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Pramiracetam

Pramiracetam is a synthetic racetam derivative for the purpose of cognitive enhancement, with preliminary evidence to support its usage in aiding long-term memory formation. Although the mechanisms are not well known at all, it might enhance acetylcholine synthesis.

Our evidence-based analysis on pramiracetam features 25 unique references to scientific papers.

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Summary of Pramiracetam

Primary information, health benefits, side effects, usage, and other important details

Pramiracetam is a racetam molecule that was initially synthesized from piracetam due to its modifications having more anti-amnesiac potential in rats. Relative to the other racetams, pramiracetam is not that well researched but does appear to have some human evidence.

When looking at the animal evidence, otherwise healthy young and old rats seem to experience benefits to long-term memory formation with supplementation of pramiracetam. It appears to be effective when taken acutely (1-2 hours) before cognitive testing, and studies looking at working memory do not note much effects. Human studies support this, but they are limited in statistical power and currently there are no human studies in otherwise healthy youth for the purpose of cognitive enhancement.

The mechanisms of pramiracetam are not well known, but it appears to alter EEG activity in all tested rats (young and old) and may be able to enhance high-affinity choline uptake. It is similar to piracetam and other racetams in the sense that its mechanisms seem dependent on the adrenal glands and some peripheral effects, but beyond that the mechanisms have not been further elucidated.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Currently, the evidence using pramiracetam in humans uses either 400mg thrice daily or 600mg twice daily; both of these dosing regiments totals 1,200mg of pramiracetam daily.

It is unsure if pramiracetam should be taken with meals, and it is not clear if 1,200mg is the optimal dosage or not. This does, however, does appear effective.

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix summarizes human studies to tell you what effects Pramiracetam has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor - See study
Appears to decrease the influence of amnesiac drugs (scopolamine), and is effective when loaded over a few days rather than relying on acute administration
grade-d Minor - See study
Cognitive ability in youth who experienced brain trauma is improved with prolonged usage of pramiracetam, suggesting neuroprotective effects
grade-d Minor Very High See 2 studies
While it appears effective in promoting memory formation in elderly persons and cognitively injured youth, there is currently no evidence in otherwise healthy use for nootropic purposes
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Things to Note

Is a Form Of

Also Known As

CI-879, Diisoprop-yl-(2-oxopyrrolidin-1-yl)acetamide, CI879

Do Not Confuse With

Piracetam (Basic racetam, but different molecule)

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Click here to see all 25 references.