Last Updated: September 28 2022

PRL-8-53 is a synthetic supplement with potential benefits for short term memory. More evidence is needed for its effects, since all current evidence comes from a study funded by the patent holder.

PRL-8-53 is most often used for


PRL-8-53 is a synthetic nootropic supplement, meaning it was created in a lab. Its full name is methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate.

Researchers found that oral supplementation of PRL-8-53 was able to improve avoidance learning in rats. One human study has also been done on PRL-8-53. Each participant ingested a placebo and PRL-8-53, at separate times, in a double blind crossover study. Participants then took a memory test, consisting of twelve monosyllabic words in a particular order. The test was conducted three times, immediately after supplementation, one day after supplementation, and four days after supplementation.

People that remembered more than eight words after taking a placebo experienced minor benefits, but people over 30 or with poor short term memory benefitted greatly from supplementation. In some cases, their score on the word test doubled.

No side effects were observed in the human study, and preliminary rodent evidence suggests PRL-8-53 is safe. Using PRL-8-53 as a dietary supplement, however, cannot be recommended at this time because it is a synthetic substance and all of the evidence for its effects comes from studies funded by the holder of the patent. Though this link should not invalidate the available evidence, independent replication would go a long way toward confirming PRL-8-53’s efficacy.

What else is PRL-8-53 known as?
Note that PRL-8-53 is also known as:
  • Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate
Dosage information

More evidence is needed to determine the ideal dosage for PRL-8-53. The effective dosage may vary, since the only human study on PRL-8-53 used a single dose of 5mg, while patent information on PRL-8-53 suggests a dosage range of 0.01-4mg/kg, with an 'ideal' range of 0.05-1.2mg/kg.

Join our supplement information course

Enter your email to get a FREE five-day course on supplements. 100% backed by science, we take an independent and unbiased approach to figure out what works (and what's a waste of time and money).

    The only 100% independent company. While everyone sells supplements, we only analyze research.

    Don't miss out on the latest research

    Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more