Summary of Creatinol O-Phosphate
Primary Information, Benefits, Effects, and Important Facts
Creatinol O-Phosphate (COP) is a synthetic analogue of creatine that was created as a cardioprotective drug, and it appears to be helpful against arrythmia and aid the integrity of cardiac tissue following injections of up to three grams. Via this method of administration and dosage, it appears to be safe as well as effective.
A lack of information exists on COP oral ingestion and whether the benefits translate from oral to injections. Additionally, all research appears to be a few decades old and has since just ceased for unknown reasons; a weird thing for such a promising compound (unless another cardioprotective agent was deemed safer and more effective, making injections of COP for clinical usage not needed to be researched anymore).
Due to the lack of pharmacokinetic data, it is hard to ascertain the benefits associated with COP ingestion. If absorbed, it will be cardioprotective and safe. Optimal dosing regimen is not known at this time due to no bioavailability data.
For all intents and purposes, COP supplementation should be viewed as completely different as creatine supplementation. Even after COP loses the phosphorus group, it metabolizes into creatinol and not creatine.
Tired of misinformation? Get unbiased info on supplements.
At Examine.com, our incentives line up with yours — getting unbiased information. It’s why we don’t sell any advertising or supplements.
If you’re tired of wasting time and money on supplements that don’t work, our free Supplement Mini-Course will teach you about what works, what's a waste, and what to look out for when buying supplements.
Join the over 200,000 people who have gone through this course (saving themselves time, money, and stress).
Things To Know & Note
Primary Function:
Also Known As
COP, Creatinolphosphate, Aplodan
Do Not Confuse With
Caution Notice
Examine.com Medical DisclaimerHow to Take Creatinol O-Phosphate
Recommended dosage, active amounts, other details
Past studies used injections of up to 3g daily. There is currently no bioavailability data on how much is absorbed, but if it is 100% then this is the dose where benefits have been noted in humans.
Research Breakdown on Creatinol O-Phosphate
Click on any below to expand the corresponding section. Click on to collapse it.
Click here to fully expand all sections or here to fully collapse them.
References
- ^ a b c Godfraind T, Saleh MM. Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart. Arzneimittelforschung. (1984)
- ^ Marzo A, Ghirardi P. Pharmacological and toxicological properties of creatinol O-phosphate. A review. Arzneimittelforschung. (1979)
- ^ Godfraind T, Sturbois X. The prevention by creatinol O-phosphate of myocardial lesions evoked by isoprenaline. Arch Int Pharmacodyn Ther. (1979)
- ^ a b c Ferrini R, Miragoli G. Protective effect of creatinol O-phosphate (COP) on some experimental arrhythmias in vitro and in vivo. Arzneimittelforschung. (1979)
- ^ Godfraind T, Sturbois X. An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat. Arzneimittelforschung. (1979)
- ^ Knippel M, Bana G, Pusterla GL. Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction. Arzneimittelforschung. (1979)
- ^ Di Maio F, et al. Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial. Arzneimittelforschung. (1979)
- ^ Cadel A, et al. Antiarrhythmic effectiveness of creatinol O-phosphate in man. Arzneimittelforschung. (1979)
- ^ Botti G, Bonatti V. Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects. Arzneimittelforschung. (1979)
- ^ Melloni GF, et al. Acute clinical tolerance of creatinol O-phosphate. Arzneimittelforschung. (1979)