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Chrysin

A flavonoid compound found in bee pollen and propolis. Can boost testosterone when injected into testicles; otherwise isn't absorbed at all. Unless better absorption arises, chrysin remains a pretty interesting colon cancer preventative agent that does not boost testosterone.

Our evidence-based analysis on chrysin features 24 unique references to scientific papers.

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Examine.com Team
Last Updated:

Summary of Chrysin

Primary Information, Benefits, Effects, and Important Facts

Chrysin is a bioflavonoid compound found in high levels in propolis and in honey.

Chrysin is most well known for being a testosterone boosting plant compound, although this seems to be a misleading claim. While it has very good mechanisms of action that would lead to the conclusion that it could boost testosterone (as in, it sensitizes the testicles to produce more testosterone and inhibits the conversion of testosterone to estrogen) these both occur at significantly higher oral doses than are seen with oral supplementation. Chrysin appears to be poorly absorbed, and even then it is readily metabolized resulting in insufficient levels in the blood and testes to exert these beneficial effects.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Due to the poor bioavailability, the standard supplemental doses of chrysin (400-3,000mg) appear to be pretty much ineffective. Although enhancing absorption can theoretically aid in chryin's effects, this has not yet been demonstrated and thus supplementation of chrysin cannot be recommended for systemic purposes.

A supplemental dose of 400mg chrysin should be sufficient for intestinal related issues.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects chrysin has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c - - See study
Has failed to increase testosterone levels in one study.

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Things to Note

Is a Form Of

Primary Function:

Also Known As

Propolis, Honey extract, Passiflora caerulea Linn

Goes Well With

  • COX2 inhibitors (for the purposes of StAR upregulation)

  • StAR inducers like D-Aspartic Acid (as it potentiates the effects of cAMP induction)

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Click here to see all 24 references.