Last Updated: March 7 2023

One of the bioflavonoids, apigenin appears to be catered towards reducing anxiety and causing sedation. Found in chamomile tea, alcoholic beverages, and Bacopa Monnieri, apigenin is unstable by itself yet stable when consumed via foods and herbs.

Apigenin is most often used for


Apigenin is a bioflavonoid compound (specifically a flavone) that is found in a wide variety of plants and herbs. It is very abundant in chamomile tea, and exerts anxiety-reducing effects when consumed in these high doses. At even higher doses, it may be sedative.

Apigenin is also a very potent anti-cancer compound. It beneficially protects against a wide variety of cancers with high selectivity for cancer cells as opposed to non-cancerous cells. It also has a very high safety threshold, and active (anti-cancer) doses can be gained through consuming a vegetable and fruit rich diet.

What else is Apigenin known as?
Note that Apigenin is also known as:
  • biapigenin (a dimer found in nature)
  • 4' 5 7-Trihydroxyflavone
Apigenin should not be confused with:
  • Genistein
Dosage information

For general health and well-being, doses found in multiple servings of fruits and vegetables is adequate.

For anxiolytic effects, doses in the range of 2.4-8.1 mg/kg of bodyweight may be effective without sedation, and higher doses may induce sedation in addition to reductions in anxiety. This dose is derived from a study in mice and is post-conversion.

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2.^Shukla S, Gupta SApigenin: a promising molecule for cancer preventionPharm Res.(2010 Jun)
3.^Birt DF, Hendrich S, Wang WDietary agents in cancer prevention: flavonoids and isoflavonoidsPharmacol Ther.(2001 May-Jun)
5.^Bevilacqua L, Buiarelli F, Coccioli F, Jasionowska RIdentification of compounds in wine by HPLC-tandem mass spectrometryAnn Chim.(2004 Sep-Oct)
7.^Svehliková V, Bennett RN, Mellon FA, Needs PW, Piacente S, Kroon PA, Bao YIsolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita (L.) Rauschert)Phytochemistry.(2004 Aug)
11.^Hollman PC, Katan MBHealth effects and bioavailability of dietary flavonolsFree Radic Res.(1999 Dec)
12.^Meyer H, Bolarinwa A, Wolfram G, Linseisen JBioavailability of apigenin from apiin-rich parsley in humansAnn Nutr Metab.(2006)
13.^Gradolatto A, Basly JP, Berges R, Teyssier C, Chagnon MC, Siess MH, Canivenc-Lavier MCPharmacokinetics and metabolism of apigenin in female and male rats after a single oral administrationDrug Metab Dispos.(2005 Jan)
14.^Hostetler GL, Ralston RA, Schwartz SJFlavones: Food Sources, Bioavailability, Metabolism, and Bioactivity.Adv Nutr.(2017-May)
15.^Gradolatto A, Basly JP, Berges R, Teyssier C, Chagnon MC, Siess MH, Canivenc-Lavier MCPharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration.Drug Metab Dispos.(2005-Jan)
16.^Ding SM, Zhang ZH, Song J, Cheng XD, Jiang J, Jia XBEnhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion.Int J Nanomedicine.(2014)
17.^Teng Z, Yuan C, Zhang F, Huan M, Cao W, Li K, Yang J, Cao D, Zhou S, Mei QIntestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells.PLoS One.(2012)
18.^Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini ACApigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effectsPlanta Med.(1995 Jun)
20.^Li W, Dai RJ, Yu YH, Li L, Wu CM, Luan WW, Meng WW, Zhang XS, Deng YLAntihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituentsBiol Pharm Bull.(2007 Jun)
22.^Kawai M, Hirano T, Higa S, Arimitsu J, Maruta M, Kuwahara Y, Ohkawara T, Hagihara K, Yamadori T, Shima Y, Ogata A, Kawase I, Tanaka TFlavonoids and related compounds as anti-allergic substancesAllergol Int.(2007 Jun)
23.^Yano S, Umeda D, Yamashita T, Ninomiya Y, Sumida M, Fujimura Y, Yamada K, Tachibana HDietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c miceEur J Nutr.(2007 Aug)
25.^Panés J, Gerritsen ME, Anderson DC, Miyasaka M, Granger DNApigenin inhibits tumor necrosis factor-induced intercellular adhesion molecule-1 upregulation in vivoMicrocirculation.(1996 Sep)
26.^Le Bail JC, Laroche T, Marre-Fournier F, Habrioux GAromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonoidsCancer Lett.(1998 Nov 13)
27.^Li W, Pandey AK, Yin X, Chen JJ, Stocco DM, Grammas P, Wang XEffects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cellsJ Nutr Biochem.(2011 Mar)
28.^Mak P, Leung YK, Tang WY, Harwood C, Ho SMApigenin suppresses cancer cell growth through ERbetaNeoplasia.(2006 Nov)
29.^Ohno S, Shinoda S, Toyoshima S, Nakazawa H, Makino T, Nakajin SEffects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cellsJ Steroid Biochem Mol Biol.(2002 Mar)
30.^Seo EJ, Kuete V, Kadioglu O, Krusche B, Schröder S, Greten HJ, Arend J, Lee IS, Efferth TAntiangiogenic activity and pharmacogenomics of medicinal plants from traditional korean medicineEvid Based Complement Alternat Med.(2013)
32.^O'Prey J, Brown J, Fleming J, Harrison PREffects of dietary flavonoids on major signal transduction pathways in human epithelial cellsBiochem Pharmacol.(2003 Dec 1)
33.^Surh YJCancer chemoprevention with dietary phytochemicalsNat Rev Cancer.(2003 Oct)
34.^Khan TH, Jahangir T, Prasad L, Sultana SInhibitory effect of apigenin on benzo(a)pyrene-mediated genotoxicity in Swiss albino miceJ Pharm Pharmacol.(2006 Dec)
39.^Birt DF, Mitchell D, Gold B, Pour P, Pinch HCInhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoidAnticancer Res.(1997 Jan-Feb)
42.^Menichincheri M, Ballinari D, Bargiotti A, Bonomini L, Ceccarelli W, D'Alessio R, Fretta A, Moll J, Polucci P, Soncini C, Tibolla M, Trosset JY, Vanotti ECatecholic flavonoids acting as telomerase inhibitorsJ Med Chem.(2004 Dec 16)
45.^Kim JS, Eom JI, Cheong JW, Choi AJ, Lee JK, Yang WI, Min YHProtein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemiaClin Cancer Res.(2007 Feb 1)
48.^Lin CM, Chen CT, Lee HH, Lin JKPrevention of cellular ROS damage by isovitexin and related flavonoidsPlanta Med.(2002 Apr)