Pramiracetam

    Researchedby:
    Kamal Patel
    Last Updated: September 28, 2022

    Pramiracetam is a synthetic racetam derivative for the purpose of cognitive enhancement, with preliminary evidence to support its usage in aiding long-term memory formation. Although the mechanisms are not well known at all, it might enhance acetylcholine synthesis.

    examine-databaseExamine Database

    Pramiracetam is most often used for .

    63 participants in 3 trials

    Summary

    Pramiracetam is a racetam molecule that was initially synthesized from piracetam due to its modifications having more anti-amnesiac potential in rats. Relative to the other racetams, pramiracetam is not that well researched but does appear to have some human evidence.

    When looking at the animal evidence, otherwise healthy young and old rats seem to experience benefits to long-term memory formation with supplementation of pramiracetam. It appears to be effective when taken acutely (1-2 hours) before cognitive testing, and studies looking at working memory do not note much effects. Human studies support this, but they are limited in statistical power and currently there are no human studies in otherwise healthy youth for the purpose of cognitive enhancement.

    The mechanisms of pramiracetam are not well known, but it appears to alter EEG activity in all tested rats (young and old) and may be able to enhance high-affinity choline uptake. It is similar to piracetam and other racetams in the sense that its mechanisms seem dependent on the adrenal glands and some peripheral effects, but beyond that the mechanisms have not been further elucidated.

    What are other names for Pramiracetam

    Note that Pramiracetam is also known as:
    • CI-879 Diisoprop-yl-(2-oxopyrrolidin-1-yl)acetamide CI879
    Pramiracetam should not be confused with:
    • Piracetam (Basic racetam but different molecule)

    Dosage information

    Currently, the evidence using pramiracetam in humans uses either 400mg thrice daily or 600mg twice daily; both of these dosing regiments totals 1,200mg of pramiracetam daily.

    It is unsure if pramiracetam should be taken with meals, and it is not clear if 1,200mg is the optimal dosage or not. This dose, however, does appear effective.

    Examine Database: Pramiracetam

    Examine Database References

    1. Memory - McLean A Jr, Cardenas DD, Burgess D, Gamzu EPlacebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxiaBrain Inj.(1991 Oct-Dec)
    2. Forgetting - Mauri M, Sinforiani E, Reverberi F, Merlo P, Bono GPramiracetam effects on scopolamine-induced amnesia in healthy volunteersArch Gerontol Geriatr.(1994 Mar-Apr)
    3. Memory - De Vreese LP, Neri M, Boiardi R, Ferrari P, Belloi L, Salvioli GMemory training and drug therapy act differently on memory and metamemory functioning: evidence from a pilot studyArch Gerontol Geriatr.(1996)