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Research Breakdown on Black Pepper
Black Pepper (Piper Nigrum) is a common spice and herb used historically for various diseases related to gastrointesinal disorder and dental or oral dysfunction. It is most commonly known in the supplemental realm for its piperine content, but also contains pellitorine, guineensine, pipnoohine, trichostachine, and piperonal.curcumin bioavailability by 2000%. It affects metabolism by both intestinal absorption as well as downregulating or inhibiting phase II detoxification enzymes and the glucuronidation process in the liver. It may also contribute to increase absorption by slowing intestinal transit rate and thus prolonging the time said compounds are exposed to the potential uptake. In higher doses, it can induce gastric acid secretion possibly via agonism of gastric histamine H2 receptors.: Evidence of carcinogenicity]. These effects, however, were not noted with oral ingestion despite rodent hypersensitivity to piperine. It is generally recognized as safe for human consumption.
- Rao VR, et al. Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. Nat Prod Res. (2011)
- Shoba G, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. (1998)
- Han HK. The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin Drug Metab Toxicol. (2011)
- Bajad S, et al. Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med. (2001)
- Ononiwu IM, Ibeneme CE, Ebong OO. Effects of piperine on gastric acid secretion in albino rats. Afr J Med Med Sci. (2002)
- Black pepper [piper nigrum.
- Lack of Adverse Influence of Black Pepper, Its Oleoresin and Piperine in the Weanling Rat.
- Piyachaturawat P, Glinsukon T, Toskulkao C. Acute and subacute toxicity of piperine in mice, rats and hamsters. Toxicol Lett. (1983)
- Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. (2007)