Beta-Alanine

Last Updated: September 21, 2023

Beta-alanine is a building block of carnosine, a molecule that helps buffer acid in muscles. Beta-alanine supplementation improves performance during high-intensity exercise lasting from 1 to 10 minutes. Carnosine also has antioxidant effects and may be beneficial for aging and neurological conditions.

Beta-Alanine is most often used for.



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1.

Sources and Structure

1.1

Sources

Carnosine, the active metabolite of beta-alanine, is most abundant in skeletal muscle. Muscle levels of carnosine depend on the metabolic acidosis the animal is subjected to. Deep-sea species of fish, in particular, are thought to maintain high carnosine levels to combat the state of metabolic acidosis induced by low oxygen levels in deep waters.[7] The highest carnosine levels are seen in horses, racing dogs, and the Balaenoptera acutorostrata whale. Farm-raised animals, being less active, would have lower levels of carnosine than wild animals.[8]

Carnosine and beta-alanine being most abundant in skeletal muscle, they are most abundant in meat products, such as:

  • Beef: 1,500 μg[9] or 1,745-1,961 μg[10] per gram of meat
  • Pork: 2,439±13 μg[10] per gram of meat
  • Poultry: 666±9 μg per gram of meat (with thrice as much anserine as carnosine)[10]
  • Chicken broth[9]
  • Fish[11]

Meat is the main dietary source of carnosine and beta-alanine. Levels of both are correlated with the amount of metabolic activity the animal underwent during its life, and are higher in landbound animals than in poultry.

1.2

Synthesis De Novo

Beta-alanine is converted into the dipeptide carnosine (beta-alanyl-L-histidine) via the addition of a histidine (L-histidine) amino acid group. Carnosine synthase, the enzyme responsible for this transformation, was later identified as ATP-Grasp Domain-containing protein 1.[12] ATPGD1 is expressed highly in skeletal muscle and to a lesser extent in the brain.[13] Carnosine is abundant in skeletal muscle, but can also be found in the brain and the cardiac muscle. Its foremost role is to maintain the acid base equilibrium (buffering H+ ions), but it can also sensitize contractile muscles to calcium[14] and is neuroprotective (a potential treatment for autism[15]), anti-aging,[16] antioxidant,[17] and protective against glycation.[18]

Carnosine is synthesized from beta-alanine via the ATPGD1 enzyme, which is locally expressed in skeletal muscle and the brain.

Carnosine cannot enter muscle cells to a significant extent,[19] but its two substrates can. The synthesis or intake of beta-alanine, not histidine, is the rate-limiting step in carnosine synthesis in vivo.[20] Beta-alanine is synthesized in the liver[21] then transported to muscle cells, where carnosine is in turn synthesized (and stored, in type II more than in type I muscle fibers).

Since ATPGD1 is expressed highly in skeletal muscle, and since the availability of beta-alanine is the limiting factor in carnosine synthesis, beta-alanine supplementation is highly effective at increasing muscle carnosine stores.[22][23] Beta-alanine increases muscle carnosine stores to a greater degree than the same oral dose of carnosine (with the difference becoming nonsignificant with increasing carnosine dose). This may be due to a higher percentage of ingested beta-alanine being devoted to skeletal muscle,[24] as compared to ingested carnosine. Ingested carnosine cannot enter muscles cells to a significant extent,[19] but it can be hydrolyzed in vivo into its two substrates, beta-alanine and histidine, which can enter muscles cells and there serve to synthesize carnosine.

Beta-alanine is created in the liver and excreted into the serum, where it can be taken up by tissues expressing the ATPGD1 enzyme to create carnosine. Since beta-alanine availability is the limiting factor in carnosine synthesis, beta-alanine supplementation increases carnosine synthesis in these tissues.

Ingested carnosine is hydrolyzed into its two substrates, beta-alanine and histidine, via two different carnosinase enzymes, CN1 and CN2.[25] The CN1 protein is specific to carnosine and found mostly in the serum, while CN1 mRNA is expressed mostly in the brain and liver. It should be noted that interspecies differences exist: While CN1 can be found in the aforementioned areas in humans (with a lack of circulating carnosine as the result), it concentrates in the kidneys of rodents.[26] CN2, a non-specific dipeptidase present in the cytosol of cells, is fairly prominent but only hydrolyzes carnosine at a pH of 9.5 (which suggests that it regulates excess carnosine).[25]

Carnosine is hydrolyzed into its two substrates by carnosinase enzymes, one specific (expressed in the liver and brain) and one non-specific (which may regulate excess levels of carnosine).

1.3

Carnosine Status (Deficiency, Surplus)

Deficiency states, redeemable through supplementation, are possible with some pseudo-vitamin compounds, such as creatine or carnitine (L-carnitine). Beta-alanine does not appear to be similar in this regard. Dietary histidine deficiency, on the other hand, depresses serum and muscle levels of both beta-alanine and carnosine.[27] Levels are restored when histidine is supplemented.[28]

Beta-alanine and carnosine do not have pseudo-vitamin status. Any state of deficiency related to either could also be called a general “protein deficiency” associated with the essential amino acid histidine. It can be avoided by consuming more protein.

Carnosine levels are lower in vegetarians (as compared to omnivores) and decrease with age, but the physiological consequences are uncertain.

One study divided omnivorous subjects between an omnivorous diet group (control) and a vegetarian diet group. The omnivorous diet group experienced a nonsignificant 11% increase in carnosine storage; the vegetarian diet group experienced a nonsignificant 9% decrease; the difference between the two groups reached significance.[29] The vegetarian group expressed less carnosine synthase mRNA,[29] which tends to be upregulated in response to both carnosine and beta-alanine ingestion.[13]

A decrease in carnosine storage of up to 35% has been observed in aging mice,[30] but the physiological consequences are again uncertain. Still, it has been hypothesized that a diet rich in carnosine might help fight aging and its associated pathologies.[31][32]

Beta-alanine or carnosine supplementation would probably be a good idea for vegetarians and vegans.

One study noted that baseline carnosine in elite rowers and baseline carnosine in a previously studied untrained control were similar.[33] Other studies, however, found that trained individuals could store more carnosine in their muscles than sedentary individuals[34] — twice the amount, for experienced bodybuilders.[35]

These effects, however, may not be due to the act of training. Although an increase in muscle carnosine during short term resistance training has been reported,[36] most studies do not show acute changes in carnosine levels with training alone.[37][38] The variations in muscle carnosine content between non-supplemented populations may be due to differences in food intake, to long-term adaptations (possibly in hepatic beta-alanine synthesis), or, in the case of some bodybuilders, to the confounding effects of testosterone injections.[39]

Higher carnosine levels have been observed in people with a history of athleticism. This is not systematic, however, and may reflect a difference in dietary carnosine (quantity of meat consumed) rather than in training load.

2.

Pharmacology

2.1

Supplementation

Carnosine (beta-alanyl-L-histidine) is a dipeptide composed of beta-alanine and histidine (L-histidine). Intracellular carnosine levels are determined primarily by the availability of extracellular beta-alanine;[20] this primary determinant is overruled only by an outright histidine deficiency.[45] For that reason, histidine has seldom been used to enhance intracellular carnosine stores.[28]

As a rule, the availability of beta-alanine is the limiting factor in carnosine production. Only in the case of an actual histidine deficiency does supplementing histidine increase carnosine stores.

In the liver, carnosinase enzymes can metabolize ingested carnosine into histidine and beta-alanine. In such a way, carnosine supplementation can provide beta-alanine to overcome the rate limit of carnosine synthesis in muscle tissues. Moreover, it appears that carnosine itself can be absorbed: A human study found between 1.2% and 14% of ingested carnosine (1, 2, or 4 g) excreted intact in the urine. In the same study, the ingestion of 2 g of beta-alanine and 2 g of histidine did not influence carnosine levels in the urine.[46]

It is thought that carnosine can be absorbed from the intestinal tract[47] via proton-coupled peptide transporters PEPT1 and PEPT2,[48][49] despite not being found in the blood (probably because CN1, the plasma carnosinase enzyme, metabolizes free carnosine rapidly).[46] A later study analyzing carnosine kinetics also noted that both supplemental and dietary carnosine failed to elicit a detectable serum spike, although anserine and urinary carnosine increased.[9]

While elevated carnosine levels can be found in the serum of animals, humans seem to rapidly hydrolyze ingested carnosine. Consequently, supplementing with beta-alanine seems preferable to supplementing with carnosine.

2.2

Distribution

At equal doses, supplemental beta-alanine appears more effective than supplemental carnosine at increasing muscle carnosine, with all the associated ergogenic benefits.[24]

A study of daily beta-alanine supplementation noted increases in the carnosine content of the gastrocnemius muscle (mostly type II fibers): 8.1±11.5% after 2 weeks at 1.6 g (increasing to 35.5±13.3% after 8 weeks) and 9.7±10.8% after 2 weeks at 3.2 g (increasing to 44.5±12.5% after 2 more weeks at 3.2 g and 4 weeks at 1.6 g).

In the tibialis muscle (mostly type I fibers), these increases reached 11.8±7.4% after 2 weeks at 1.6 g (increasing to 30.3±14.8 after 8 weeks) and 17.4±9.6% after 2 weeks at 3.2 g (increasing to 21.9±14.4% after 2 more weeks at 3.2 g and 4 weeks at 1.6 g).

The differences between the two muscles might be due to the lower baseline levels of beta-alanine in type I fibers.

The same study found that beta-alanine had no influence on muscle creatine.[50]

Beta-alanine supplementation can increase muscle carnosine in as little as two weeks, with no effect on muscle creatine.

One 4-week study had two groups of seven subjects undergo a unilateral training program. The first group received 6.4 g of beta-alanine daily; the second group, serving as control, received a placebo. In the beta-alanine group, muscle carnosine increased equally in both the trained and untrained leg of each subject. In the control group, no increase of muscle carnosine was noted. This suggests that muscle contractions do not increase muscle carnosine.[51]

Muscular contractions do not seem to increase muscle carnosine.

In a 5-week study of healthy subjects supplementing with 4.8 g of beta-alanine daily, muscle carnosine increased more when beta-alanine was taken with meals (+64%) than when it was taken between meals (+41%).[52]

Supplemental beta-alanine increases muscle carnosine to a greater extent when taken with food.

2.3

Elimination

One 4-week study compared two groups of healthy young athletes, both supplementing daily with beta-alanine: One group took 1.6 g for 8 weeks; the other took 3.2 g for 4 weeks, then 1.6 g for 4 more weeks. The increase in muscle carnosine was greater in the 3.2-g group than in the 1.6-g group. This difference persisted after the 4 weeks with the same 1.6-g dose, and still slightly after the subsequent 8-week washout.[50]

The increase in muscle carnosine due to beta-alanine supplementation appears to last longer than 8 weeks after said supplementation has ceased. This tells us little on the washout period of beta-alanine itself.

3.

Longevity and Aging

Carnosine, the product that beta-alanine forms to buffer H+ ions, appears to exert rudimentary anti-aging properties. It has been hypothesized to act like resveratrol, due to their respective mechanisms being linked to exercise.[16] Currently, most known mechanisms of carnosine are related to protein metabolism.

A decline in muscle carnosine of up to 45% has been noted during the aging process of senescence-accelerated mice (SAMP8).[30]

Carnosine depletion appears to be associated with aging. Increasing carnosine stores may attenuate the aging process.

3.1

Mechanisms

Carnosine can reduce the rate of cellular aging in cultured fibroblasts.[53][54] This anti-aging effect may be due to carnosine’s ability to reduce the rate of telomere shortening, as was noted at 20 mM in cultured human fibroblasts.[55] Alternatively, it may be due to carnosine’s ability to suppress post-synthetic errors in protein metabolism, since cellular accumulation of altered proteins (damaged protein byproducts in the cytosol) and the subsequent proteotoxic stress are strongly associated with the aging process.[56][57]

The causative role of toxic proteins in the aging process is strengthened by studies linking reduced aging rates with reduced protein synthesis. A reduction in protein synthesis means a reduction in metabolic byproducts such as protein carbonyls. Also, studies on Caenorhabditis elegans nematodes suggest that, since fewer new proteins are being made, fewer will be misfolded. This will free up chaperone proteins to sequester and help to clear out already existing proteins that may have been damaged through oxidation or glycation.[58][59] A link between reduced aging rate and reduced protein synthesis has also been observed in methionine-deficient mice.[60][61]

Carnosine’s ability to reduce protein alteration may derive from its being an antioxidant, a chelator of toxic metal ions, an anti-glycating agent, and an aldehyde/carbonyl binder.[62] More precisely, carnosine has shown suppressive effects on protein alteration induced by Reactive Oxygen Species (ROS),[63] Reactive Nitrogen Species (RNS),[64] glycating agents such as Advanced Glycation End products (AGEs, which are intimately linked with the aging process[65]),[18][66] and aldehydes such as malondialdehyde (MDA),[67] methylglyoxal (MG),[68] and hydroxynonenal.[69] These latter findings appear to be relevant in vivo: Carnosine-aldehyde adducts have been detected in the urine, indicating they are formed in the body,[70][71] while a carnosine-phosphatidylcholine adduct has been detected in living human leg tissue.[72]

Additionally, carnosine has been shown to induce vimentin,[73] a readily glycated protein that acts in a sacrificial manner to reduce the reactivity of protein carbonyls and aldehydes.[74] Carnosine might also suppress mRNA translation initiation.[75]

Carnosine appears to have general protective (antioxidant) effects on a variety of proteins in cells. This may prevent the accumulation of toxic (oxidized) proteins in the body. Carnosine may also act in a sacrificial manner to excrete some modified protein carbonyls from the body.

Not only may carnosine protect cells from toxic proteins, it may also reduce the formation of these proteins by stimulating proteolysis (the breakdown of proteins).[76][77][78] This action may be secondary to the upregulation of Heat-Shock Proteins (HSPs are proteins produced by cells placed under stressful conditions) via carnosine-Zinc complexes known as polaprezinc.[79][80][81]

Carnosine might also act as a central point for different metabolic pathways that reduce the formation of protein carbonyls and aldehydes.

3.2

Interventions

Currently, carnosine has shown anti-aging effects in Drosophila flies[82][83] and senescence-accelerated mice.[84][85] The first mice study noted that a 50% survival rate was increased by 20% in animals treated with carnosine. This increase in median lifespan was replicated in the second study, which used an oral dose of carnosine (100 mg/kg/day, which correlates to a little over 8 mg/kg/day in humans, so about 725 mg/day for a 200-lb subject). Both mice studies only noted an increase in median lifespan, with no change in maximum lifespan.

Carnosine appears to be more effective as an anti-aging agent than an equimolar combination of beta-alanine and histidine.[85] Interestingly, since Creatine supplementation can also increase muscle carnosine (though to a lesser extent than beta-alanine), it may indirectly increase lifespan.[30]

Carnosine may be more effective than beta-alanine as an anti-aging agent. In flies, it has been shown to extend lifespan; in mice, it appears to extend median lifespan without significantly influencing maximal lifespan.

4.

Neurology

4.1

Mechanisms

Beta-alanine moderates many neurological actions through competitive inhibition of taurine (beta-alanine and taurine compete for the same transporter to get into the brain).[86][87] This is why cells incubated with beta-analine see their taurine stores depleted, either in part[88] or in full.[89]

Beta-alanine appears to act via glycine and GABAA receptors (like taurine[90]) with comparable efficacy to glycine and GABA themselves.[91] On the other hand, beta-alanine has been noted to act as an antagonist of the system A transporter, used by cells in the brain to take up glycine.[92]

Beta-alanine may have effects similar to the inhibitory neurotransmitters glycine and GABA, while at the same time competing with these molecules. The overall consequences are unclear at this time.

Via carnosine, beta-alanine may also exert antioxidant effects. Carnosine can support the structure of the antioxidant enzyme Cu/Zn SuperOxide Dismutase (SOD).[42] This mechanism has been noted in vivo in rats[93] and may explain increased SOD activity in humans.[94] The basic antioxidant properties of carnosine would support SOD’s own antioxidant activity, similarly to how carnitine (L-carnitine) can stabilize SOD to enhance its actions.[95]

Carnosine has also been implicated in reducing oxidative damage to lipids[84][96] and proteins.[97] Carnosine could therefore reduce the aggregation of oxydized proteins in neural tissues.[98][99] Possibly via these actions, carnosine has shown benefit to motor functions in people with Parkinson’s disease[94] and might aid in Alzheimer’s disease.[97]

Beta-alanine, via carnosine, may be a neurological antioxidant.

4.2

Neurotransmitters

Beta-alanine, when fed to mice over a month, did not appear to significantly influence serotonin or adrenaline levels in the cortex or the hypothalamus. However, it reduced levels of serotonin’s main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in the hypothalamus.[87] A significant increase in brain carnosine and Brain-Derived Neurotrophic Factor (BDNF) levels were also noted.[87]

In the nucleus accumbens, dopamine levels appear to increase as beta-alanine concentrations increase from 0.1 to 10 mM. Beta-alanine would exert this effect through the glycine receptor, not unlike taurine, alcohol, or glycine itself.[100]

4.3

Interventions

In a mice study comparing the effects of taurine and beta-alanine (22.5 mmol/kg), taurine was more effective at reducing periods of immobility in a Forced Swim Test (suggesting a greater anti-depressive action), while beta-alanine significantly improved performance on an Elevated Plus Maze (suggesting a greater anxiolytic action).[87]

An 8-week human study associated beta-alanine to a non-significant trend for better mood relative to placebo, with no difference between the 1.6-g and 3.2-g groups.[50]

There is a lack of evidence on mood effects, but beta-alanine may possess anxiolytic (anxiety-reducing) properties.

One pilot study of 36 patients with Parkinson’s disease paired basic therapy (personalized L-DOPA or dopaminergic medication) with 1.5 g of preformed carnosine (beta-alanyl-L-histidine) for 30 days. The carnosine group improved by 32–53% on the motor parameters of the Unified Parkinson’s Disease Rating Scale — including hand tremors, muscle stiffness, and mobility issues. MAO-B activity was unaffected. The activity of Cu/Zn SOD increased by 26%, which may have caused the decrease in serum protein carbonyls noted.[94]

4.4

Chronic Fatigue

As a predictor of Chronic Fatigue Syndrome (CFS), an excess of beta-alanine in the urine has been deemed second only to the presence of amino-hydroxy-N-methyl-pyrrolidine (CFSUM1).[101] In further analysis, urinary beta-alanine was the best predictor of the CFS symptoms of dizziness, hyperesthesia (photophobia included), myalgia and muscle cramps, as well as abdominal pain and gastric reflux.[102] However, a later study of a CFS group found that only a subgroup exhibited elevated urinary beta-alanine levels; the CFS group as a whole was not, in this regard, significantly different than control.[103]

More than forty years earlier, CFS symptoms (notably persistent lethargy, somnolence, and altered pain response) had already been noted in the rare disorder of hyper-beta-alanemia — an inborn error of metabolism that results in elevated beta-alanine levels in the serum.[104]

Some correlative evidence suggests that beta-alanine might play a role in chronic fatigue, but no conclusion can be drawn at this point in time.

5.

Exercise and Performance

5.1

Mechanisms

Out of the multiple mechanisms of systemic buffering (including proteins and amino acids, bicarbonate, and phosphates), carnosine contributes to intracellular buffering due to the imidazole structure of its histidine residue.[8] Large amounts of histidine dipeptides can be stored in cells with no apparent adverse effects. Theses stores explain why the synthesis or intake of beta-alanine, not histidine, is the rate-limiting step in the production of carnosine. The benefits of beta-alanine are highly associated with how much beta-alanine and carnosine (two buffering agents) are present in a muscle cell prior to contraction.[105]

Due to this buffering, beta-alanine can reduce acidosis without influencing oxygen uptake.[106] Although lactate (lactic acid) does not appear to inhibit muscular contraction per se, it is correlated. This may be due to an accumulation of H+ ions eventually inhibiting muscle contraction and glycolysis.[107] Many studies have noted that buffering acidity in vivo leads, via either direct or indirect mechanisms, to increases in performance in short-term high-intensity exercise.[108]

5.2

Neural Function

Beta-alanine appears to reduce the perception of fatigue and delay volitional exhaustion in women,[109] older individuals (55-92 years old),[110] and collegiate American-football players. The latter study noted a discord between fatigue as measured by subjective ratings (the reduction reached significance) and fatigue as measured by a Wingate anaerobic test (the reduction merely trended toward significance).[111]

Beta-alanine and creatine appear to have additive effects in regard to reducing fatigue.[112]

Beta-alanine may reduce the perception of fatigue during exercise to near-exhaustion, and at least one study on elderly people suggests an improvement in neural function, as well as a lower risk of falling.

5.3

Power Output

With regard to beta-alanine supplementation, a 30-day study (4.8 g/day) noted a power increase in resistance-trained men,[113] while a 10-week study (6.4 g/day) found no increase in one-rep max (1RM) or isometric strength in isolation.[37] A previous 4-week study (4.8 g/day) had noted an improvement in the muscular endurance of sprinters during repeated maximal contractions, with no improvement in power during a 400-m sprint test.[22]

When power-related studies are subjected to meta-analysis,[114] the effect size they reveal, though larger than placebo, fails to reach statistical significance. When only studies on effort lasting 60 seconds or less are pooled (which excludes events like rowing[33]) the effect size is not different from placebo.

Creatine’s efficacy at improving peak power output may be slightly enhanced by beta-alanine.[115]

Improvements in acute power output have been noted but are much less reliable than the effects on longer-duration exercise. While beta-alanine does not appear to significantly increase acute power output, it may enhance the accrual of power over time, secondary to enhanced exercise volume.

5.4

Anaerobic Exercise

In a 7-week study on elite rowers (training 9.5 times a week on average) covering 2,000 m, five daily doses of beta-alanine (1 g every other hour, 5 g total) led to better performance (2.7±4.8 s) relative to placebo (1.7±6.8 s). Muscle carnosine levels both pre- and post-supplementation were highly correlated with improvements, which mostly occurred in the 500–1,500-m range (the portion of the 2,000-m distance that saw the athletes row the slowest).[33]

Most studies show less positive results, however. In a more recent 28-day study on elite rowers also covering 2,000 m, the benefits of a daily dose of beta-alanine (80 mg/kg/day) failed to reach statistical significance, though barely.[116] In a 6-week study on athletic women, four 1.5-g doses of beta-alanine (6 g/day) failed to increase VO2 max more than placebo (dextrose), though it trended to enhance performance (and an increase in lean mass was noted).[117] In an 8-week study on collegiate wrestlers and American-football players, a daily dose of beta-alanine (4 g) led to improvements in all tests (especially the 300-yd shuttle run and the 90° flexed-arm hang), but these improvements also failed to reach statistical significance. [118] Finally, in a 4-week study, beta-alanine (4 g/day for 1 week, followed by 6 g/day for 3 weeks) failed to improve sprint performance, though the testing protocol (maximal sprints on non-motorized treadmill) might have skewed the results.[119]

Beta-alanine seems to benefit all athletes (male or female, novice or advanced), though seldom to the point of reaching statistical significance.

Beta-alanine shows the most promise in two kinds of exercises: exercises that stress intracellular acidosis (exercises lasting more than 30 s, as a rule, since failure from H+ ions is minimal under that time[120]) and short high-intensity exercises (such as sprinting, rowing, and weight-lifting — not necessarily at one-rep max).[22][121] [122][123] In studies using resistance training as a means of measuring performance, an increase in workload volume is sometimes observed.[111]

According to a meta-analysis, the benefits associated with beta-alanine tend to occur with activities lasting 60–240 s. Over that range, benefits decrease. Under that range, benefits are not significant.[114] This meta-analysis also pooled the collective benefit at 2.85% greater than placebo when the median dose was 179 g (total, so about 6 g/day for one month, or 3 g/day for two months), suggesting a minor if statistically significant benefit.[114] The same conclusion can be reached from a 10-week study on elite swimmers: 4 weeks of beta-alanine at 4.8 g/day was associated with a 1.3±1% improvement in performance parameters, but after 6 more weeks at 3.2 g/day statistical significance had been lost.[124]

This meta-analysis also noted that a third of the studies (5 out of 15) acknowledged an element of financial support from a supplement company.[23][125][112][126][127]

Beta-alanine appears to reliably improve a variety of exercise parameters, but mostly for efforts lasting 60–240 s. Above that range, benefits decrease. Under that range, benefits are not significant.

6.

Interactions with Body Composition

6.1

Interactions with Exercise

One 8-week study supplemented beta-alanine (4 g/day) to collegiate wrestlers and American-football players. While the football players saw no significant increase in total mass, the beta-alanine group gained more lean mass (2.1±3.6 lb = 953±1,633 g) than the placebo group (1.1±2.3 lb = 499±1,043 g) and gained less fat mass (0.88%) than the placebo group (0.1%).

Among the wrestlers, both the beta-alanine group and the placebo group lost fat, but the beta-alanine group saw an increase in lean mass (1.1±4.3 lb = 499±1,950 g), while the placebo group saw a decrease (0.98±2.6 lb = 445±1,179 g). Consequently, the beta-alanine group lost less total mass (0.43±4.6 lb = 195±2,087 g) than the placebo group (3.2±4.9 lb = 1,452±2,223 g).[118] This was a poster presentation; the full text cannot be found online.

In a 6-week study on athletic women, the beta-alanine group (6 g of beta-alanine and 60 g of glucose per day) saw an increase in lean mass, while the control group (66 g of glucose per day) did not. Fat mass remained unchanged. This study used a High-Intensity Interval Training (HIIT) protocol, and dietary recall suggested no significant differences in diet.[117]

Similarly, in a 3-week study on 46 healthy men, four 1.5-g doses of beta-alanine (6 g/day) coupled with four 15-g doses of dextrose (60 g/day) led to a significant increase in lean mass, from 67.6±8.9 kg at the beginning of the study to 68.6±8.6 kg at the end of the study. Fat mass remained unchanged. This study used cycle ergometers and an HIIT protocol.[125]

Beta-alanine appears to contribute to lean mass gains, through mechanisms currently unknown. The notion that these benefits are dependent on exercise cannot be refuted, since all three relevant studies paired beta-alanine supplementation with an exercise regimen.

7.

Interactions with Hormones

7.1

Testosterone

30 days of beta-alanine supplementation at 4.8 g/day, which was able to increase workout capacity, did so without influencing the testosterone response to exercise in healthy males.[113] This lack of effect has also has been observed with preformed carnosine.[128]

7.2

Cortisol

30 days of beta-alanine supplementation at 4.8 g/day, which was able to increase workout capacity, did so without influencing the cortisol response to exercise in healthy males.[113]

7.3

Growth Hormone

30 days of beta-alanine supplementation at 4.8 g/day, which was able to increase workout capacity, did so without influencing the growth hormone response to exercise in healthy males.[113]

8.

Nutrient-Nutrient Interactions

8.1

Taurine

Both Taurine and beta-alanine are acidic with an amine in the beta position. In that respect, they share a similar structure with the neurotransmitter GABA. Taurine and beta-alanine share the same transporter (SLC6a6), so competition may occur. In experimental conditions, beta-alanine can induce a transient taurine deficiency.[129][130][131][132] However, none of the human studies using supplemental beta-alanine (up to 6.4 g/day) mentioned side-effects suggestive of a taurine deficiency (such as an increase in muscle cramps).

Theoretically, taurine and beta-alanine are antagonistic, but the practical relevance of their interactions is not known at this time.

8.2

Creatine

Creatine and beta-alanine both enjoy an extensive body of evidence for their efficacy in trained athletes. For that reason, they are often seen as sister supplements, and several trials have been conducted with their combination.

One 10-week study in collegiate football players reported in its abstract that, compared to creatine alone, a combination of creatine and beta-alanine “appeared” to lead to greater lean mass gain and fat mass loss. The article itself, however, only reported body composition numbers for the placebo group and the combination group, not for the creatine group.[115]

Published the same year, a 4-week study supplemented untrained men with creatine (5.25 g), beta-alanine (1.6 g), and dextrose (34 g) four times a day for 6 days then twice a day for 22 days. An increase in performance at the neuromuscular fatigue threshold was noted, but was almost solely due to beta-alanine, with no additive effects from creatine. In isolation, creatine failed to outperform placebo.[126]

In a subsequent 4-week study on women doing aerobic exercise and using the same supplementation protocol, beta-alanine in isolation also improved performance at the neuromuscular fatigue threshold, while the combination of beta-alaine and creatine showed additive benefits on parameters of cardiopulmonary fitness (VO2 max, lactate and ventilatory thresholds, time to exhaustion). On average, creatine improved the ventilatory threshold more, beta-alanine improved the lactate threshold more, and the combination slightly benefited both (while still failing to influence VO2 max significantly).[109]

There seems to be little synergism between beta-alanine and creatine with regard to performance.

8.3

Sodium Bicarbonate

Sodium bicarbonate (baking soda) has been investigated for its ability to improve performance via an H+-buffering mechanism similar to beta-alanine’s.

One 4-week study on men doing HIIT found that both beta-alanine (6.4 g/day) and sodium bicarbonate (0.3 g/kg/day: two thirds with breakfast; one third 2 hours before testing) significantly improved performance in isolation. Their combination appears to have additive effects, but those failed to reach statistical significance.[133] This additive effect has failed to be noted elsewhere (3.1+/-1.8% with sodium bicarbonate, 3.3+/-3.0% with the combination).[134]

Both beta-alanine and sodium bicarbonate are somewhat effective at the same thing, but it's unclear if they're additive when used together.

9.

Safety, Toxicity, and Side-Effects

9.1

Parasthesia

Beta-alanine supplementation can cause paresthesia, a potentially uncomfortable but ultimately harmless tingling of the skin that commonly affects the face but has also been reported in the abdomen, chest, and extremities.

Paresthesia typically occurs when too great a dose of beta-alanine is taken acutely. It can be avoided by taking extended-release formulations[135][50] or smaller doses (800 mg on average, or 10 mg/kg in sedentary individuals) at least 3 hours apart (based on the time to peak serum levels, the compound half-life, and the time to return to baseline).[105] One study used 1-g doses every other hour (5 g/day).[33]

9.2

Taurine Deficiency

Due to taurine and beta-alanine sharing the same transporter, a taurine deficiency can be experimentally induced by beta-alanine overfeeding. One study on rats showed that this deficiency may lead to a greater susceptibility to alcohol-induced liver fat buildup (something taurine normally protects against[136]) by coupling a large dose of alcohol (36% of caloric intake) with a fairly small dose of beta-alanine (3% of drinking water).[129] This dose of beta-alanine has also been noted to induce cardiac effects in mice, including remodelling[137] and lipid peroxidation.[132]

In animals, this 3% intake of beta-alanine in water may reduce circulating levels of taurine by 50%[130] to 77%[131] and cardiac levels of taurine by 16.6% to 22.7%.[132]

Prolonged cellular exposure to beta-alanine appears to reliably induce taurine deficiency. In animal studies, cellular taurine can be reduced by up to 77% with continual administration of beta-alanine via the drinking water.

None of the human studies indexed on Examine.com (with beta-alanine doses ranging from 2.6 to 6.4 g/day) suggests a resulting taurine deficiency, but this parameter has not been assesed directly.

Taurine deficiency is probably not a practical concern with conservative beta-alanine supplementation (with breaks, to let cells accumulate taurine). Excessive usage of beta-alanine over a long period of time has not been studied in humans, however, so the possibility that it could lead to taurine deficiency cannot be ruled out. Severe muscle cramps can be a symptom of taurine deficiency and could serve as an indicator.

References
1.^Pedro Perim, Felipe Miguel Marticorena, Felipe Ribeiro, Gabriel Barreto, Nathan Gobbi, Chad Kerksick, Eimear Dolan, Bryan SaundersCan the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?Front Nutr.(2019 Aug 27)
2.^Trexler ET, Smith-Ryan AE, Stout JR, Hoffman JR, Wilborn CD, Sale C, Kreider RB, Jäger R, Earnest CP, Bannock L, Campbell B, Kalman D, Ziegenfuss TN, Antonio JInternational society of sports nutrition position stand: Beta-AlanineJ Int Soc Sports Nutr.(2015 Jul 15)
3.^Alyssa N Varanoske, Jay R Hoffman, David D Church, Nicholas A Coker, Kayla M Baker, Sarah J Dodd, Roger C Harris, Leonardo P Oliveira, Virgil L Dawson, Ran Wang, David H Fukuda, Jeffrey R StoutComparison of sustained-release and rapid-release β-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocolAmino Acids.(2019 Jan)
4.^David D Church, Jay R Hoffman, Alyssa N Varanoske, Ran Wang, Kayla M Baker, Michael B La Monica, Kyle S Beyer, Sarah J Dodd, Leonardo P Oliveira, Roger C Harris, David H Fukuda, Jeffrey R StoutComparison of Two β-Alanine Dosing Protocols on Muscle Carnosine ElevationsJ Am Coll Nutr.(Nov-Dec 2017)
6.^Stegen S, Blancquaert L, Everaert I, Bex T, Taes Y, Calders P, Achten E, Derave WMeal and beta-alanine coingestion enhances muscle carnosine loading.Med Sci Sports Exerc.(2013-Aug)
7.^Miyaji K, Nagao K, Bannai M, Asakawa H, Kohyama K, Ohtsu D, Terasawa F, Ito S, Iwao H, Ohtani N, Ohta MCharacteristic metabolism of free amino acids in cetacean plasma: cluster analysis and comparison with micePLoS One.(2010 Nov 2)
9.^Yeum KJ, Orioli M, Regazzoni L, Carini M, Rasmussen H, Russell RM, Aldini GProfiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humansAmino Acids.(2010 Mar)
10.^Gil-Agustí M1, Esteve-Romero J, Carda-Broch SAnserine and carnosine determination in meat samples by pure micellar liquid chromatographyJ Chromatogr A.(2008 May 2)
11.^Abe H, Dobson GP, Hoeger U, Parkhouse WSRole of histidine-related compounds to intracellular buffering in fish skeletal muscleAm J Physiol.(1985 Oct)
12.^Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen EMolecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)J Biol Chem.(2010 Mar 26)
13.^Miyaji T, Sato M, Maemura H, Takahata Y, Morimatsu FExpression profiles of carnosine synthesis-related genes in mice after ingestion of carnosine or ß-alanineJ Int Soc Sports Nutr.(2012 Apr 17)
15.^Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen JDouble-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disordersJ Child Neurol.(2002 Nov)
16.^Hipkiss AROn the enigma of carnosine’s anti-ageing actionsExp Gerontol.(2009 Apr)
17.^Boldyrev AADoes carnosine possess direct antioxidant activityInt J Biochem.(1993 Aug)
22.^Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten Ebeta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprintersJ Appl Physiol (1985).(2007 Nov)
23.^Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JAInfluence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacityAmino Acids.(2007 Feb)
24.^Everaert I, Stegen S, Vanheel B, Taes Y, Derave WEffect of beta-alanine and carnosine supplementation on muscle contractility in miceMed Sci Sports Exerc.(2012 Aug 14)
25.^Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova TSequence identification and characterization of human carnosinase and a closely related non-specific dipeptidaseJ Biol Chem.(2003 Feb 21)
26.^Sauerhöfer S, Yuan G, Braun GS, Deinzer M, Neumaier M, Gretz N, Floege J, Kriz W, van der Woude F, Moeller MJL-carnosine, a substrate of carnosinase-1, influences glucose metabolismDiabetes.(2007 Oct)
28.^Tamaki N, Tsunemori F, Wakabayashi M, Hama TEffect of histidine-free and -excess diets on anserine and carnosine contents in rat gastrocnemius muscleJ Nutr Sci Vitaminol (Tokyo).(1977)
29.^Baguet A, Everaert I, De Naeyer H, Reyngoudt H, Stegen S, Beeckman S, Achten E, Vanhee L, Volkaert A, Petrovic M, Taes Y, Derave WEffects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacityEur J Appl Physiol.(2011 Oct)
33.^Baguet A, Bourgois J, Vanhee L, Achten E, Derave WImportant role of muscle carnosine in rowing performanceJ Appl Physiol.(2010 Oct)
34.^Parkhouse WS, McKenzie DC, Hochachka PW, Ovalle WKBuffering capacity of deproteinized human vastus lateralis muscleJ Appl Physiol (1985).(1985 Jan)
35.^Tallon MJ, Harris RC, Boobis LH, Fallowfield JL, Wise JAThe carnosine content of vastus lateralis is elevated in resistance-trained bodybuildersJ Strength Cond Res.(2005 Nov)
36.^Suzuki Y, Ito O, Takahashi H, Takamatus KThe effect of sprint training on skeletal muscle Carnosine in humansInt J Sport Health Sci.(2004)
39.^Peñafiel R, Ruzafa C, Monserrat F, Cremades AGender-related differences in carnosine, anserine and lysine content of murine skeletal muscleAmino Acids.(2004 Feb)
40.^Aruoma OI, Laughton MJ, Halliwell BCarnosine, homocarnosine and anserine: could they act as antioxidants in vivo?Biochem J.(1989 Dec 15)
47.^Hama T, Tamaki N, Miyamoto F, Kita M, Tsunemori FIntestinal absorption of beta-alanine, anserine and carnosine in ratsJ Nutr Sci Vitaminol (Tokyo).(1976)
48.^Kamal MA, Jiang H, Hu Y, Keep RF, Smith DEInfluence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null miceAm J Physiol Regul Integr Comp Physiol.(2009 Apr)
49.^Geissler S, Zwarg M, Knütter I, Markwardt F, Brandsch MThe bioactive dipeptide anserine is transported by human proton-coupled peptide transportersFEBS J.(2010 Feb)
50.^Stellingwerff T, Anwander H, Egger A, Buehler T, Kreis R, Decombaz J, Boesch CEffect of two β-alanine dosing protocols on muscle carnosine synthesis and washoutAmino Acids.(2012 Jun)
51.^Kendrick IP, Kim HJ, Harris RC, Kim CK, Dang VH, Lam TQ, Bui TT, Wise JAThe effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and -II human skeletal muscle fibresEur J Appl Physiol.(2009 May)
52.^Stegen S, Blancquaert L, Everaert I, Bex T, Taes Y, Calders P, Achten E, Derave WMeal and beta-alanine coingestion enhances muscle carnosine loadingMed Sci Sports Exerc.(2013 Aug)
55.^Shao L, Li QH, Tan ZL-carnosine reduces telomere damage and shortening rate in cultured normal fibroblastsBiochem Biophys Res Commun.(2004 Nov 12)
57.^Rosenberger RFSenescence and the accumulation of abnormal proteinsMutat Res.(1991 Mar-Nov)
58.^Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon CLifespan extension by conditions that inhibit translation in Caenorhabditis elegansAging Cell.(2007 Feb)
59.^Hipkiss AROn why decreasing protein synthesis can increase lifespanMech Ageing Dev.(2007 May-Jun)
60.^Naudí A, Caro P, Jové M, Gómez J, Boada J, Ayala V, Portero-Otín M, Barja G, Pamplona RMethionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brainRejuvenation Res.(2007 Dec)
62.^Hipkiss ARCarnosine, a protective, anti-ageing peptideInt J Biochem Cell Biol.(1998 Aug)
63.^Kohen R, Yamamoto Y, Cundy KC, Ames BNAntioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brainProc Natl Acad Sci U S A.(1988 May)
64.^Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli EProtective effect of carnosine during nitrosative stress in astroglial cell culturesNeurochem Res.(2005 Jun-Jul)
65.^Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlassara HReduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expressionAm J Pathol.(2007 Jun)
67.^Hipkiss AR, Preston JE, Himswoth DT, Worthington VC, Abbot NJProtective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cellsNeurosci Lett.(1997 Dec 5)
68.^Hipkiss AR, Chana HCarnosine protects proteins against methylglyoxal-mediated modificationsBiochem Biophys Res Commun.(1998 Jul 9)
69.^Aldini G, Carini M, Beretta G, Bradamante S, Facino RMCarnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?Biochem Biophys Res Commun.(2002 Dec)
73.^Ikeda D, Wada S, Yoneda C, Abe H, Watabe SCarnosine stimulates vimentin expression in cultured rat fibroblastsCell Struct Funct.(1999 Apr)
74.^Kueper T, Grune T, Prahl S, Lenz H, Welge V, Biernoth T, Vogt Y, Muhr GM, Gaemlich A, Jung T, Boemke G, Elsässer HP, Wittern KP, Wenck H, Stäb F, Blatt TVimentin is the specific target in skin glycation. Structural prerequisites, functional consequences, and role in skin agingJ Biol Chem.(2007 Aug 10)
76.^Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles PA, Abbott NJPluripotent protective effects of carnosine, a naturally occurring dipeptideAnn N Y Acad Sci.(1998 Nov 20)
78.^Bonner AB, Swann ME, Marway JS, Heap LC, Preedy VRLysosomal and nonlysosomal protease activities of the brain in response to ethanol feedingAlcohol.(1995 Nov-Dec)
79.^Odashima M, Otaka M, Jin M, Konishi N, Sato T, Kato S, Matsuhashi T, Nakamura C, Watanabe SInduction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosineDig Dis Sci.(2002 Dec)
80.^Odashima M, Otaka M, Jin M, Wada I, Horikawa Y, Matsuhashi T, Ohba R, Hatakeyama N, Oyake J, Watanabe SZinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activationLife Sci.(2006 Nov 10)
81.^Ohkawara T, Nishihira J, Nagashima R, Takeda H, Asaka MPolaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteinsWorld J Gastroenterol.(2006 Oct 14)
82.^Yuneva AO, Kramarenko GG, Vetreshchak TV, Gallant S, Boldyrev AAEffect of carnosine on Drosophila melanogaster lifespanBull Exp Biol Med.(2002 Jun)
83.^Stvolinsky S, Antipin M, Meguro K, Sato T, Abe H, Boldyrev AEffect of carnosine and its Trolox-modified derivatives on life span of Drosophila melanogasterRejuvenation Res.(2010 Aug)
84.^Yuneva MO, Bulygina ER, Gallant SC, Kramarenko GG, Stvolinsky SL, Boldyrev AAEffect of Carnosine on Age-Induced Changes in Senescence-Accelerated MiceJ Anti-Aging Med.(1999)
85.^Gallant S, Semyonova M, Yuneva MCarnosine as a potential anti-senescence drugBiochemistry (Mosc).(2000 Jul)
88.^Jong CJ, Azuma J, Schaffer SWRole of mitochondrial permeability transition in taurine deficiency-induced apoptosisExp Clin Cardiol.(2011 Winter)
89.^Jong CJ, Ito T, Mozaffari M, Azuma J, Schaffer SEffect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine contentJ Biomed Sci.(2010 Aug 24)
93.^Stvolinskii SL, Fedorova TN, Yuneva MO, Boldyrev AAProtective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivoBull Exp Biol Med.(2003 Feb)
94.^Boldyrev A, Fedorova T, Stepanova M, Dobrotvorskaya I, Kozlova E, Boldanova N, Bagyeva G, Ivanova-Smolenskaya I, Illarioshkin SCarnosine {corrected} increases efficiency of DOPA therapy of Parkinson’s disease: a pilot studyRejuvenation Res.(2008 Aug)
96.^Dobrota D, Fedorova T, Stvolinsky S, Babusikova E, Likavcanova K, Drgova A, Strapkova A, Boldyrev ACarnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effectNeurochem Res.(2005 Oct)
99.^Seidler NW, Yeargans GS, Morgan TGCarnosine disaggregates glycated alpha-crystallin: an in vitro studyArch Biochem Biophys.(2004 Jul 1)
100.^Ericson M, Clarke RB, Chau P, Adermark L, Söderpalm BBeta-alanine elevates dopamine levels in the rat nucleus accumbens: antagonism by strychnineAmino Acids.(2010 Apr)
101.^McGregor NR, Dunstan RH, Zerbes M, Butt HL, Roberts TK, Klineberg IJPreliminary determination of a molecular basis of chronic fatigue syndromeBiochem Mol Med.(1996 Apr)
102.^McGregor NR, Dunstan RH, Zerbes M, Butt HL, Roberts TK, Klineberg IJPreliminary determination of the association between symptom expression and urinary metabolites in subjects with chronic fatigue syndromeBiochem Mol Med.(1996 Jun)
103.^Hannestad U, Theodorsson E, Evengård BBeta-alanine and gamma-aminobutyric acid in chronic fatigue syndromeClin Chim Acta.(2007 Feb)
105.^Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JAThe absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralisAmino Acids.(2006 May)
107.^Fitts RHCellular mechanisms of muscle fatiguePhysiol Rev.(1994 Jan)
108.^Artioli GG, Gualano B, Smith A, Stout J, Lancha AH JrRole of beta-alanine supplementation on muscle carnosine and exercise performanceMed Sci Sports Exerc.(2010 Jun)
109.^Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy JEffects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in womenAmino Acids.(2007)
110.^Stout JR, Graves BS, Smith AE, Hartman MJ, Cramer JT, Beck TW, Harris RCThe effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 years): a double-blind randomized studyJ Int Soc Sports Nutr.(2008 Nov 7)
111.^Hoffman JR, Ratamess NA, Faigenbaum AD, Ross R, Kang J, Stout JR, Wise JAShort-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football playersNutr Res.(2008 Jan)
113.^Hoffman J, Ratamess NA, Ross R, Kang J, Magrelli J, Neese K, Faigenbaum AD, Wise JABeta-alanine and the hormonal response to exerciseInt J Sports Med.(2008 Dec)
114.^Hobson RM, Saunders B, Ball G, Harris RC, Sale CEffects of β-alanine supplementation on exercise performance: a meta-analysisAmino Acids.(2012 Jul)
115.^Hoffman J1, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout JEffect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletesInt J Sport Nutr Exerc Metab.(2006 Aug)
116.^Ducker KJ, Dawson B, Wallman KEEffect of beta-alanine supplementation on 2,000-m rowing-ergometer performanceInt J Sport Nutr Exerc Metab.(2012 Dec 7)
119.^Sweeney KM, Wright GA, Glenn Brice A, Doberstein STThe effect of beta-alanine supplementation on power performance during repeated sprint activityJ Strength Cond Res.(2010 Jan)
122.^Bishop D, Edge J, Davis C, Goodman CInduced metabolic alkalosis affects muscle metabolism and repeated-sprint abilityMed Sci Sports Exerc.(2004 May)
124.^Chung W, Shaw G, Anderson ME, Pyne DB, Saunders PU, Bishop DJ, Burke LMEffect of 10-week beta-alanine supplementation on competition and training performance in elite swimmersNutrients.(2012 Oct 9)
125.^Smith AE, Walter AA, Graef JL, Kendall KL, Moon JR, Lockwood CM, Fukuda DH, Beck TW, Cramer JT, Stout JREffects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trialJ Int Soc Sports Nutr.(2009 Feb 11)
128.^Goto K, Maemura H, Takamatsu K, Ishii NHormonal responses to resistance exercise after ingestion of carnosine and anserineJ Strength Cond Res.(2011 Feb)
129.^Kerai MD, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JAThe effect of taurine depletion by beta-alanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in ratsAlcohol Alcohol.(2001 Jan-Feb)
130.^Dawson R Jr, Biasetti M, Messina S, Dominy JThe cytoprotective role of taurine in exercise-induced muscle injuryAmino Acids.(2002 Jun)
131.^Pansani MC, Azevedo PS, Rafacho BP, Minicucci MF, Chiuso-Minicucci F, Zorzella-Pezavento SG, Marchini JS, Padovan GJ, Fernandes AA, Matsubara BB, Matsubara LS, Zornoff LA, Paiva SAAtrophic cardiac remodeling induced by taurine deficiency in Wistar ratsPLoS One.(2012)
132.^Parildar H, Dogru-Abbasoglu S, Mehmetçik G, Ozdemirler G, Koçak-Toker N, Uysal MLipid peroxidation potential and antioxidants in the heart tissue of beta-alanine- or taurine-treated old ratsJ Nutr Sci Vitaminol (Tokyo).(2008 Feb)
133.^Sale C, Saunders B, Hudson S, Wise JA, Harris RC, Sunderland CDEffect of β-alanine plus sodium bicarbonate on high-intensity cycling capacityMed Sci Sports Exerc.(2011 Oct)
134.^Bellinger PM, Howe ST, Shing CM, Fell JWEffect of combined β-alanine and sodium bicarbonate supplementation on cycling performanceMed Sci Sports Exerc.(2012 Aug)
137.^Pansani MC, Azevedo PS, Rafacho BP, Minicucci MF, Chiuso-Minicucci F, Zorzella-Pezavento SG, Marchini JS, Padovan GJ, Fernandes AA, Matsubara BB, Matsubara LS, Zornoff LA, Paiva SAAtrophic cardiac remodeling induced by taurine deficiency in Wistar ratsPLoS One.(2012)