CYP2A6 Inducers

    CYP2A6 inducers include, but are not limited to, carbamazepine, dexamethasone, efavirez, oral contraceptives, phenobarbital, and rifampin. See glossary page for more information.


    CYP2A6 inducers are compounds that increase the activity of the CYP2A6 enzyme, which can increase drug metabolism, potentially impacting the effects of drug therapy.

    CYP2A6 is a cytochrome P450 (CYP) enzyme found primarily in the liver that is involved in the metabolism of any medications that are CYP2A6 substrates. However, there are few clinically important drug interactions related to CYP2A6 activity.[1]

    The table below outlines some of the most common or clinically relevant CYP2A6 inducers.[2][3][1] Importantly, this list is not exhaustive.

    CYP2A6 Inducers
    Ethinyl estradiol (oral contraceptives)


    1. ^Hakkola J, Hukkanen J, Turpeinen M, Pelkonen OInhibition and induction of CYP enzymes in humans: an update.Arch Toxicol.(2020-Nov)
    2. ^Song Y, Li C, Liu G, Liu R, Chen Y, Li W, Cao Z, Zhao B, Lu C, Liu YDrug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes.Clin Pharmacokinet.(2021-May)
    3. ^Zanger UM, Schwab MCytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Pharmacol Ther.(2013-Apr)