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Valine

Valine is one of the three branched chain amino acids, although infrequently tested in isolation and possibly the least important BCAA for body composition and does not appear to have any known unique benefits associated with it.

Our evidence-based analysis on valine features 27 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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Summary of Valine

Primary information, health benefits, side effects, usage, and other important details

Valine is one of the three branched chain amino acids (BCAAs) alongside leucine and isoleucine.

In isolation, there is currently no hugely significant benefit of valine supplementation that cannot be replicated by either leucine or isoleucine supplementation (as the possession of a 'branched chain' itself confers some bioactivity, but this is shared to a degree between all of the BCAAs). This may simply be due to lack of evidence, as many time when valine is researched it is in studies that merely want to test the effects of a branched chain amino acid (and valine is randomly used) and the bioacitivies of valine just haven't been purposefully investigated much.

It seems to be more similar to leucine than it is to isoleucine, but the transient state of insulin resistance occurs faster than with leucine (isoleucine causes glucose uptake) while the muscle building effects of valine are likely less than both leucine and isoleucine.

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How to Take

Recommended dosage, active amounts, other details

There is currently insufficient evidence to suggest an optimal dose of valine supplementation and for what purposes valine supplementation might actually be useful for.

Study Deep Dives

Things to Note

Is a Form Of

Other Functions:

Do Not Confuse With

Branched Chain Amino Acids (a term used to refer to Valine, Leucine and Isoleucine collectively); Norvaline (straight chain analogue of isoleucine)

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Click here to see all 27 references.