Last Updated: September 28 2022

Cyanidin is one of the six Anthocyanin subsets, and its glucoside Cyanidin-3-Glucoside (C3G) has been garnering attention for its ability to decrease blood glucose levels, and its ability to not hinder muscle protein synthesis at the same time (downstream of AMPK activation).


Cyanidins are a sub-category of the dark pigments found in blue-black fruits and berries as well as some purple vegetables known as Anthocyanins. Cyanidins can be seen as the most pharmaceutically effective anthocyanin subcomponent as they seem to have the greatest uptake rate, the least decay, and the most clinical significance out of all anthocyanins.

It has various effects in cells, most of which can be described as being anti-diabetic and possibly slightly benefit other parameters associated with 'metabolic syndrome' (anti-inflammatory, anti-oxidant, etc.)

It does have some problems with absorption though, so the results you see in in vitro (in laboratory) studies may not apply to when it is consumed. Its bioavailability (percent absorbed) is a concern, and human intervention studies important for this reason.

What else is Cyanidin known as?
Note that Cyanidin is also known as:
  • Cyanidin-3-Glucoside
  • C3G
  • Cyanidin-3-Rutinoside
Cyanidin should not be confused with:
  • Anthocyanins
  • Delphinidin
Dosage information

Benefits have been seen with blood sugar reductions in the range of 150mg/kg bodyweight, a dose well above what is achieved through foods.

It is possible long-term benefits may be seen with a lower dose of cyanidin compounds through foods, due to the many correlations of plant intake and health; however, causation has not been given to cyanidins as of yet.

Additionally, it may be possible to increase bioavailability and thus lower the needed dose by inhibiting P450 enzymes (similar to curcumin being potentiated by piperine). However, this is for the most part currently an untested hypothesis.

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      3.^Galvano F, La Fauci L, Vitaglione P, Fogliano V, Vanella L, Felgines CBioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosidesAnn Ist Super Sanita.(2007)
      4.^Vitaglione P, Donnarumma G, Napolitano A, Galvano F, Gallo A, Scalfi L, Fogliano VProtocatechuic acid is the major human metabolite of cyanidin-glucosidesJ Nutr.(2007 Sep)
      5.^McDougall GJ, Fyffe S, Dobson P, Stewart DAnthocyanins from red cabbage--stability to simulated gastrointestinal digestionPhytochemistry.(2007 May)
      10.^Passamonti S, Vrhovsek U, Vanzo A, Mattivi FThe stomach as a site for anthocyanins absorption from foodFEBS Lett.(2003 Jun 5)
      12.^Tsuda T, Horio F, Osawa TAbsorption and metabolism of cyanidin 3-O-beta-D-glucoside in ratsFEBS Lett.(1999 Apr 23)
      14.^Talavéra S, Felgines C, Texier O, Besson C, Manach C, Lamaison JL, Rémésy CAnthocyanins are efficiently absorbed from the small intestine in ratsJ Nutr.(2004 Sep)
      15.^Grace MH, Ribnicky DM, Kuhn P, Poulev A, Logendra S, Yousef GG, Raskin I, Lila MAHypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium AitonPhytomedicine.(2009 May)
      17.^Kurilich AC, Clevidence BA, Britz SJ, Simon PW, Novotny JAPlasma and urine responses are lower for acylated vs nonacylated anthocyanins from raw and cooked purple carrotsJ Agric Food Chem.(2005 Aug 10)
      18.^Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun XPharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 daysJ Clin Pharmacol.(2005 Oct)
      19.^Felgines C, Talavera S, Texier O, Gil-Izquierdo A, Lamaison JL, Remesy CBlackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humansJ Agric Food Chem.(2005 Oct 5)
      20.^Frank T, Sonntag S, Strass G, Bitsch I, Bitsch R, Netzel MUrinary pharmacokinetics of cyanidin glycosides in healthy young men following consumption of elderberry juiceInt J Clin Pharmacol Res.(2005)
      23.^Nielsen IL, Dragsted LO, Ravn-Haren G, Freese R, Rasmussen SEAbsorption and excretion of black currant anthocyanins in humans and watanabe heritable hyperlipidemic rabbitsJ Agric Food Chem.(2003 Apr 23)
      24.^McGhie TK, Ainge GD, Barnett LE, Cooney JM, Jensen DJAnthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and ratsJ Agric Food Chem.(2003 Jul 30)
      25.^Frank T, Netzel M, Strass G, Bitsch R, Bitsch IBioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juiceCan J Physiol Pharmacol.(2003 May)
      27.^Bitsch I, Janssen M, Netzel M, Strass G, Frank TBioavailability of anthocyanidin-3-glycosides following consumption of elderberry extract and blackcurrant juiceInt J Clin Pharmacol Ther.(2004 May)
      28.^Harada K, Kano M, Takayanagi T, Yamakawa O, Ishikawa FAbsorption of acylated anthocyanins in rats and humans after ingesting an extract of Ipomoea batatas purple sweet potato tuberBiosci Biotechnol Biochem.(2004 Jul)
      30.^Kay CD, Mazza G, Holub BJ, Wang JAnthocyanin metabolites in human urine and serumBr J Nutr.(2004 Jun)
      34.^Tian Q, Giusti MM, Stoner GD, Schwartz SJUrinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolitesJ Agric Food Chem.(2006 Feb 22)
      38.^Sadilova E, Carle R, Stintzing FCThermal degradation of anthocyanins and its impact on color and in vitro antioxidant capacityMol Nutr Food Res.(2007 Dec)
      39.^Tsuda T, Ueno Y, Aoki H, Koda T, Horio F, Takahashi N, Kawada T, Osawa TAnthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytesBiochem Biophys Res Commun.(2004 Mar 26)
      42.^Kousteni SFoxO1: a molecule for all seasonsJ Bone Miner Res.(2011 May)
      43.^Southgate RJ, Neill B, Prelovsek O, El-Osta A, Kamei Y, Miura S, Ezaki O, McLoughlin TJ, Zhang W, Unterman TG, Febbraio MAFOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscleJ Biol Chem.(2007 Jul 20)
      44.^Wei X, Wang D, Yang Y, Xia M, Li D, Li G, Zhu Y, Xiao Y, Ling WCyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activityJ Sci Food Agric.(2011 Apr)
      45.^Scazzocchio B, Varì R, Filesi C, D'Archivio M, Santangelo C, Giovannini C, Iacovelli A, Silecchia G, Li Volti G, Galvano F, Masella RCyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytesDiabetes.(2011 Sep)
      47.^Chen BL, Ma YD, Meng RS, Xiong ZJ, Wang HN, Zeng JY, Liu C, Dong YGActivation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitroActa Pharmacol Sin.(2010 Jul)
      50.^Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, Tanaka A, Nishiumi S, Fukuda I, Ashida H, Horio F, Tsuda TCyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic miceBiochem Pharmacol.(2007 Dec 3)
      52.^Ding M, Feng R, Wang SY, Bowman L, Lu Y, Qian Y, Castranova V, Jiang BH, Shi XCyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activityJ Biol Chem.(2006 Jun 23)
      53.^Katsube N, Iwashita K, Tsushida T, Yamaki K, Kobori MInduction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyaninsJ Agric Food Chem.(2003 Jan 1)
      56.^Lala G, Malik M, Zhao C, He J, Kwon Y, Giusti MM, Magnuson BAAnthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in ratsNutr Cancer.(2006)
      58.^Matsumoto H, Ito K, Yonekura K, Tsuda T, Ichiyanagi T, Hirayama M, Konishi TEnhanced absorption of anthocyanins after oral administration of phytic acid in rats and humansJ Agric Food Chem.(2007 Mar 21)