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Exercise-Induced Oxidation

Physical exercise is associated with an increase in oxidation in the body (which contributes to fatigue, but also mediates beneficial adaptations to exercise), and ingestion of some antioxidant supplements may reduce oxidation and are thought to prolong endurance.

Kamal Patel
Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect exercise-induced oxidation.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b
Coenzyme Q10
Minor Moderate See all 4 studies
Mixed effects on exercise-induced oxidation, but there appears to be some potential for CoQ10 supplementation to reduce oxidation.
grade-b
L-Carnitine
Minor Very High See all 5 studies
A decrease in the exercise-induced increase in MDA levels is seen with carnitine supplementation, possibly secondary to reducing damage to muscle tissue. The degree of MDA reduction is not overly remarkable
grade-c
Methylsulfonylmethane
Notable - See study
A decrease in exercise induced oxidation is noted with MSM supplementation and thought to be the underlying reason for reductions in muscle damage and soreness. The degree of reduction seems to be notable, as the increase in MDA and protein carbonylation were fully abolished

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grade-c
Resveratrol
 
grade-c
Fish Oil
 
grade-c
Green Tea Catechins
 
grade-c
Melatonin
 
grade-c
Astaxanthin
 
grade-c
Phosphatidylserine
 
grade-c
Vitamin C
 
grade-d
Cocoa Extract
 
grade-d
Blueberry
 

This page is regularly updated, to include the most recently available clinical trial evidence.

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This page features 0 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of research information and references for Exercise-Induced Oxidation.

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