CYP1A2 Inducers
CYP1A2 inducers include, but are not limited to, carbamazepine, cruciferous vegetables, omeprazole, nelfinavir, phenobarbital, phenytoin, rifampin, ritonavir, and tobacco. See glossary page for more information.
Last Updated:March 14, 2024
Summary
CYP1A2 inducers are compounds that increase the activity of the CYP1A2 enzyme, which can increase drug metabolism, potentially impacting the effects of drug therapy.
CYP1A2 is a cytochrome P450 (CYP) enzyme found mostly in the liver that is involved in the metabolism of any medications that are CYP1A2 substrates; it is perhaps most well-known for its involvement in the metabolism of caffeine.[1] CYP1A2 inducers can increase the body’s metabolism of these substances. CYP1A2 may also play a role in the bioactivation of some carcinogens, like heterocyclic and aromatic amines.[2]
The table below outlines some of the most common or clinically relevant CYP1A2 inducers.[3][1][4] Importantly, this list is not exhaustive.
CYP1A2 Inducers |
---|
Carbamazepine |
Cruciferous vegetables (e.g., broccoli, Brussels sprouts) |
Nelfinavir |
Omeprazole |
Phenobarbital |
Phenytoin |
Rifampin |
Ritonavir |
Tobacco |