Last Updated: September 28 2022

Phenylpiracetam (Phenotropil) is a racetam drug derived from Piracetam in where the only modification is the addition of a phenyl group to its structure. It appears to require much lower doses for similar properties, and appears to have psychostimulatory effects.

Phenylpiracetam is most often used for


Phenylpiracetam (Phenotropil) is a nootropic of the racetam family, and as its name suggests it is a phenyl- derivative of piracetam. Phenylpiracetam is reported to be more neuroprotective than piracetam is, but also possesses psychostimulatory properties and is reported to enhance physical performance.

There is a fair bit of research to suggest that phenylpiracetam is effective, like other racetam drugs, in attenuating the rate of and symptoms of cognitive decline. Many of these studies use phenylpiracetam for over one month's time, and the benefits seen may only apply to organic causes of cognitive decline (dementia and stroke) rather than traumatic brain injury.

There is only one rat study noting cognitive enhacement in otherwise healthy young rats, and this study only noted benefit with the R-isomer (the racemic mixture, which is commonly sold, failed to outperform control). While cognitive enhancing propertes of phenylpiracetam in youth cannot be ruled out, they are possibly distinct from the psychostimulatory properties (which occur with said racemic mixture and the R-isomer).

What else is Phenylpiracetam known as?
Note that Phenylpiracetam is also known as:
  • Phenotropil
  • Carphedon
  • (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide
Phenylpiracetam should not be confused with:
Dosage information

Phenylpiracetam is taken at a dosage of 100-200mg acutely, and this dose is taken 2-3 times per day (totalling a daily range of 200-600mg). The lower range seems effective, but the optimal dosage is not yet known.

The R-isomer appears to be more active on the common usages of phenylpiracetam (stimulation and cognition) than does the S-isomer, and while the racemic mixture (commonly sold version) is effective for cognitive decline it is not certain if it works for nootropic purposes in youth.

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3.^Bobkov IuG, Morozov IS, Glozman OM, Nerobkova LN, Zhmurenko LAPharmacological characteristics of a new phenyl analog of piracetam--4-phenylpiracetamBiull Eksp Biol Med.(1983 Apr)
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