Thunder god vine

Last Updated: September 28 2022

Tripterygium wilfordii (Thunder God Vine) is a Traditional Chinese Medicine that appears to be effective for the treatment of inflammatory and autoimmune diseases, but has toxicity associated per se and a low therapeutic threshold.

Thunder god vine is most often used for

What else is Thunder god vine known as?
Note that Thunder god vine is also known as:
  • Thunder God Vine
  • Tripterygium Wilfordii
Dosage information

It should be noted that this plant has a very low therapeutic index (difference between the effective dose and the toxic dose) and that overdosing is both easy to do and critical; supplementation is usually avoided for this reason.

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1.^Salminen A, Lehtonen M, Paimela T, Kaarniranta KCelastrol: Molecular targets of Thunder God VineBiochem Biophys Res Commun.(2010 Apr 9)
2.^Zhang Y, Chen L, Xu W, Li H, Zhang X, Xia Y, Chu KTherapeutic effects of total alkaloids of Tripterygium wilfordii Hook f. on collagen-induced arthritis in ratsJ Ethnopharmacol.(2012 Nov 23)
6.^Fang W, Peng F, Yi T, Zhang C, Wan C, Xu H, Lam CW, Yang XBiological activity and safety of Tripterygium extract prepared by sodium carbonate extractionMolecules.(2012 Sep 17)
11.^Li W, Liu Y, He YQ, Zhang JW, Gao Y, Ge GB, Liu HX, Huo H, Liu HT, Wang LM, Sun J, Wang Q, Yang LCharacterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomesXenobiotica.(2008 Dec)
12.^Papakostas D, Rancan F, Sterry W, Blume-Peytavi U, Vogt ANanoparticles in dermatologyArch Dermatol Res.(2011 Oct)
13.^Xue M, Jiang ZZ, Wu T, Li J, Zhang L, Zhao Y, Li XJ, Zhang LY, Yang SYAnti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in ratsPhytomedicine.(2012 Aug 15)
15.^Xue M, Jiang ZZ, Wu T, Yan M, Liu JP, Mu XM, Su YW, Zhang LYProtective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in ratsArzneimittelforschung.(2011)
19.^Salminen A, Paimela T, Suuronen T, Kaarniranta KInnate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90Immunol Lett.(2008 Apr 15)
20.^Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, Kim S, Gu W, Devlin JP, Silverman RB, Morimoto RICelastrols as inducers of the heat shock response and cytoprotectionJ Biol Chem.(2004 Dec 31)
22.^Kim Y, Kim K, Lee H, Han S, Lee YS, Choe J, Kim YM, Hahn JH, Ro JY, Jeoung DCelastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effectEur J Pharmacol.(2009 Jun 10)
24.^Chen P, Han R, Zhou Q, Cheng H, Zhu KModulatory effect of triptolide on differentiation of human Th17 cellsZhongguo Zhong Yao Za Zhi.(2011 Jun)
25.^Wu C, Xia Y, Wang P, Lu L, Zhang FTriptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 productionInt Immunopharmacol.(2011 Oct)
26.^Rose-John S, Mitsuyama K, Matsumoto S, Thaiss WM, Scheller JInterleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel diseaseCurr Pharm Des.(2009)
27.^Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DRThe orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsCell.(2006 Sep 22)
28.^Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano TIL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady stateInt Immunol.(2007 Jun)
30.^Trott A, West JD, Klaić L, Westerheide SD, Silverman RB, Morimoto RI, Morano KAActivation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted moleculeMol Biol Cell.(2008 Mar)
31.^Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren JKnockout of hepatic P450 reductase aggravates triptolide-induced toxicityToxicol Lett.(2011 Aug 10)
32.^Ye X, Li W, Yan Y, Mao C, Cai R, Xu H, Yang XEffects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in ratToxicol Lett.(2010 Feb 1)
33.^Zhang Z, Zheng Q, Han J, Gao G, Liu J, Gong T, Gu Z, Huang Y, Sun X, He QThe targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cellsBiomaterials.(2009 Mar)
34.^Chadli A, Felts SJ, Wang Q, Sullivan WP, Botuyan MV, Fauq A, Ramirez-Alvarado M, Mer GCelastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23J Biol Chem.(2010 Feb 5)
35.^Liu J, Jiang Z, Xiao J, Zhang Y, Lin S, Duan W, Yao J, Liu C, Huang X, Wang T, Liang Z, Wang R, Zhang S, Zhang LEffects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell linesPhytomedicine.(2009 Nov)
36.^Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, Dou QPDietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cellsBiochem Pharmacol.(2005 May 15)
38.^Krantic S, Mechawar N, Reix S, Quirion RApoptosis-inducing factor: a matter of neuron life and deathProg Neurobiol.(2007 Feb)
39.^Zhou R, Zhang F, He PL, Zhou WL, Wu QL, Xu JY, Zhou Y, Tang W, Li XY, Yang YF, Li YC, Zuo JP(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivoInt Immunopharmacol.(2005 Dec)
40.^Grzegorzewska AE, Frankiewicz D, Bręborowicz D, Matławska I, Bylka WDisseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritisMed Sci Monit.(2012 Aug)