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Noopept

Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester, a Nootropic molecule similar to Piracetam. Noopept may alleviate cognitive decline.

Our evidence-based analysis on noopept features 44 unique references to scientific papers.

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Summary of Noopept

Primary information, health benefits, side effects, usage, and other important details

Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester , a synthetic nootropic molecule.

Noopept has a similar effect to piracetam, in that it provides a mild cognitive boost after supplementation. Noopept also provides a subtle psychostimulatory effect.

Noopept has a much lower standard dose than piracetam (10-30mg, compared to 4800mg), and it provides a general neuroprotective effect after supplementation. This neuroprotective effect occurs during various states of cognitive trauma, including oxidative stress and physical trauma. There is, however, no evidence to suggest Noopept provides benefits for people with no cognitive ailments.

More studies are needed to determine the main mechanisms responsible for Noopept’s neuroprotective effect.

The only human study comparing Noopept and piracetam suggests the two have a comparable effect, once the smaller effective dose is taken into account.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

To supplement Noopept, take 10 – 30 mg, once a day, for up to 56 days at a time. More research is needed to determine the optimal human dose for Noopept.

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix summarizes human studies to tell you what effects Noopept has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d Notable - See study
The one trial with Noopept suggests surprisingly effective rehabilitative effects, outperforming Piracetam as comparator.

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Things to Note

Is a Form Of

Also Known As

N-phenylacetyl-L-prolylglycine ethyl ester, Noopeptide, Ноопепт, GVS-111

Do Not Confuse With

Piracetam (Basic racetam, but different molecule)

  • Noopept is not technically a racetam molecule (due to not having a 2-oxo-pyrollidine skeleton), but is generally grouped together in the same category

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Click here to see all 44 references.