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Tinospora cordifolia

Tinospora cordifolia, also known as Guduchi or Amrita, is an immune system boosting herb that can potently reduce the symptoms of allergic rhinitis. It is a promising anti-cancer herb and may provide benefits for people with diabetes.

Our evidence-based analysis on tinospora cordifolia features 101 unique references to scientific papers.

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Summary of Tinospora cordifolia

Primary information, health benefits, side effects, usage, and other important details

Tinospora cordifolia is an herb used in Ayurveda to enhance vitality. It is being researched for a variety of health effects, including its effect on diabetes, glucose metabolism, inflammation, immune system support, and neurology.

Tinospora cordifolia supplementation improves the ability of macrophages, an immune system cell, to consume their targets, though this effect is not immunostimulatory. Supplementation can also ward off allergies. One study suggests Tinospora cordifolia is as potent as Spirulina as an anti-allergic supplement.

Preliminary evidence suggests Tinospora cordifolia may provide benefits for people with diabetes. Supplementation of Tinospora cordifolia can reduce the body’s absorption of sugar-derived carbohydrates, and it may also play a role in reducing the pathologies associated with diabetes, like retinopathy and nephropathy. There is currently no human evidence for these effects.

Tinospora cordifolia may be a monoamine oxidase (MAO) inhibitor, which means it may raise catecholamine levels. The plant may also contain phytoandrogen, which means it can protect against DNA damage induced by the environment and radiation therapy. Finally, Tinospora cordifolia may have Adaptogen-like properties.

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How to Take

Recommended dosage, active amounts, other details

To supplement Tinospora cordifolia, take 1g of a 5% bitters water extract of the stem. The standard dose is 300mg, taken three times a day.

To supplement Amrita Ghrita (Tinospora cordifolia with ghee and ginger), take 10 – 15 g, once a day. This is the traditional Ayurveda dosage.

Tinospora cordifolia should be taken with a meal.

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Human Effect Matrix

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The Human Effect Matrix summarizes human studies to tell you what effects Tinospora cordifolia has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b - High See all 3 studies
Although there was a reduction in neutrophils in the nasal mucosa, the two studies measuring neutrophils in serum failed to find any benefit.
grade-c Strong - See study
At least in regards to allergic rhinitus, oral ingestion of tinospora cordifolia appears to abolish symptoms in 61-83% of persons (depending on symptom) extending to nasal blockage, mucus, pruritis, and sneezing.
grade-c Strong - See study
In persons suffering from allergic rhinitus, nasal congestion is completely resolved in around two-thirds of persons. Currently no studies in nasal congestion for persons without allergies.
grade-c Notable Very High See 2 studies
There appears to be a reduction in eosinophils in the range of 30% or greater, somewhat notable
- See 2 studies
Variable effects on Lymphocytes, with both increases and decreases being noted in persons with allergic rhinitus and no effect being observed in those with HIV.
grade-c Minor Very High See 2 studies
Macrophage activity (phagocytosis and intracellular killing capacity) appears to be preserved when preloaded to surgery, which normally suppresses these parameters.
grade-c Minor - See study
Quite modest reductions in the reported symptoms of HIV when tinospora cordifolia is used as adjuvant therapy
grade-c - - See study
Limited studies looking into CD4+ Lymphocytes have failed to find a stimulatory effect.
grade-c - - See study
Although there were trends for improvement, they failed to be statistically significant and there doesn't seem to be a strong therapeutic effect of tinospora cordifolia
grade-c - - See study
Overall concentrations of T-cells (including CD4+ Lymphocytes) do not appear to be significantly influenced
grade-d Notable Very High See all 3 studies
Topical application of a tinospora cordifolia lotion to youth infected with scabies appears to be comparable in potency to a 5% permethrin lotion as well as Crotamiton (two reference drugs).
grade-d - - See study
The reduction in bilirubin seen with this herb failed to reach statistical significance when used in a clinical setting.

Studies Excluded from Consideration

  • Confounded with Ginger[1] and ginger with ghee[2]

  • Confounded with many ayurvedic herbs[3]

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Things to Note

Primary Function:

Also Known As

Guduchi, makabuhay, Amrita, Giloya, Giloe

Goes Well With

Caution Notice

Possible Interactions with Pregnancy

  • Due to being traditionally used with Ghee (suggesting fat solublility), it may be prudent to consume supplemental tinospora cordifolia with food

  • It is traditionally recommended against using this herb during pregnancy; this has not yet been investigated scientifically but it may be prudent to adhere to this warning

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Click here to see all 101 references.