Thunder god vine
•Last Updated: September 28 2022
Tripterygium wilfordii (Thunder God Vine) is a Traditional Chinese Medicine that appears to be effective for the treatment of inflammatory and autoimmune diseases, but has toxicity associated per se and a low therapeutic threshold.
Thunder god vine is most often used for
Last Updated: September 28 2022
Note that Thunder god vine is also known as:
- Thunder God Vine
- Tripterygium Wilfordii
It should be noted that this plant has a very low therapeutic index (difference between the effective dose and the toxic dose) and that overdosing is both easy to do and critical; supplementation is usually avoided for this reason.
1.^Salminen A, Lehtonen M, Paimela T, Kaarniranta KCelastrol: Molecular targets of Thunder God VineBiochem Biophys Res Commun.(2010 Apr 9)
2.^Zhang Y, Chen L, Xu W, Li H, Zhang X, Xia Y, Chu KTherapeutic effects of total alkaloids of Tripterygium wilfordii Hook f. on collagen-induced arthritis in ratsJ Ethnopharmacol.(2012 Nov 23)
3.^Canter PH, Lee HS, Ernst EA systematic review of randomised clinical trials of Tripterygium wilfordii for rheumatoid arthritisPhytomedicine.(2006 May)
4.^Huang M, Zhang H, Liu T, Tian D, Gu L, Zhou MTriptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathwayMol Cancer Ther.(2012 Dec 12)
5.^Zhao JW, Wang GH, Chen M, Cheng LH, Ji XQDemethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7Molecules.(2012 Aug 8)
6.^Fang W, Peng F, Yi T, Zhang C, Wan C, Xu H, Lam CW, Yang XBiological activity and safety of Tripterygium extract prepared by sodium carbonate extractionMolecules.(2012 Sep 17)
7.^Yang H, Chen D, Cui QC, Yuan X, Dou QPCelastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude miceCancer Res.(2006 May 1)
8.^Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid.()
9.^Sreeramulu S, Gande SL, Göbel M, Schwalbe HMolecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrolAngew Chem Int Ed Engl.(2009)
11.^Li W, Liu Y, He YQ, Zhang JW, Gao Y, Ge GB, Liu HX, Huo H, Liu HT, Wang LM, Sun J, Wang Q, Yang LCharacterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomesXenobiotica.(2008 Dec)
12.^Papakostas D, Rancan F, Sterry W, Blume-Peytavi U, Vogt ANanoparticles in dermatologyArch Dermatol Res.(2011 Oct)
13.^Xue M, Jiang ZZ, Wu T, Li J, Zhang L, Zhao Y, Li XJ, Zhang LY, Yang SYAnti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in ratsPhytomedicine.(2012 Aug 15)
14.^Liu M, Dong J, Yang Y, Yang X, Xu HAnti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in ratsJ Ethnopharmacol.(2005 Feb 28)
15.^Xue M, Jiang ZZ, Wu T, Yan M, Liu JP, Mu XM, Su YW, Zhang LYProtective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in ratsArzneimittelforschung.(2011)
16.^Mei Z, Li X, Wu Q, Hu S, Yang XThe research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticlePharmacol Res.(2005 Apr)
17.^Pharmacologic inhibitors of IκB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo.()
18.^Sethi G, Ahn KS, Pandey MK, Aggarwal BBCelastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activationBlood.(2007 Apr 1)
19.^Salminen A, Paimela T, Suuronen T, Kaarniranta KInnate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90Immunol Lett.(2008 Apr 15)
20.^Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, Kim S, Gu W, Devlin JP, Silverman RB, Morimoto RICelastrols as inducers of the heat shock response and cytoprotectionJ Biol Chem.(2004 Dec 31)
22.^Kim Y, Kim K, Lee H, Han S, Lee YS, Choe J, Kim YM, Hahn JH, Ro JY, Jeoung DCelastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effectEur J Pharmacol.(2009 Jun 10)
23.^Wang Y, Jia L, Wu CYTriptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritisScand J Immunol.(2008 Oct)
24.^Chen P, Han R, Zhou Q, Cheng H, Zhu KModulatory effect of triptolide on differentiation of human Th17 cellsZhongguo Zhong Yao Za Zhi.(2011 Jun)
25.^Wu C, Xia Y, Wang P, Lu L, Zhang FTriptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 productionInt Immunopharmacol.(2011 Oct)
26.^Rose-John S, Mitsuyama K, Matsumoto S, Thaiss WM, Scheller JInterleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel diseaseCurr Pharm Des.(2009)
27.^Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DRThe orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsCell.(2006 Sep 22)
28.^Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano TIL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady stateInt Immunol.(2007 Jun)
29.^Li Y, Yu C, Zhu WM, Xie Y, Qi X, Li N, Li JSTriptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17Mol Immunol.(2010 Sep)
30.^Trott A, West JD, Klaić L, Westerheide SD, Silverman RB, Morimoto RI, Morano KAActivation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted moleculeMol Biol Cell.(2008 Mar)
31.^Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren JKnockout of hepatic P450 reductase aggravates triptolide-induced toxicityToxicol Lett.(2011 Aug 10)
32.^Ye X, Li W, Yan Y, Mao C, Cai R, Xu H, Yang XEffects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in ratToxicol Lett.(2010 Feb 1)
33.^Zhang Z, Zheng Q, Han J, Gao G, Liu J, Gong T, Gu Z, Huang Y, Sun X, He QThe targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cellsBiomaterials.(2009 Mar)
34.^Chadli A, Felts SJ, Wang Q, Sullivan WP, Botuyan MV, Fauq A, Ramirez-Alvarado M, Mer GCelastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23J Biol Chem.(2010 Feb 5)
35.^Liu J, Jiang Z, Xiao J, Zhang Y, Lin S, Duan W, Yao J, Liu C, Huang X, Wang T, Liang Z, Wang R, Zhang S, Zhang LEffects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell linesPhytomedicine.(2009 Nov)
36.^Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, Dou QPDietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cellsBiochem Pharmacol.(2005 May 15)
37.^Lee JH, Won YS, Park KH, Lee MK, Tachibana H, Yamada K, Seo KICelastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signalingApoptosis.(2012 Dec)
38.^Krantic S, Mechawar N, Reix S, Quirion RApoptosis-inducing factor: a matter of neuron life and deathProg Neurobiol.(2007 Feb)
39.^Zhou R, Zhang F, He PL, Zhou WL, Wu QL, Xu JY, Zhou Y, Tang W, Li XY, Yang YF, Li YC, Zuo JP(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivoInt Immunopharmacol.(2005 Dec)
40.^Grzegorzewska AE, Frankiewicz D, Bręborowicz D, Matławska I, Bylka WDisseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritisMed Sci Monit.(2012 Aug)
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