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Sex Hormone Binding Globulin

Sex Hormone Binding Globulin (SHBG) is a globulin that is able to bind to and sequester steroid hormones such as estrogen, testosterone, and DHT. Its elevations are associated with less activity of the steroid hormones.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Sex Hormone Binding Globulin.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 4 studies
There appears to be a decrease in SHBG concentrations in older individuals who also experience an increase in androgen/estrogen concentrations, but this is similarly unreliable
grade-b - Very High See all 6 studies
There are no significant alterations in the circulating levels of SHBG seen with red clover supplementation.
grade-c - - See study
In women with PCOS, chromium supplementation does not alter SHBG concentrations in serum.

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Things to Note

Also Known As

SHBG