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PRL-8-53

PRL-8-53 is a synthetic supplement with potential benefits for short term memory. More evidence is needed for its effects, since all current evidence comes from a study funded by the patent holder.

Our evidence-based analysis on prl-8-53 features 3 unique references to scientific papers.

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Summary of PRL-8-53

Primary Information, Benefits, Effects, and Important Facts

PRL-8-53 is a synthetic nootropic supplement, meaning it was created in a lab. Its full name is methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate.

Researchers found that oral supplementation of PRL-8-53 was able to improve avoidance learning in rats. One human study has also been done on PRL-8-53. Each participant ingested a placebo and PRL-8-53, at separate times, in a double blind crossover study. Participants then took a memory test, consisting of twelve monosyllabic words in a particular order. The test was conducted three times, immediately after supplementation, one day after supplementation, and four days after supplementation.

People that remembered more than eight words after taking a placebo experienced minor benefits, but people over 30 or with poor short term memory benefitted greatly from supplementation. In some cases, their score on the word test doubled.

No side effects were observed in the human study, and preliminary rodent evidence suggests PRL-8-53 is safe. Using PRL-8-53 as a dietary supplement, however, cannot be recommended at this time because it is a synthetic substance and all of the evidence for its effects comes from studies funded by the holder of the patent. Though this link should not invalidate the available evidence, independent replication would go a long way toward confirming PRL-8-53’s efficacy.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

More evidence is needed to determine the ideal dosage for PRL-8-53. The effective dosage may vary, since the only human study on PRL-8-53 used a single dose of 5mg, while patent information on PRL-8-53 suggests a dosage range of 0.01-4mg/kg, with an 'ideal' range of 0.05-1.2mg/kg.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects prl-8-53 has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Notable - See study
The lone study noted mild increases in memory (14%) bordering on statistical significance in high performers on a word recollection test, with higher performances in subjects over the age of 30 regardless of initial performance (108-152% increase over placebo performance) and in poor performers (87.5-105%).
grade-c Minor - See study
Memory acquisition appears to be mildly increased in the range of 18-31% in persons with poorer performance on a word recollection memory test, but is not improved in high performers.
grade-c - - See study
Supplementation of 5mg PRL-8-53 has failed to improve hand motor control following supplementation.
grade-c - - See study
The dose of PRL-8-53 that improves memory formation does not appear to have any significant influence on reaction time.

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Things to Note

Is a Form Of

Also Known As

Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate

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Click here to see all 3 references.