Haninjin

Last Updated: August 17 2022

Artemisia iwayomogi (Haninjin) has limited traditional use, but as of late is being investigated for anti-cancer properties. At least one study suggests possible fat-burning effects, and immune-system interactions may be present.

Haninjin is most often used for

Summary

Artemisia iwayomogi (Haninjin; the family of artemisia being that of Mugwort) is a herb that is used in part for medicinal effects but for some culinary purposes in Korea, and is in the preliminary stages of research for its benefits.

Currently, there is no human evidence but a few animal studies support that compounds in the water extracts may be potent as an anti-allergic medicine and that a 95% ethanolic extract may possess fat burning properties (via being a PPARδ activatior, a relatively unique mechanism for supplements)

What else is Haninjin known as?
Note that Haninjin is also known as:
  • Haninjin
  • Mugwort (refers To The Family Of Artemisia)
  • Artemisia Iwayomogi
Dosage information

There is insufficient evidence for a recommended dose for human consumption of Artemisia iwayomogi, although rat stdies have used 200 mg/kg of a 95% ethanolic extract for bioactivities. Assuming this dose, the estimated human doses are 32 mg/kg, or:

  • 2,200 mg for a 150 lb person
  • 2,900 mg for a 200 lb person
  • 3,600 mg for a 250 lb person

Optimal dosing times (once daily or multiple doses) or whether this herb needs to be taken with a meal or not is currently not known.

References
3.^Lee MY, Doh EJ, Park CH, Kim YH, Kim ES, Ko BS, Oh SEDevelopment of SCAR marker for discrimination of Artemisia princeps and A. argyi from other Artemisia herbsBiol Pharm Bull.(2006 Apr)
4.^Ding Y, Liang C, Yang SY, Ra JC, Choi EM, Kim JA, Kim YHPhenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cellsBiol Pharm Bull.(2010)
6.^Kim AR, Zou YN, Park TH, Shim KH, Kim MS, Kim ND, Kim JD, Bae SJ, Choi JS, Chung HYActive components from Artemisia iwayomogi displaying ONOO(-) scavenging activityPhytother Res.(2004 Jan)
7.^Chung EY, Byun YH, Shin EJ, Chung HS, Lee YH, Shin SAntibacterial effects of vulgarone B from Artemisia iwayomogi alone and in combination with oxacillinArch Pharm Res.(2009 Dec)
9.^Yu HH, Kim YH, Kil BS, Kim KJ, Jeong SI, You YOChemical composition and antibacterial activity of essential oil of Artemisia iwayomogiPlanta Med.(2003 Dec)
10.^Hwang JS, Ji HJ, Koo KA, Lee NH, Yeo HK, Cheong SW, Park JH, Oh GS, Yoon CS, Youn HJAIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of Fas geneBiol Pharm Bull.(2005 May)
11.^Lee JA, Sung HN, Jeon CH, Gill BC, Oh GS, Youn HJ, Park JHAIP1, a carbohydrate fraction from Artemisia iwayomogi, modulates the functional differentiation of bone marrow-derived dendritic cellsInt Immunopharmacol.(2008 Apr)
13.^Ahn H, Kim JY, Lee HJ, Kim YK, Ryu JHInhibitors of inducible nitric oxide synthase expression from Artemisia iwayomogiArch Pharm Res.(2003 Apr)
14.^Hwang JS, Chung HK, Bae EK, Lee AY, Ji HJ, Park DW, Jung HJ, Cho CW, Choi HJ, Lee DS, Lee KR, Youn HJThe polysaccharide fraction AIP1 from Artemisia iwayomogi suppresses apoptotic death of the mouse spleen cells in cultureArch Pharm Res.(2003 Apr)
17.^Kim SH, Choi CH, Kim SY, Eun JS, Shin TYAnti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy modelExp Biol Med (Maywood).(2005 Jan)
19.^Canbay A, Higuchi H, Bronk SF, Taniai M, Sebo TJ, Gores GJFas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosisGastroenterology.(2002 Oct)
20.^Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJDiet associated hepatic steatosis sensitizes to Fas mediated liver injury in miceJ Hepatol.(2003 Dec)
21.^Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman JRNA interference targeting Fas protects mice from fulminant hepatitisNat Med.(2003 Mar)
22.^Han JM, Kim HG, Choi MK, Lee JS, Park HJ, Wang JH, Lee JS, Son SW, Hwang SY, Son CGAqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligationFood Chem Toxicol.(2012 Oct)
23.^Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes MBenefit of farnesoid X receptor inhibition in obstructive cholestasisProc Natl Acad Sci U S A.(2006 Jul 25)
25.^Park EJ, Nan JX, Kim JY, Kang HC, Choi JH, Lee SJ, Lee BH, Kim SJ, Lee JH, Kim YC, Sohn DHThe ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in ratsJ Pharm Pharmacol.(2000 Jul)
26.^Sant'Anna LB, Cargnoni A, Ressel L, Vanosi G, Parolini OAmniotic membrane application reduces liver fibrosis in a bile duct ligation rat modelCell Transplant.(2011)