CYP2J2 Substrates

    CYP2J2 substrates include, but are not limited to, amiodarone and cyclosporine. See glossary page for more information.


    CYP2J2 substrates are compounds that are metabolized by CYP2J2 (a cytochrome P450 enzyme), but do not necessarily affect its activity. Currently, there are very few medications that are known to rely on CYP2J2 for metabolism.

    In the presence of CYP2J2 inhibitors, the metabolism of CYP2J2 substrates can be reduced. Interestingly, CYP2J2 is not thought to be significantly inducible.

    The table below outlines some of the most common or clinically relevant CYP2J2 substrates.[1][2][3] Importantly, this list is not exhaustive.

    CYP2J2 Substrates


    1. ^Song Y, Li C, Liu G, Liu R, Chen Y, Li W, Cao Z, Zhao B, Lu C, Liu YDrug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes.Clin Pharmacokinet.(2021-May)
    2. ^Zanger UM, Schwab MCytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Pharmacol Ther.(2013-Apr)
    3. ^Hakkola J, Hukkanen J, Turpeinen M, Pelkonen OInhibition and induction of CYP enzymes in humans: an update.Arch Toxicol.(2020-Nov)