal Patel, MPH, MBA

Last Updated: November 17 2022

summary
Dosage information
Research breakdown
References

Summary

Salvia militorrhiza, or Danshen, is a traditional Asian herbal medication for circulatory ailments. It has shown efficacy in treating various markers of heart health, and is typically seen as a very heart healthy herb.

Danshen works through a few primary ingredients, which all work synergistically on various parameters of heart and circulatory health.

It is the largest herbal market in China, and is commonly sold as dripping pills (to be absorbed under the tongue) or as oral tablets. Both are effective, but the dripping pills appear to provide more of the active ingredients.

What else is Danshen known as?

Note that Danshen is also known as:

Danshen
Salvia Militorrhiza

Danshen should not be confused with:

Salvia divinorum (street drug)
Codonopsis Pilosula (Dangshen)

Dosage information

The Fufang Danshen Dripping pill is most commonly used as 30 pills spread over 3 times a day (10 each) taken either sublingually or orally.

Fufang Danshen tablets are taken 3 times a day, with 3 taken each time.

The standard therapeutic dose of Danshen is 6.56mg / kg bodyweight

Research Breakdown

1

Sources and composition

2

Pharmacology

2.1

Absorption

2.2

Enzymatic Interactions

3

Contributions of individual ingredients to its clinical efficacy

4

Clinical uses

5

Adverse interactions and Toxicity

References

1.^Zhou L, Zuo Z, Chow MSDanshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical useJ Clin Pharmacol.(2005 Dec)

2.^Chemical Characteristics of Salvia miltiorrhiza (Danshen) Collected from Different Locations in China.()

3.^Feng BS, Li SRStudies on the chemical components of Dan-shen (Salvia miltiorrhiza Bunge) (author's transl)Yao Xue Xue Bao.(1980 Aug)

4.^Chen X, Li W, Xia W, Luo H, Liu XA comparative study on the chemical components of Salvia miltiorrhiza Bge. collected from Zhongjiang of Sichuan and from other habitatsZhongguo Zhong Yao Za Zhi.(1997 Sep)

5.^Preparation and Enhanced Oral Bioavailability of Cryptotanshinone-Loaded Solid Lipid Nanoparticles.()

6.^Zhang Y, Akao T, Nakamura N, Duan CL, Hattori M, Yang XW, Liu JXExtremely low bioavailability of magnesium lithospermate B, an active component from Salvia miltiorrhiza, in ratPlanta Med.(2004 Feb)

7.^Zhao FQ, Zheng NX, Sato H, Adachi I, Horikoshi IPharmacokinetics of a Chinese traditional medicine, danshensu (3,4-dihydroxyphenyllactic acid), in rabbits using high-performance liquid chromatographyBiol Pharm Bull.(1997 Mar)

8.^Luo X, Bi K, Zhou S, Wei Q, Zhang RDetermination of Danshensu, a major active compound of Radix Salvia miltiorrhiza in dog plasma by HPLC with fluorescence detectionBiomed Chromatogr.(2001 Dec)

9.^Study of the determination and pharmacokinetics of Compound Danshen Dripping Pills in human serum by column switching liquid chromatography electrospray ion trap mass spectrometry.()

10.^Qualitative and quantitative analysis of Compound Danshen Dripping Pills by CS-HPLC.()

11.^Qiu F, Wang G, Zhao Y, Sun H, Mao G, A J, Sun JEffect of danshen extract on pharmacokinetics of theophylline in healthy volunteersBr J Clin Pharmacol.(2008 Feb)

12.^Sarkar MA, Hunt C, Guzelian PS, Karnes HTCharacterization of human liver cytochromes P-450 involved in theophylline metabolismDrug Metab Dispos.(1992 Jan-Feb)

13.^Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes.()

14.^Zhao BL, Jiang W, Zhao Y, Hou JW, Xin WJScavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injuryBiochem Mol Biol Int.(1996 May)

15.^O K, Lynn EG, Vazhappilly R, Au-Yeung KK, Zhu DY, Siow YLMagnesium tanshinoate B (MTB) inhibits low density lipoprotein oxidationLife Sci.(2001 Jan 12)

16.^Li M, Zhao C, Wong RN, Goto S, Wang Z, Liao FInhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid BClin Hemorheol Microcirc.(2004)

17.^Au-Yeung KK, Zhu DY, O K, Siow YLInhibition of stress-activated protein kinase in the ischemic/reperfused heart: role of magnesium tanshinoate B in preventing apoptosisBiochem Pharmacol.(2001 Aug 15)

18.^Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats.()

19.^Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells.()

20.^Niu XL, Ichimori K, Yang X, Hirota Y, Hoshiai K, Li M, Nakazawa HTanshinone II-A inhibits low density lipoprotein oxidation in vitroFree Radic Res.(2000 Sep)

21.^Is danshen (Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials.()

22.^Chan TYInteraction between warfarin and danshen (Salvia miltiorrhiza)Ann Pharmacother.(2001 Apr)

23.^Gupta D, Jalali M, Wells A, Dasgupta ADrug-herb interactions: unexpected suppression of free Danshen concentrations by salicylateJ Clin Lab Anal.(2002)

Primary Use

Cardiovascular Health