Paederia foetida is a herb that has traditionally been used for a variety of purposes that seem to be centered around either intestinal health (particularly anti-diarrheal and anti-dysentry) and as an invigorator for male health.
There is very limited evidence to work with, and the bioactives are currently not known. It appears to have typical anti-oxidant and anti-inflammatory effects that are common to most herbs, with no evidence to suspect that either of those mechanisms is remarkable.
One study has noted a dose and time depenendent increase in semen production and testosterone secretion in male rats, coupled with aphrodisiac effects and erectogenic effects; this preliminary study supports the notion that this herb can enhance male vigor and vitality but needs replication. Investigating the main bioactive would also be prudent.
Although there is no known toxic effects associated with this herb at this moment in time, there has not been much toxicity research conducted.