Creatine is one of the most thoroughly researched compounds, and no adverse side effects have been noted through supplementation.[1][2][3][4][5][6]
Is creatine safe?
Yes.
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References
- Groeneveld GJ, et al. Few adverse effects of long-term creatine supplementation in a placebo-controlled trial . Int J Sports Med. (2005)
- Greenwood M, et al. Creatine supplementation during college football training does not increase the incidence of cramping or injury . Mol Cell Biochem. (2003)
- Lopez RM, et al. Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses . J Athl Train. (2009)
- Greenwood M, et al. Cramping and Injury Incidence in Collegiate Football Players Are Reduced by Creatine Supplementation . J Athl Train. (2003)
- Shao A, Hathcock JN. Risk assessment for creatine monohydrate . Regul Toxicol Pharmacol. (2006)
- Bender A, et al. Long-term creatine supplementation is safe in aged patients with Parkinson disease . Nutr Res. (2008)