Pygeum

Last Updated: September 28 2022

Pygeum is an extract made from the the bark of the Prunus africana tree. It is commonly sold as a supplement for prostate health.

Pygeum is most often used for

Summary

Pygeum is an herbal supplement derived from the bark of the Prunus africana tree.

Pygeum is often sold as a prostate health supplement, specifically to alleviate Benign Prostatic Hyperplasia (BPH), also called benign enlargement of the prostate.

Further research is needed to determine if pygeum does exert this protective effect. Though one meta-analysis showed pygeum supplementation provides overall benefits for BPH, subsequent studies suffered from poor design and do not provide strong evidence.

Pygeum has been shown to reduce BPH proliferation in vitro (in a test tube) by interfering with growth factors. It also has an anti-androgenic effect on its receptor. Additional studies are needed to determine if this effect takes place inside the human body after oral supplementation.

What else is Pygeum known as?
Pygeum should not be confused with:
  • Pycnogeol (Pine bark extract)
Dosage information

Most prostate health supplements and scientific studies use a dose of 50-100mg of pygeum , taken daily.

Additional research is needed to determine the optimal dose of pygeum bark.

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References
1.^Hutchison A, Farmer R, Verhamme K, Berges R, Navarrete RVThe efficacy of drugs for the treatment of LUTS/BPH, a study in 6 European countriesEur Urol.(2007 Jan)
4.^Strong KMAfrican plum and benign prostatic hypertrophyJ Herb Pharmacother.(2004)
5.^Paubert-Braquet M, Cave A, Hocquemiller R, Delacroix D, Dupont C, Hedef N, Borgeat PEffect of Pygeum africanum extract on A23187-stimulated production of lipoxygenase metabolites from human polymorphonuclear cellsJ Lipid Mediat Cell Signal.(1994 May)
6.^Schleich S, Papaioannou M, Baniahmad A, Matusch RExtracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activityPlanta Med.(2006 Jul)
7.^Schleich S, Papaioannou M, Baniahmad A, Matusch RActivity-guided isolation of an antiandrogenic compound of Pygeum africanumPlanta Med.(2006 May)
8.^Kadu CA, Parich A, Schueler S, Konrad H, Muluvi GM, Eyog-Matig O, Muchugi A, Williams VL, Ramamonjisoa L, Kapinga C, Foahom B, Katsvanga C, Hafashimana D, Obama C, Vinceti B, Schumacher R, Geburek TBioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parametersPhytochemistry.(2012 Nov)
10.^Hass MA, Nowak DM, Leonova E, Levin RM, Longhurst PAIdentification of components of Prunus africana extract that inhibit lipid peroxidationPhytomedicine.(1999 Nov)
12.^Catalano S, Ferretti M, Marsili A, Morelli INew constituents of Prunus africana bark extractJ Nat Prod.(1984 Sep-Oct)
15.^Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DBPhytosterol Pygeum africanum regulates prostate cancer in vitro and in vivoEndocrine.(2007 Feb)
17.^Papaioannou M, Schleich S, Roell D, Schubert U, Tanner T, Claessens F, Matusch R, Baniahmad ANBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growthInvest New Drugs.(2010 Dec)
18.^Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman D Jr, Farquhar R, Guo Z, Qiu Y, Brodie AMNovel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft modelJ Med Chem.(2005 Apr 21)
19.^Mathé G, Orbach-Arbouys S, Bizi E, Court BThe so-called phyto-estrogenic action of Pygeum africanum extractBiomed Pharmacother.(1995)
20.^Papaioannou M, Schleich S, Prade I, Degen S, Roell D, Schubert U, Tanner T, Claessens F, Matusch R, Baniahmad AThe natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate cancer cell growthJ Cell Mol Med.(2009 Aug)
21.^Bach SM, Perotti ME, Merep AP, Marcial GE, Grau A, Attarian R, Av-Gay Y, Bach H, Catalán CAChemical constituents, anti-inflammatory and antioxidant activities of bark extracts from Prunus tucumanensis LilloNat Prod Res.(2012 Mar 9)
22.^Boulbès D, Soustelle L, Costa P, Haddoum M, Bali JP, Hollande F, Magous RPygeum africanum extract inhibits proliferation of human cultured prostatic fibroblasts and myofibroblastsBJU Int.(2006 Nov)
24.^Yablonsky F, Nicolas V, Riffaud JP, Bellamy FAntiproliferative effect of Pygeum africanum extract on rat prostatic fibroblastsJ Urol.(1997 Jun)
26.^Larré S, Camparo P, Comperat E, Boulbés D, Haddoum M, Baulande S, Soularue P, Costa P, Cussenot OBiological effect of human serum collected before and after oral intake of Pygeum africanum on various benign prostate cell culturesAsian J Androl.(2012 May)
27.^Wilt T, Ishani A, Mac Donald R, Rutks I, Stark GPygeum africanum for benign prostatic hyperplasiaCochrane Database Syst Rev.(2002)
34.^Kaplan SA, Blaivas JGDiabetic cystopathyJ Diabet Complications.(1988 Jul-Sep)
37.^Wang D, Li Y, Hou G, Wang P, Zhang J, Laudon V, Shi BPygeum africanum: effect on oxidative stress in early diabetes-induced bladderInt Urol Nephrol.(2010 Jun)