Quick Navigation

Noopept

Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester, a Nootropic molecule similar to Piracetam. Noopept may alleviate cognitive decline.

Our evidence-based analysis on noopept features 44 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Summary of Noopept

Primary Information, Benefits, Effects, and Important Facts

Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester , a synthetic nootropic molecule.

Noopept has a similar effect to piracetam, in that it provides a mild cognitive boost after supplementation. Noopept also provides a subtle psychostimulatory effect.

Noopept has a much lower standard dose than piracetam (10-30mg, compared to 4800mg), and it provides a general neuroprotective effect after supplementation. This neuroprotective effect occurs during various states of cognitive trauma, including oxidative stress and physical trauma. There is, however, no evidence to suggest Noopept provides benefits for people with no cognitive ailments.

More studies are needed to determine the main mechanisms responsible for Noopept’s neuroprotective effect.

The only human study comparing Noopept and piracetam suggests the two have a comparable effect, once the smaller effective dose is taken into account.

Get unbiased information on what works

At Examine.com, we pride ourselves on basing all our recommendations on evidence. It’s why we don’t sell any advertising or supplements — so that you know that our analysis is unbiased.

If you’re tired of wasting time and money on supplements that don’t work, our 17 Supplement Guides will help you figure out precisely what to take — and what to skip — based on your health goals and the latest scientific evidence.

Join over 50,000 people who rely on Examine.com's unbiased and science-based analysis.


I want unbiased recommendations »

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

To supplement Noopept, take 10 – 30 mg, once a day, for up to 56 days at a time. More research is needed to determine the optimal human dose for Noopept.

Get the latest information on 400+ supplements and their effects on 500+ health outcomes.

By becoming an Examine Plus member, you'll have access to all of the latest nutrition research. Quickly and easy look up evidence on over 400 supplements across over 500 different health goals, outcomes, conditions, and more.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects noopept has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d Notable - See study
The one trial with Noopept suggests surprisingly effective rehabilitative effects, outperforming Piracetam as comparator.

Get access to the latest nutrition research

By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 300 supplements across over 500 different health goals, outcomes, conditions, and more.

Things to Note

Is a Form Of

Also Known As

N-phenylacetyl-L-prolylglycine ethyl ester, Noopeptide, Ноопепт, GVS-111

Do Not Confuse With

Piracetam (Basic racetam, but different molecule)

  • Noopept is not technically a racetam molecule (due to not having a 2-oxo-pyrollidine skeleton), but is generally grouped together in the same category

Tired of misinformation? Get unbiased info on supplements.

At Examine.com, our incentives line up with yours — getting unbiased information. It’s why we don’t sell any advertising or supplements.

Join over 250,000 people who’ve learned about effective versus overrated supplements, supplement buying tips, and how to combine supplements for safety and efficacy.

Click here to see all 44 references.