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Pueraria mirifica

Pueraria Candollei var. Mirifica (White Kwao Krua) is a highly estrogenic herb (main bioactive, Deoxymiroestrol, being more potent than estrogen itself) which is used as herbal estrogen replacement therapy. It appears effective, but lacks blinded studies.

Our evidence-based analysis on pueraria mirifica features 66 unique references to scientific papers.

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Summary of Pueraria mirifica

Primary information, health benefits, side effects, usage, and other important details

Pueraria Candollei variant Mirifica (shortened to Pueraria Mirifica) is one of three herbs given the title of 'Kwao Krua', and is known as White Kwao Krua. This herb has been traditionally used as a vitality enhancer and rejuvenating agent particularly for older women. It should be considered a different supplement than Kudzu root, Pueraria Lobata.

When looking at the herb, it is a great source of classical phytoestrogens (including the soy isoflavones) but contains a class of phytoestrogens known as Chromenes that rival estrogen itself in potency. The herb is highly estrogenic as a result, and is considered the standard herbal 'estrogen replacement therapy' due to its potencies.

It has been tested numerous times for reducing menopausal symptoms (as estrogen replacement therapy itself is quite effective), and despite the universal promise it shows many studies are not blinded and not run against a placebo; on the topic of menopausal symptoms, this is a significant problem as placebo can be very potent (see Black Cohosh as an example, as the placebo effect in menopause has been reported to reach up to a 50% reduction in symptoms).

Based on the preliminary evidence, it does appear promising and effective for menopausal symptoms, but much more research is needed before it can be considered a main opinion. There is currently no evidence to support the notion that this herb is somehow safer than estrogen replacement therapy, so their benefits and risks should be seen as interchangeable for the time being.

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How to Take

Recommended dosage, active amounts, other details

In regards to Pueraria Mirifica (White Kwao Krua), a dose of 20-50mg of the herb is taken daily once in the morning. This appears to be significantly bioactive, and it would be advisable to not exceed this dosage.

And if you are a man who wants to take 'Pueraria' for hangovers, ensure you don't get the estrogen replacement therapy (this supplement) by accident. The herb touted to cure hangovers is Pueraria Lobata (Kudzu), and although it is not a common mistake it is indeed a critical one to make.

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Pueraria mirifica has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Notable Very High See all 4 studies
The effects of Pueraria Mirifica on menopausal symptoms appear to be potent, with one study suggesting comparable efficacy to estrogen replacement therapy itself. Requires more robust evidence, however.
grade-c Minor - See study
A slight decrease in Apolipoprotein B has been noted with Pueraria Mirifica
grade-c Minor - See study
Efficacy has been noted (and suggests long term bone regenerative properties) but requires more evidence to establish overall potency relative to other estrogenic agents
grade-c Minor - See study
Not overly potent, only testing in menopausal women has been conducted
grade-c Minor - See study
Somewhat effective in menopausal women.
grade-c Minor - See study
Was able to reduce vaginal dryness (due to estrogenic effects, perhaps) although potency cannot be judged well due to no comparator.

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Things to Note

Primary Function:

Also Known As

White Kwao Krua

Do Not Confuse With

Black Kwao Krua (Mucuna collettii), Red Kwao Krua (Butea superba), Psoralea Corylifolia, Pueraria Lobata (Kudzu)

Caution Notice

Due to being highly estrogenic, supplemental Pueraria Mirifica carries the same potential risks of estrogen replacement therapy; as such, it should not be used in persons with high cancer risk or survivors of cancer of the breast or uterus

And if you are a guy who wants to take 'Pueraria' for hangovers, ensure you don't get the estrogen replacement therapy by accident. The hangover one is Pueraria Lobata (Kudzu)

  • This herb is highly estrogenic

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Click here to see all 66 references.